Minimal Clinically Important Difference of the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF) for Fatigue Worsening in Asian Breast Cancer Patients

6589 Background: Establishing the Minimal Clinically Important Difference (MCID) is essential for interpreting the clinical relevance of patient reported outcomes. This is the first study to date to determine the MCID of FACT-Cog, a 37-item validated subjective neuropsychological instrument designed to evaluate cancer patients’ perceived cognitive deterioration on their quality of life. Methods: This prospective, observational study involved 220 breast cancer patients who have completed FACT-Cog and EORTC-QLQ-C30 at two time points: baseline and at least 3 months following chemotherapy. The MCID was computed using 3 approaches: 1) an anchor-based approach utilized the validated EORTC-QLQ-C30-Cognitive Functioning scale (CF) as the anchor for patients who showed a minimal deterioration on the CF (defined as a one-step deterioration on the CF scale); 2) a Receiver Operating Characteristic (ROC) curve was used to identify an optimal MCID cut-off point for deterioration; 3) a distribution-based approach utilized the 0.33 SD, 0.5 SD and one standard error of measurement (SEM) of the total FACT-Cog score (148 points) to estimate the MCID. Results: There was moderate correlation between the mean change scores of FACT-Cog and CF (rp= 0.43, p<0.001). The CF-anchored MCID was 9.6 points (95% CI 4.4 - 14.8). MCID derived from the ROC method was 7.5 points (AUC: 0.75; sensitivity: 75.6%; specificity: 68.8%). Using the distribution-based approach, MCID corresponding to effect sizes of 0.33SD to 0.5SD of the total FACT-Cog score ranged from 6.9 – 10.3 points and one-SEM criterion resulted in a MCID estimate of 10.6 points. Combining results from all approaches, the MCID identified for FACT-Cog ranged from 6.9 – 10.6 points (4.7% to 7.2% of total score). Conclusions: A 6.9 to 10.6 points reduction of the FACT-Cog score corresponds to the smallest clinically-relevant perceived cognitive deterioration. These estimates are important as they can facilitate the interpretation of patient-reported cognitive changes and sample size estimation in future studies.

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Minimal clinically important difference (MCID) for the functional assessment of cancer therapy: Cognitive function (FACT-Cog) in breast cancer patients

Journal of Clinical Epidemiology ◽

10.1016/j.jclinepi.2013.12.011 ◽

2014 ◽

Vol 67 (7) ◽

pp. 811-820 ◽

Cited By ~ 46

Author(s):

Yin Ting Cheung ◽

Yu Lee Foo ◽

Maung Shwe ◽

Yee Pin Tan ◽

Gilbert Fan ◽

...

Keyword(s):

Breast Cancer ◽

Cognitive Function ◽

Cancer Therapy ◽

Cancer Patients ◽

Functional Assessment ◽

Minimal Clinically Important Difference ◽

Breast Cancer Patients ◽

Clinically Important Difference

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Diet quality and its relationship with overweight and laboratory parameters in breast cancer patients undergoing treatment

10.21203/rs.2.11380/v2 ◽

2019 ◽

Author(s):

Krystal Ng LS ◽

Chan Yoke Mun ◽

Zalilah MS

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Fatty Acids ◽

Serum Albumin ◽

Cancer Patients ◽

Diet Quality ◽

Short Form ◽

Healthy Eating Index ◽

Breast Cancer Patients ◽

Laboratory Parameters

Abstract Background Overweight is the common issue existed among breast cancer patients, leading to poor cancer prognosis and survival. However, previous studies have focused merely on single nutrients or food groups. This study aimed to determine whether diet quality was associated with overweight and laboratory parameters among breast cancer patients undergoing treatment.Methods A cross sectional study comprises of 163 patients was conducted from January to May 2017. Diet quality and level of physical activity of patients were ascertained using Healthy Eating Index (HEI)-2015 and International Physical Activity Questionnaire (IPAQ)-short form, respectively. Data were available on body mass index and biochemical data, including of serum albumin, serum hemoblogbin and neutrophils count. Logistic regression was performed to identify the association between diet quality and overweight, serum albumin, serum hemoglobin and neutrophils count.Results The mean total HEI score (standard deviation) of the breast cancer patients was 63.86 (8.75). More than 80% of the subjects did not adhere to the dietary guidelines for whole grains, dairy, refined grains, ratio of poly- and mono-unsaturated fatty acids to saturated fatty acids components. In the multivariate model, those who perceived higher score of total HEI-2015 were less likely to experience overweight (Q4 vs Q1: OR=0.36; 95% CI=0.13, 0.99) while reported higher concentration of serum hemoglobin (Q4 vs Q1: OR=0.36; 95% CI=0.13, 0.98; Q3 vs Q1: OR=0.35; 95% CI=0.13, 0.92). Non-significant associations of diet quality were shown for serum albumin and neutrophils count.Conclusions A majority of breast cancer patients require dietary modification, especially for fatty acids, grains and dairy products. Diet quality may associate with overweight. A balanced diet that address the problem of overweight may help to maintain a good nutritional status and to improve cancer care in breast cancer patients during treatment. Future prospective studies are required to confirm this association.

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Diet quality and its relationship with overweight and laboratory parameters in breast cancer patients undergoing treatment

10.21203/rs.2.11380/v3 ◽

2019 ◽

Author(s):

Krystal Ng LS ◽

Chan Yoke Mun ◽

Zalilah MS

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Fatty Acids ◽

Serum Albumin ◽

Cancer Patients ◽

Diet Quality ◽

Short Form ◽

Healthy Eating Index ◽

Breast Cancer Patients ◽

Laboratory Parameters

Abstract Background Overweight is the common issue existed among breast cancer patients, leading to poor cancer prognosis and survival. However, previous studies have focused merely on single nutrients or food groups. This study aimed to determine whether diet quality was associated with overweight and laboratory parameters among breast cancer patients undergoing treatment.Methods A cross sectional study comprises of 163 patients was conducted from January to May 2017. Diet quality and level of physical activity of patients were ascertained using Healthy Eating Index (HEI)-2015 and International Physical Activity Questionnaire (IPAQ)-short form, respectively. Data were available on body mass index and biochemical data, including of serum albumin, serum hemoblogbin and neutrophils count. Logistic regression was performed to identify the association between diet quality and overweight, serum albumin, serum hemoglobin and neutrophils count.Results The mean total HEI score (standard deviation) of the breast cancer patients was 63.86 (8.75). More than 80% of the subjects did not adhere to the dietary guidelines for whole grains, dairy, refined grains, ratio of poly- and mono-unsaturated fatty acids to saturated fatty acids components. In the multivariate model, those who perceived higher score of total HEI-2015 were less likely to experience overweight (Q4 vs Q1: OR=0.36; 95% CI=0.13, 0.99) while reported higher concentration of serum hemoglobin (Q4 vs Q1: OR=0.36; 95% CI=0.13, 0.98; Q3 vs Q1: OR=0.35; 95% CI=0.13, 0.92). Non-significant associations of diet quality were shown for serum albumin and neutrophils count.Conclusions A majority of breast cancer patients require dietary modification, especially for fatty acids, grains and dairy products. Diet quality may associate with overweight. A balanced diet that address the problem of overweight may help to maintain a good nutritional status and to improve cancer care in breast cancer patients during treatment. Future prospective studies are required to confirm this association.

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Illness uncertainty in breast cancer patients: Validation of the 5-item short form of the Mishel Uncertainty in Illness Scale

European Journal of Oncology Nursing ◽

10.1016/j.ejon.2014.10.009 ◽

2015 ◽

Vol 19 (2) ◽

pp. 113-119 ◽

Cited By ~ 19

Author(s):

Kari Britt Hagen ◽

Turid Aas ◽

Kirsten Lode ◽

Jennifer Gjerde ◽

Ernst Lien ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Short Form ◽

Breast Cancer Patients ◽

Illness Uncertainty ◽

Uncertainty In Illness

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Nutritional Status and Quality of Life in Breast Cancer Patients in Karawaci General Hospital

Indonesian Journal of Cancer ◽

10.33371/ijoc.v10i1.413 ◽

2016 ◽

Vol 10 (1) ◽

pp. 1

Author(s):

ANDREE KURNIAWAN ◽

NATA PRATAMA HARDJO LUGITO

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Nutritional Status ◽

Cancer Patients ◽

Physical Functioning ◽

Short Form ◽

Subjective Global Assessment ◽

Breast Cancer Patients ◽

Sf 36

ABSTRACTCancer is related to a deterioration of nutritional status and quality of life (Qol), but the extent of these conditions in patients with breast cancer has not been studied well. Malnutrition is prevalent among cancer patients and maybe correlated with altered quality of life. The aim of this study is to evaluate the association of QoL and nutritional status after breast cancer diagnosed. Nutritional status was evaluated with Patient Generated Subjective Global Assessment and QoL using Short form 36 (SF-36) and also with the specific module for breast cancer patients. A consecutive sampleof twenty two patients diagnosed with breast cancer was evaluated. The associations of QoL with stadium and nutrition status were evaluated using T-test analysis. The mean of body mass index was 21.3 kg/m2. Fifty percent patient have menopause. Most patients were stage II (77.3%), the others stage III (18.2%) and stage I (4.5%). Sixty eight point two percent had risk of malnutrition. The stadium of tumor was significantly related to physical functioning (p < 0.000), physical limitation (p < 0.024), emotional limitation (p < 0.013), well-being (p < 0.020), health changes (p < 0.010). Thestatus of nutrition was significantly related to physical functioning (p < 0.001), loss of energy (p < 0.010) and general health (p <0.005). For Conclusion, the status of nutrition breast cancer patients were related to QoL especially physical functioning, loss of energy and general health after they were diagnosed.ABSTRAKKanker sangat terkait dengan perburukan status nutrisi dan kualitas hidup. Namun demikian, belum banyak studi yang yang melaporkan masalah nutrisi dan kulitas hidup pada kanker payudara. Malnutrisi sering ditemukan pada kanker dan mungkin terkait dengan perubahan kulaitas hidup. Tujuan penelitian ini adalah untuk mengevaluasi hubungan antara kualitas hidup dengan status nutrisi setelah kanker payudara terdiagnosis. Evaluasi status nutrisi dilakukan dengan Patient Generated Subjective Global Assessment dan kualitas hidup dengan Short form 36 (SF-36) sertakarakteristik pada kanker payudara. Sampel diambil dengan teknik konsekutif terhadap 22 pasien yang terdiagnosis kanker payudara. Hubungan kualitas hidup dengan stadium kanker dan status nutrisi dinilai menggunakan analisis T-test. Indeks massa tubuh rata-rata adalah 21,3 kg/m2. Lima puluh pasien telah menopause. Terbanyak adalah stadium 2 (77,3%), stadium 3 (18,2%), dan stadium 1 (4,5%). Enam puluh dua koma dua persen berisiko malnutrisi. Stadium tumor secara bermakna berhubungan dengan fungsi fisik (p <0,000), keterbatasan fisik (p<0,024), keterbatasan emosi(p<0,013), rasa nyaman (p<0,020), dan perubahan kesehatan (p<0,000). Status nutrisi berhubungan secara bermakna dengan fungsi fisik (p<0,001), kehilangan energi (p<0,010), dan kesehatan secara umum (p<0,005). Simpulan, status nutrisi pasien kanker payudara berhubungan dengan kualitas hidup, terutama fungsi fisik, kehilangan energi, status kesehatan umum setelah mereka terdiagnosis.

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Profiles of instrumental, emotional, and informational support in Chinese breast cancer patients undergoing chemotherapy: a latent class analysis

BMC Women s Health ◽

10.1186/s12905-021-01307-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Tingting Cai ◽

Qingmei Huang ◽

Changrong Yuan

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Social Relationships ◽

Short Form ◽

Educational Background ◽

Anxiety And Depression ◽

Depression Symptoms ◽

Informational Support ◽

Breast Cancer Patients ◽

Form Analysis

Abstract Background To date, few studies have assessed social relationships in patients with breast cancer during their chemotherapy process. This study aimed to explore profiles of instrumental, emotional, and informational support in Chinese breast cancer patients undergoing chemotherapy. Methods In a cross-sectional study performed between September 2018 and September 2020 in China, 638 patients with breast cancer completed demographic information questionnaires, the PROMIS-Social Relationships Short Forms, the PROMIS-Anxiety Short Form, and the PROMIS-Depression Short Form. Analysis of variance and chi-square tests were performed to examine between-group differences in demographic characteristics, anxiety, and depression outcomes across the identified latent classes. Multinomial logistic regression was performed to identify the correlation of significant variables among the identified classes. Results Three profiles of social relationships were identified: Class 1-low social relationships group (14.3%), Class 2-high instrumental support, medium emotional and informational support group (24.6%), and Class 3-high social relationships group (61.1%). The findings revealed the heterogeneity of instrumental, emotional, and informational support in Chinese breast cancer patients undergoing chemotherapy, which was significantly correlated with educational background, monthly family income, health insurance, and employment status. Additionally, patients with low instrumental, emotional, and informational support were more likely to report high levels of anxiety and depression. Conclusions When conducting interventions to promote social relationships during the chemotherapy process, healthcare providers should consider the sociodemographic characteristics, anxiety levels, and depression symptoms of patients with breast cancer and identify high-risk patients for tailored interventions.

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Metastatic breast cancer: do current treatments improve quality of life? A prospective study

Sao Paulo Medical Journal ◽

10.1590/s1516-31802006000400006 ◽

2006 ◽

Vol 124 (4) ◽

pp. 203-207 ◽

Cited By ~ 2

Author(s):

Fernanda Amado ◽

Maria Teresa Cruz Lourenço ◽

Daniel Deheinzelin

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Metastatic Breast Cancer ◽

Cancer Patients ◽

Short Form ◽

Performance Status ◽

Metastatic Breast ◽

Breast Cancer Patients ◽

Sf 36

CONTEXT AND OBJECTIVE: In metastatic breast cancer cases, the currently available therapeutic approaches provide minimal improvement in survival. As such, quality of life (QOL) becomes one of the main objectives of treatment. It is not known whether current treatments derived from trials improve QOL. The aim was to evaluate changes in QOL among metastatic breast cancer patients receiving treatment derived from trials. DESIGN AND SETTING: Prospective observational QOL survey in a tertiary cancer center. METHODS: To evaluate the influence of current treatments on patients' QOL, the Medical Outcomes Study Short Form-36 (SF-36) and the Beck Depression Inventory (BDI) were applied on three occasions: before starting treatment and at the 6th and 12th weeks, to consecutive metastatic breast cancer patients over a one-year period. RESULTS: We found an improvement in QOL in the sample evaluated (n = 40), expressed by changes in the overall SF-36 score (p = 0.002) and the BDI (p = 0.004). Taken individually, the SF-36 components Pain, Social Functioning and Mental Health also improved significantly. Patients with worse initial performance status and secondary symptoms displayed greater improvement than those with better initial performance status and asymptomatic disease (p < 0.001). Patients who received more than one type of therapy showed larger gains than those given only one type (p = 0.038). CONCLUSIONS: In our environment, current metastatic breast cancer treatments can improve QOL, especially among symptomatic patients and those with low performance status.

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Breast pain in a diverse population of breast cancer patients

10.21203/rs.3.rs-36629/v1 ◽

2020 ◽

Author(s):

Jami Fukui ◽

Erin Bantum ◽

Madison Meister ◽

Shannon Lim ◽

Ashley Davidson Marumoto ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Ethnic Differences ◽

Short Form ◽

Mcgill Pain Questionnaire ◽

Diverse Population ◽

Breast Pain ◽

Breast Cancer Patients ◽

Early Stage Disease ◽

Racial Ethnic

Abstract Background Breast cancer is the most common cancer in women. The majority of women with breast cancer present with early stage disease requiring surgical management. Post-operative breast pain has been reported to be anywhere from 25–60%. Racial disparities in cancer treatment-related symptom burden are known and linked to worse treatment outcomes. There is sparse data regarding racial/ethnic differences in breast pain among breast cancer patients. We evaluated the prevalence of breast pain in breast cancer patients and characterized the pain using a modified short-form McGill pain questionnaire in our diverse population. Methods We performed a cross sectional study, including 237 patients from various outpatient oncology clinics and breast cancer survivorship groups on Oahu and Maui. Participants had the option to complete the survey in person at the clinic or online. Results Eight-four respondents (35.4%) reported breast pain. There were no statistical differences seen in breast pain likelihood according to racial/ethnic group. On multivariate analysis, we did however find significant racial/ethnic differences in the amount of breast pain, where Chinese, Native Hawaiian and Mixed Asian participants reported significantly less pain compared to White participants (1.36, 2.16 and 2.22 vs 2.92, p = < 0.0001, 0.03 and 0.05) on a 10-point pain scale. We found differences in breast pain according to age, chemotherapy, radiation therapy and endocrine therapy use as well as survey location. No differences were seen according to the type of breast or axillary surgery. The most common descriptors of breast pain were sensory compared to affective characteristics. The average self-reported pain score found was 3/10. Overall, in women with breast pain, 33.4% reported the breast pain affected their sleep with 16.7% reporting it affected their work and 15.4% reporting it affected their sexual activity. Conclusions Breast pain is a significant problem in our breast cancer community. This survey assessment has informed our understanding of breast pain in our diverse population. In turn we are developing culturally appropriate pain management strategies to treat this challenging symptom common in breast cancer survivors.

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Validation and Clinical Application of the Chinese Version of the M. D. Anderson Symptom Inventory(MDASI-C) in Breast Cancer Patients

10.21203/rs.3.rs-577518/v1 ◽

2021 ◽

Author(s):

Renwang Chen ◽

Qiong Wang ◽

Ting Hu ◽

Jue Wang ◽

Yu-xiu Xie ◽

...

Keyword(s):

Breast Cancer ◽

Construct Validity ◽

Cancer Patients ◽

Assessment Tool ◽

Reliability And Validity ◽

Treatment Phase ◽

Chinese Version ◽

Breast Cancer Patients ◽

Good Reliability ◽

Symptom Inventory

Abstract Purpose To validate and use the Chinese Version of the M. D. Anderson Symptom Inventory (MDASI-C) to assess the symptom burden of breast cancer patients of China. And to reveal the features of the symptoms and provide a basis for improving their quality of life.Methods A total of 342 breast cancer patients participated in the study. All patients had pathological diagnosis. They were investigated and evaluated from November 2020 to February 2021 with MDASI-C. The reliability and validity were evaluated respectively. Cluster analysis and correlation analysis were carried out.Results The Cronbach’s alpha coefficient of the symptom and interference items was 0.827 and 0.880, respectively, which meant good reliability. Construct validity revealed a four-factor structure. The Kaiser- Meyer-Olkin (KMO) value was 0.760, which meant good construct validity. The patient's KPS, treatment phase and cancer stage were grouped, and the differences of scores within the groups were significant. The patient's employment status, education level and age had a significant correlation with symptoms. The top three symptoms were disturbed sleep (3.10 ± 2.52), diffificulty remembering (2.54 ± 2.30) and fatigue (2.24 ± 2.13). The higher the patient's education, the lower their symptoms. Patients' Body Mass Index (BMI), hemoglobin (Hb), alkaline phosphatase (ALP), neutral granulocyte lymphocyte ratio (N/L), and serum albumin globulin ratio (A/G) also had an effect on some of the symptoms of patients. Conclusions MDASI-C is a reliable and effective assessment tool when evaluating patients with breast cancer of China. The symptoms were related to many clinical, biochemical indicators.

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