scholarly journals Simultaneous quantification of seven repurposed COVID-19 drugs remdesivir (plus metabolite GS-441524), chloroquine, hydroxychloroquine, lopinavir, ritonavir, favipiravir and azithromycin by a two-dimensional isotope dilution LC–MS/MS method in human serum

2021 ◽  
Vol 196 ◽  
pp. 113935
Author(s):  
Katharina Habler ◽  
Mathias Brügel ◽  
Daniel Teupser ◽  
Uwe Liebchen ◽  
Christina Scharf ◽  
...  
Keyword(s):  
Human Serum ◽  
Isotope Dilution ◽  
Two Dimensional ◽  
Simultaneous Quantification

Simultaneous quantification of proteins in human serum via sulfur and iron using HPLC coupled to post-column isotope dilution mass spectrometry

2014 ◽  
Vol 6 (19) ◽  
pp. 7655-7662 ◽  
Author(s):  
Liuxing Feng ◽  
Dan Zhang ◽  
Jun Wang ◽  
Hongmei Li
Keyword(s):  
Mass Spectrometry ◽  
Human Serum ◽  
Isotope Dilution ◽  
Isotope Dilution Mass Spectrometry ◽  
Quantification Method ◽  
Simultaneous Quantification ◽  
Icp Ms

A new simultaneous quantification method for Tf and Alb in human serumviasulfur and iron using HPLC-ID-ICP-MS.

The Carriers of Native Vitamin B12 in Normal Human Serum

1977 ◽  
Vol 53 (5) ◽  
pp. 453-457 ◽  
Author(s):  
C. A. Hall
Keyword(s):  
Vitamin B12 ◽  
Human Serum ◽  
Isotope Dilution ◽  
Serum Vitamin ◽  
Total Serum ◽  
Plasma Vitamin ◽  
Isotope Dilution Assay ◽  
Dilution Assay ◽  
Normal Human ◽  
Transcobalamin Ii

1. After fractionation of the vitamin B12-binding proteins of ten normal sera the components containing transcobalamin II and R-type binders of vitamin B12 respectively were studied for endogenous vitamin B12 content by two distinct systems of vitamin B12 assay. 2. The measurements of total serum vitamin B12 by either bioassay with Euglena gracilis or a radioisotope dilution assay agreed closely. 3. The native vitamin B12 carried by transcobalamin II was higher as measured by bioassay than by isotope dilution assay. 4. The presence of the transcobalamin II fraction of human serum altered the key reaction between the binding reagent of the isotope dilution assay, so that this assay failed to measure vitamin B12 quantitatively. 5. Probably, the mean fraction of plasma vitamin B12 carried by transcobalamin II is in the range 20–30%.

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