Younger gestational age is associated with increased risk of adverse neurodevelopmental outcome during infancy in congenital diaphragmatic hernia

2016 ◽  
Vol 51 (7) ◽  
pp. 1084-1090 ◽  
Author(s):  
Enrico Danzer ◽  
Marsha Gerdes ◽  
Jo Ann D'Agostino ◽  
Judy Bernbaum ◽  
Casey Hoffman ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Gestational Age ◽  
Neurodevelopmental Outcome ◽  
Increased Risk

scholarly journals Optimal gestational age at delivery for congenital diaphragmatic hernia

2020 ◽  
Author(s):  
H. Bouchghoul ◽  
G. Dumery ◽  
F. M. Russo ◽  
A. G. Cordier ◽  
N. Le Sache ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Gestational Age ◽  
Gestational Age At Delivery

scholarly journals Prioritization of Candidate Genes for Congenital Diaphragmatic Hernia in a Critical Region on Chromosome 4p16 using a Machine-Learning Algorithm

2018 ◽  
Vol 07 (04) ◽  
pp. 164-173 ◽  
Author(s):  
Ian Campbell ◽  
Samantha Stover ◽  
Andres Hernandez-Garcia ◽  
Shalini Jhangiani ◽  
Jaya Punetha ◽  
...  
Keyword(s):  
Machine Learning ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Critical Region ◽  
Large Scale ◽  
Learning Algorithm ◽  
Heart Defects ◽  
Machine Learning Algorithm ◽  
Increased Risk ◽  
Chromosome 4P16

AbstractWolf–Hirschhorn syndrome (WHS) is caused by partial deletion of the short arm of chromosome 4 and is characterized by dysmorphic facies, congenital heart defects, intellectual/developmental disability, and increased risk for congenital diaphragmatic hernia (CDH). In this report, we describe a stillborn girl with WHS and a large CDH. A literature review revealed 15 cases of WHS with CDH, which overlap a 2.3-Mb CDH critical region. We applied a machine-learning algorithm that integrates large-scale genomic knowledge to genes within the 4p16.3 CDH critical region and identified FGFRL1, CTBP1, NSD2, FGFR3, CPLX1, MAEA, CTBP1-AS2, and ZNF141 as genes whose haploinsufficiency may contribute to the development of CDH.

scholarly journals Impact of preterm birth on parental separation: a French population-based longitudinal study

BMJ Open ◽  
2017 ◽  
Vol 7 (11) ◽  
pp. e017845 ◽  
Author(s):  
Simon Nusinovici ◽  
Bertrand Olliac ◽  
Cyril Flamant ◽  
Jean-Baptiste Müller ◽  
Marion Olivier ◽  
...  
Keyword(s):  
Gestational Age ◽  
Neurodevelopmental Outcome ◽  
Population Based ◽  
Parental Separation ◽  
Socioeconomic Conditions ◽  
Low Socioeconomic ◽  
Increased Risk ◽  
Living Together ◽  
Maternity Clinics

ObjectiveThe objective of this study was to investigate both the effects of low gestational age and infant’s neurodevelopmental outcome at 2 years of age on the risk of parental separation within 7 years of giving birth.DesignProspective.Setting24 maternity clinics in the Pays-de-la-Loire region.ParticipantsThis study included 5732 infants delivered at <35 weeks of gestation born between 2005 and 2013 who were enrolled in the population-based Loire Infant Follow-up Team cohort and who had a neurodevelopmental evaluation at 2 years. This neurodevelopmental evaluation was based on a physical examination, a psychomotor evaluation and a parent-completed questionnaire.Outcome measureRisk of parental separation (parents living together or parents living separately).ResultsTen percent (572/5732) of the parents reported having undergone separation during the follow-up period. A mediation analysis showed that low gestational age had no direct effect on the risk of parental separation. Moreover, a non-optimal neurodevelopment at 2 years was associated with an increased risk of parental separation corresponding to a HR=1.49(1.23 to 1.80). Finally, the increased risk of parental separation was aggravated by low socioeconomic conditions.ConclusionsThe effect of low gestational age on the risk of parental separation was mediated by the infant’s neurodevelopment.

In vivo evidence by magnetic resonance volumetry of a gestational age dependent response to tracheal occlusion for congenital diaphragmatic hernia

2015 ◽  
Vol 35 (11) ◽  
pp. 1048-1056 ◽  
Author(s):  
Katika Nawapun ◽  
Mary Patrice Eastwood ◽  
Daysi Diaz-Cobos ◽  
Julio Jimenez ◽  
Michael Aertsen ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Gestational Age ◽  
Tracheal Occlusion ◽  
Age Dependent ◽  
Magnetic Resonance Volumetry

Prognosis of Neonates with Congenital Diaphragmatic Hernia Who Are Small for Gestational Age: A Multicenter Study

2019 ◽  
Vol 229 (4) ◽  
pp. S214
Author(s):  
Ariela L. Zenilman ◽  
Kenneth S. Azarow ◽  
Timothy M. Crombleholme ◽  
George B. Mychaliska ◽  
Brad Warner ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Multicenter Study ◽  
Gestational Age ◽  
Small For Gestational Age

scholarly journals Evolution of circulating thyroid hormone levels in preterm infants during the first week of life: perinatal influences and impact on neurodevelopment

2019 ◽  
Vol 32 (6) ◽  
pp. 597-606 ◽  
Author(s):  
An Eerdekens ◽  
Gunnar Naulaers ◽  
Els Ortibus ◽  
Johan Verhaeghe ◽  
Lies Langouche ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Preterm Infants ◽  
Gestational Age ◽  
Infant Development ◽  
Neurodevelopmental Outcome ◽  
Thyroid Stimulating Hormone ◽  
Low T3 ◽  
Increased Risk ◽  
Total Thyroxine ◽  
The Impact

Abstract Background For several decades, transient hypothyroxinemia of prematurity (THOP) has been a topic of debate. The pathophysiology is incompletely understood and consensus on the therapeutic approach is lacking. This study aimed at gaining a better insight into the pathogenesis by studying the trends in thyroid hormone (TH) levels during the first week of life. Methods This single-center prospective observational study analyzed the plasma levels of total thyroxine (T4) and free thyroxine (fT4), total triiodothyronine (T3), thyroid-stimulating hormone (TSH) and T4-binding globulin (TBG) in cord blood and at the end of the first week of life in 120 preterm infants (gestational age [GA] <37 weeks). The change over time was calculated (delta, ∆). The impact of perinatal and subsequently postnatal variables on ∆ was studied by hierarchical multiple regression. The impact of ∆ on the neurodevelopmental outcome at the corrected ages of 9 and 24 months, measured by the Bayley Scales of Infant Development (BSID)-II, was assessed by logistic regression. Results ∆fT4 levels were negatively affected by GA and use of dopamine, whereas only GA was associated with low ∆T3 levels. Negative ∆fT4 levels were present in 75% of the extremely low-for-gestational-age infants, whereas 23.5% had a negative ∆T3 level. There was an increased risk for an abnormal mental developmental score (<85) with decreasing ∆T3 at 9 months, corrected age, but not at 24 months. Conclusions A negative evolution in circulating TH levels is principally an immaturity phenomenon, whereas dopamine can further suppress the hypothalamic-pituitary-thyroid axis. There is at least a temporary negative effect of this evolution on the infants’ neurodevelopment.

scholarly journals Neonatal neuroimaging after repair of congenital diaphragmatic hernia and long-term neurodevelopmental outcome

2019 ◽  
Vol 2 (3) ◽  
pp. e000037
Author(s):  
Julia Kate Gunn-Charlton ◽  
Alice C Burnett ◽  
Stephanie Malarbi ◽  
Margaret M Moran ◽  
Esther A Hutchinson ◽  
...  
Keyword(s):  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Language Impairment ◽  
Neurodevelopmental Outcome ◽  
White Matter Injury ◽  
Scan Time ◽  
Mri Scans ◽  
Cerebral Ultrasound ◽  
Neurodevelopmental Impairment ◽  
Clinically Significant

ObjectivePrevious outcome reports of congenital diaphragmatic hernia (CDH) have described neuroimaging anomalies and neurodevelopmental impairment. However, the link between imaging and outcome has not been described. We aimed to determine whether routine postoperative neonatal neuroimaging in infants with CDH detects later neurodevelopmental impairment.MethodsIn a prospective cohort study within a clinical service in The Royal Children’s Hospital Newborn Intensive Care. Cerebral ultrasound was performed in 81 children and MRI in 57 children who subsequently underwent neurodevelopmental follow-up after surgery for CDH. MRI scans were analyzed using a scoring system designed to identify injury, maturation and volume loss. Neurodevelopmental assessment occurred at 2 years (48) and neurocognitive assessment at 5 years (26) and/or 8 years (27). Brain imaging scores corrected for gestational age at scan time were correlated with outcome measures, adjusting for known clinical confounders.ResultsClinically significant findings were identified on MRI of 16 (28%) infants. Mean scores were in the normal range for all domains assessed at each age. Language impairment was seen in 23% at 2 years and verbal intellectual impairment in 25% at 8 years. Mean cognitive scores were lower in 2-year-old children with white matter injury on MRI (p=0.03). Mean motor scores were lower in 2-year-old children with brain immaturity (p=0.01). Associations between MRI and 5-year and 8-year assessments were no longer significant when adjusting for known clinical confounders.ConclusionsNeuroimaging abnormalities were associated with worse neurodevelopment at 2 years, but not with later neurocognitive outcomes, after accounting for clinical risk factors.

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