Feeding frequency affects glucose and lipid metabolism through SIRT1/AMPK pathway in growing pigs with the same amount of daily feed

2021 ◽  
pp. 108919
Author(s):  
He Zhang ◽  
Menglan Jia ◽  
Yong Su ◽  
Weiyun Zhu
Keyword(s):  
Lipid Metabolism ◽  
Growing Pigs ◽  
Feeding Frequency ◽  
Ampk Pathway ◽  
Glucose And Lipid Metabolism

scholarly journals GLP-1R activation is a key pathway to alleviate the metabolic disorder in L02 cells

2020 ◽  
Author(s):  
Qiao ji Tian ◽  
Yifeng Liu ◽  
Jia Liu ◽  
Peng Yuan ◽  
Haizhi Li ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Metabolic Disorder ◽  
Cell Model ◽  
Akt Pathway ◽  
Acid Oxidation ◽  
Ampk Pathway ◽  
Glucose And Lipid Metabolism ◽  
The Metabolic Syndrome ◽  
Hepatic Glucose ◽  
L02 Cells

Abstract Background Glucagon like peptide 1 (GLP-1) has been shown to regulate glucose and lipid metabolism in the liver by promoting insulin secretion. However, the direct regulation of GLP-1 on liver glucose and lipid metabolism was still controversial, due to the presence of GLP-1 receptors (GLP-1R) in human liver has not been determined. The aim of this study was to investigate the presence of GLP-1R in L02 cells (normal human hepatocytes), and to explore the direct effect of GLP-1, on hepatic glucose and lipid metabolism. Methods The insulin resistance (IR) cell model with metabolic disorder was constructed using FFAs (including oleic acid and fructose) to simulate the metabolic syndrome caused by high-fat and high-fructose in modern diet. Results The results showed that GLP-1R is expressed in L02 cells, and reduced in L02 with IR. The RNA interference experiment of GLP-1R suggested that GLP-1R activation decreased glycogenesis and increased intracellular glycogen content via AKT pathway independent of PI3K, and increased fatty acid oxidation and decreased lipid accumulation via AMPK pathway. Conclusions These results indicate that GLP-1 could directly regulate hepatic glucose and lipid metabolism by activating GLP-1R, which could be potential therapeutic targets. GLP-1R activation leads to reduction of gluconeogenesis and lipogenesis via PI3K-independent AKT pathway and AMPK pathway.

1060-P: The Effect of FGF21/GLP-1 Fusion Protein on Glucose and Lipid Metabolism Using Diabetic Mice Models

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1060-P
Author(s):  
LIXIN GUO ◽  
QI PAN ◽  
CHAO CHEN ◽  
SHUSHAN LIN ◽  
YU LI ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Fusion Protein ◽  
Diabetic Mice ◽  
Glucose And Lipid Metabolism

1878-P: The Role and Potential Mechanism of LncRNA Gm15441 in Skeletal Muscle Glucose and Lipid Metabolism

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1878-P
Author(s):  
LIANGHUI YOU ◽  
YU ZENG ◽  
NAN GU ◽  
CHENBO JI
Keyword(s):  
Skeletal Muscle ◽  
Lipid Metabolism ◽  
Potential Mechanism ◽  
Glucose And Lipid Metabolism

scholarly journals High-dose Glycerol Monolaurate Up-Regulated Beneficial Indigenous Microbiota without Inducing Metabolic Dysfunction and Systemic Inflammation: New Insights into Its Antimicrobial Potential

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1981 ◽  
Author(s):  
Qiufen Mo ◽  
Aikun Fu ◽  
Lingli Deng ◽  
Minjie Zhao ◽  
Yang Li ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Systemic Inflammation ◽  
Body Weight Gain ◽  
High Dose ◽  
Dependent Manner ◽  
Glucose And Lipid Metabolism ◽  
Glycerol Monolaurate ◽  
Indigenous Microbiota ◽  
Anti Inflammatory ◽  
Dose Dependent

Glycerol monolaurate (GML) has potent antimicrobial and anti-inflammatory activities. The present study aimed to assess the dose-dependent antimicrobial-effects of GML on the gut microbiota, glucose and lipid metabolism and inflammatory response in C57BL/6 mice. Mice were fed on diets supplemented with GML at dose of 400, 800 and 1600 mg kg−1 for 4 months, respectively. Results showed that supplementation of GML, regardless of the dosages, induced modest body weight gain without affecting epididymal/brown fat pad, lipid profiles and glycemic markers. A high dose of GML (1600 mg kg−1) showed positive impacts on the anti-inflammatory TGF-β1 and IL-22. GML modulated the indigenous microbiota in a dose-dependent manner. It was found that 400 and 800 mg kg−1 GML improved the richness of Barnesiella, whereas a high dosage of GML (1600 mg kg−1) significantly increased the relative abundances of Clostridium XIVa, Oscillibacter and Parasutterella. The present work indicated that GML could upregulate the favorable microbial taxa without inducing systemic inflammation and dysfunction of glucose and lipid metabolism.

scholarly journals Differences in the Effects of Anthocyanin Supplementation on Glucose and Lipid Metabolism According to the Structure of the Main Anthocyanin: A Meta-Analysis of Randomized Controlled Trials

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2003
Author(s):  
Risa Araki ◽  
Akira Yada ◽  
Hirotsugu Ueda ◽  
Kenichi Tominaga ◽  
Hiroko Isoda
Keyword(s):  
Lipid Metabolism ◽  
Meta Analysis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Resistance Index ◽  
Lipoprotein Cholesterol ◽  
Controlled Trials ◽  
Oh Groups ◽  
Chemical Structures ◽  
Glucose And Lipid Metabolism

The effectiveness of anthocyanins may differ according to their chemical structures; however, randomized clinical controlled trials (RCTs) or meta-analyses that examine the consequences of these structural differences have not been reported yet. In this meta-analysis, anthocyanins in test foods of 18 selected RCTs were categorized into three types: cyanidin-, delphinidin-, and malvidin-based. Delphinidin-based anthocyanins demonstrated significant effects on triglycerides (mean difference (MD): −0.24, p < 0.01), low-density lipoprotein cholesterol (LDL-C) (MD: −0.28, p < 0.001), and high-density lipoprotein cholesterol (HDL-C) (MD: 0.11, p < 0.01), whereas no significant effects were observed for cyanidin- and malvidin-based anthocyanins. Although non-significant, favorable effects on total cholesterol (TC) and HDL-C were observed for cyanidin- and malvidin-based anthocyanins, respectively (both p < 0.1). The ascending order of effectiveness on TC and LDL-C was delphinidin-, cyanidin-, and malvidin-based anthocyanins, and the differences among the three groups were significant (both p < 0.05). We could not confirm the significant effects of each main anthocyanin on glucose metabolism; however, insulin resistance index changed positively and negatively with cyanidin- and delphinidin-based anthocyanins, respectively. Therefore, foods containing mainly unmethylated anthocyanins, especially with large numbers of OH groups, may improve glucose and lipid metabolism more effectively than those containing methylated anthocyanins.

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