Comparison of Serum Dkk1 (Dickkopf-1) and Bone Mineral Density in Patients on Bisphosphonate Treatment Vs no Treatment

2013 ◽  
Vol 16 (1) ◽  
pp. 118-124 ◽  
Author(s):  
Adeel R. Memon ◽  
Joseph S. Butler ◽  
Michael V. O'Riordan ◽  
Elizabeth Guerin ◽  
Borislav D. Dimitrov ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Bisphosphonate Treatment ◽  
Mineral Density ◽  
Dickkopf 1

Comparative effects of denosumab or bisphosphonate treatment on bone mineral density and calcium metabolism in postmenopausal women

Maturitas ◽  
2017 ◽  
Vol 100 ◽  
pp. 156
Author(s):  
Evaggelia Karopoulou ◽  
Areti Augoulea ◽  
Ioannis Triantafyllopoulos ◽  
Demetrios Rizos ◽  
Eleni Armeni ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Calcium Metabolism ◽  
Bisphosphonate Treatment ◽  
Mineral Density

Bisphosphonate treatment in the bone disorders in children: a systematic review

MedAlliance ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 59-70
Keyword(s):  
Bone Mineral Density ◽  
Systematic Review ◽  
Adverse Event ◽  
Bone Mineral ◽  
Bone Pain ◽  
Dose Effect ◽  
Age Group ◽  
Bisphosphonate Treatment ◽  
Mineral Density

Summary Background: bisphosphonates use over three decades in a variety conditions in children. However, the evi-dence of its use is limited. Aims:systematic analysis of publications regarding the effectiveness and safety of bisphosphonates (BPs) in children. Methods. PubMed and eLIBRARY were searched for eligible articles of Rus-sian and foreign authors up to February 2021. According the PRISMA strategies, 35 studies (data of 2545 patients) were included into the analysis. Results. More than 80% patients suffered from nonbacterial osteomyelitis (NBO) and osteogenesis imperfecta (OI). BPs in children are effective for increasing the bone mineral density for decreased fracture incidence, to reduce bone pain, to re-lieve inflammation and to improve the quality of patients’ life. The most frequently adverse event was the first-dose effect, such as flu-like syndrome. In the age group under study, no severe adverse events characteristic of adults have been seen (mandibular necrosis). Conclusions. BPs are efficient and safe in children with OI, NBO and cere-bral palsy in order to restore the bone mineral density. Further research is required to strengthen the recom-mendations made, while the wider use of BPs require revision of current registration documents in accordance with global guidelines.

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