Simultaneous determination of Maillard reaction impurities in memantine tablets using HPLC with charged aerosol detector

2011 ◽  
Vol 56 (5) ◽  
pp. 887-894 ◽  
Author(s):  
Lidia Rystov ◽  
Richard Chadwick ◽  
Kevin Krock ◽  
Tao Wang
Keyword(s):  
Simultaneous Determination ◽  
Maillard Reaction ◽  
Charged Aerosol ◽  
Charged Aerosol Detector

scholarly journals Development and Validation of a Chromatography Method Using Tandem UV/Charged Aerosol Detector for Simultaneous Determination of Amlodipine Besylate and Olmesartan Medoxomil: Application to Drug-Excipient Compatibility Study

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Ariadne M. Brondi ◽  
Jerusa S. Garcia ◽  
Marcello G. Trevisan
Keyword(s):  
Simultaneous Determination ◽  
Olmesartan Medoxomil ◽  
Ternary Mixtures ◽  
Array Detector ◽  
Compatibility Study ◽  
Amlodipine Besylate ◽  
Charged Aerosol ◽  
Charged Aerosol Detector ◽  
Relative Standard

A study was carried out to investigate compatibility of amlodipine besylate and olmesartan medoxomil with a variety of pharmaceutical excipients. Both drugs are antihypertensive agents that can be administered alone, in monotherapy, or in pharmaceutical association. The studies were performed using binary and ternary mixtures, and samples were stored for 3 and 6 months at 40°C under 75% relative humidity and dry conditions. For this study, a method based on high-performance liquid chromatography (HPLC) was developed and validated for the simultaneous determination of amlodipine besylate and olmesartan medoxomil in samples from pharmaceutical preformulation studies using diode array detector (DAD) and charged aerosol detector (CAD). The runtime per sample was 10 min with retention time of 7.926 min and 4.408 min for amlodipine and olmesartan, respectively. The validation was performed according to ICH guidelines. The calibration curve presents linear dynamic range from 12 to 250 μg mL−1 for amlodipine and from 25 to 500 μg mL−1 for olmesartan with coefficient of determination (R2 ≥ 0.9908) while repeatability and reproducibility (expressed as relative standard deviation) were lower than 1.0%. The excipients such as corn starch, croscarmellose sodium, magnesium stearate, polyvinyl alcohol, talc, polyvinylpyrrolidone, lactose monohydrate, and polyethylene glycol showed potential incompatibilities after accelerated stability testing.

scholarly journals Determination of Impurities in 17β-Estradiol Reagent by HPLC with Charged Aerosol Detector

2010 ◽  
Vol 59 (3) ◽  
pp. 219-224 ◽  
Author(s):  
Taichi Yamazaki ◽  
Toshihide Ihara ◽  
Satoe Nakamura ◽  
Kenji Kato
Keyword(s):  
Charged Aerosol ◽  
Charged Aerosol Detector ◽  
17Β Estradiol ◽  
Determination Of Impurities

DETERMINATION OF CHLORHEXIDINE DIGLUCONATE IN DISINFECTANTS

2018 ◽  
Vol 61 (8) ◽  
pp. 4
Author(s):  
Sergey V. Andreev ◽  
Evgeny S. Belyaev ◽  
Anna O. Ivanova ◽  
Elvina A. Novikova ◽  
Anatoly A. Ishchenko
Keyword(s):  
Bromophenol Blue ◽  
Array Detector ◽  
Diode Array ◽  
Blue Color ◽  
Chlorhexidine Digluconate ◽  
Diode Array Detector ◽  
Charged Aerosol ◽  
Charged Aerosol Detector ◽  
Wide Range

Chlorhexidine digluconate has been widely used in lenticular compositions, skin antiseptics and other ready-to-use disinfectants. This is due to its low toxicity, as well as a wide range of antimicrobial effects. A commonly used method for the analysis of commercially available chlorhexidine digluconate (usually available as a 20% aqueous solution) is high-performance liquid chromatography. In this article, the main methods of analysis used to determine chlorhexidine digluconate in disinfectants and skin antiseptics are considered. A new simple technique for the determination of chlorhexidine digluconate in technical products and disinfectants based on acid-base titration in alcohol-ketone is developed. It is shown that in this medium hydrochloric acid interacts with two nitrogen atoms of the chlorhexidine digluconate molecule. The end point of the titration is established by the transition of the blue color to green in the presence of bromophenol blue. The range of measured concentrations is from 0.1 to 2.0 mass%. The relative error of the method is 2.5% with the confidence probability P = 0.95. A comparison of the diode array detector and the charged aerosol detector for the determination of chlorhexidine digluconate has been performed. It is shown that a charged aerosol detector can be used to analyze chlorhexidine digluconate in cases where it is difficult to analyze with an ultraviolet or diode array detector. However, the sensitivity of the detector of charged aerosols is significantly lower than that of the diode matrix, and the linearity range is smaller. All methods were tested on model samples, as well as on samples of disinfectants, skin antiseptics, soaps and wipes with antibacterial effect.

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