scholarly journals Ameliorative effect of the sea cucumber Holothuria arenicola extract against gastric ulcer in rats

2015 ◽  
Vol 72 ◽  
pp. 16-25 ◽  
Author(s):  
Sohair R. Fahmy ◽  
Mahmoud A. Amer ◽  
Mohannad H. Al-killidar
Keyword(s):  
Gastric Ulcer ◽  
Sea Cucumber ◽  
Ameliorative Effect ◽  
Holothuria Arenicola

scholarly journals Ameliorative effect of Albizzia procera leaves extract against experimentally induced gastric ulcer models in Wistar albino rats

2021 ◽  
Vol 13 (1) ◽  
pp. 308-315
Author(s):  
Vivek Srivastava ◽  
Santosh Kumar Verma ◽  
Neha Mathur ◽  
Kapil Kumar Goel
Keyword(s):  
Gastric Ulcer ◽  
Ethanolic Extract ◽  
Gastric Fluid ◽  
Gastric Ulcers ◽  
Albino Rats ◽  
Traditional Medicines ◽  
Pylorus Ligation ◽  
Ameliorative Effect ◽  
Wistar Albino Rats ◽  
Experimentally Induced

Albizzia procera belongs to family Fabaceae and has several phytoconstituents like flavonoids, terpenes, alkaloids, saponins etc. The plant is commonly used in traditional medicines. The objective of the present study was to assess the ameliorative effect of A. procera leaves extract against an experimentally induced gastric ulcer in albino rats. The antiulcer, antisecretory and cytoprotective properties of an ethanolic extract prepared from the leaves was evaluated. When given in a 200 mg/kg oral (per. os) dose, the extract produced 74% and 85% protection index in ethanol-induced ulcer model and pylorus ligation model, respectively.  Additionally, the extract also prohibited the formation of haemorrhage and edema, significantly lessened catalase activity (p<0.0001) and the lipid peroxidation level (p<0.0001) in the glandular tissue of Wistar albino rats. Furthermore, the extract also significantly diminished the total acidity(p<0.0001) of the gastric fluid by increasing its pH (p<0.0001). The occupancy of different phytoconstituents in the extract, such as flavonoids and tannins were identified that may be responsible for its gastro-protective activity. All these results provide a basis explaining the antiulcer ability of A. procera being useful in the management of gastric ulcers.

The Effects of Sea Cucumber as an Anti-gastritis, Anti-gastric Ulcer, and Anti-Helicobater

2012 ◽  
Vol 41 (5) ◽  
pp. 605-611 ◽  
Author(s):  
Hong-Geun Oh ◽  
Dae-In Moon ◽  
Jung-Hoon Kim ◽  
Young-Rye Kang ◽  
Jung-Woo Park ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Sea Cucumber

scholarly journals Formulation and Evaluation of the sea cucumber, Holothuria arenicola extract incorporated skin cream

2020 ◽  
Vol 13 (2) ◽  
pp. 232-239
Author(s):  
Ayman Saber Mohamed ◽  
Sohair Ramadan Fahmy ◽  
Abdelaziz A. Elsayed
Keyword(s):  
Sea Cucumber ◽  
Radical Scavenging Activity ◽  
Liquid Paraffin ◽  
Radical Scavenging ◽  
Scavenging Activity ◽  
Water Emulsion ◽  
Oil In Water ◽  
Oil In Water Emulsion ◽  
Holothuria Arenicola ◽  
Stability Results

Background: Cucumber extract is often used for skin problems, wrinkles, sunburn, and as an antioxidant. Thereby, the main objective of the present investigation was to develop a topical skincare cream (w/o) loaded with the sea cucumber, Holothuria arenicola extract (HaE). Methods: Oil in water emulsion-based cream was prepared by incorporating liquid paraffin, soft wax, cetostearyl alcohol in the oil phase, and borax in the water phase respectively with 1 gm of HaE. The evaluation of HaE cream was done on different parameters like ph, viscosity, spreadability, extrudability, irritancy and stability. Results: HaE showed good appearance, homogeneity, spreadability, diffusion, consistency, pH, extrudability, and spreadability without any irritancy to skin. The present results showed that HaE cream has radical scavenging activity in range from 57 to 70 % and NO scavenging activity in range from 25 to 49 %. Conclusion: The formulated HaE cream was successfully developed that met the relevant pharmaceutical characteristics form. The developed HaE cream could be added in topical formulations in order to protect skin against damage caused by free radicals due to its antioxidant activity.

Ameliorative effect of Boesenbergin A, a chalcone isolated from Boesenbergia rotunda (Fingerroot) on oxidative stress and inflammation in ethanol-induced gastric ulcer in vivo

2020 ◽  
Vol 261 ◽  
pp. 113104 ◽  
Author(s):  
Syam Mohan ◽  
Yahya Hasan Hobani ◽  
Emad Shaheen ◽  
Alaa Sayed Abou-Elhamd ◽  
Aymen abdelhaleem ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gastric Ulcer ◽  
Ameliorative Effect ◽  
Boesenbergia Rotunda
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