Impacts of solvation on photo-damage of polypeptides: Modulation and biological implications

2021 ◽  
pp. 112214
Author(s):  
Chao Yang ◽  
Yue Meng ◽  
Bo Xie ◽  
Shengjie Xia
Keyword(s):  
Photo Damage

The Aging Face: A Different Perspective on Pathology and Treatment

1998 ◽  
Vol 15 (2) ◽  
pp. 167-172 ◽  
Author(s):  
Mark Berman
Keyword(s):  
Fat Grafting ◽  
Volume Correction ◽  
Brow Lift ◽  
Aging Face ◽  
Photo Damage ◽  
Lifting Techniques ◽  
Orbital Rim ◽  
Over Time

Probably because the thrust of the pathology of the aging face has been attributed to the effects of gravity (skin and muscle loosening and falling), treatment of such is generally directed toward lifting procedures. Indeed, results from such procedures are generally beneficial, but in many cases the patient appears unnaturally skeletonized. A brow-lift may eliminate some wrinkles and frown lines, but does anyone (naturally youthful) really have eyebrows a centimeter above the orbital rim? Our goal has been, and continues to be, to strive for excellence, and in the case of the aging face, this would be an improved and more youthful appearance. This paper will discuss the main pathology of the appearance of aging, which is the general dissipation of facial fat over time. It will also provide discussion as to thoughtful correction of the problem not only with lifting techniques but also with consideration to filling procedures. The judicial use of fat-grafting and various synthetic implants serve as the principal tools for volume correction. It is acknowledged that the skin undergoes photo-damage, which also contributes to the appearance of aging, but this is treated by treating the skin in a multitude of ways.

scholarly journals Photo-damage, photo-protection and age-related macular degeneration

2015 ◽  
Vol 14 (9) ◽  
pp. 1560-1577 ◽  
Author(s):  
Melisa D. Marquioni-Ramella ◽  
Angela M. Suburo
Keyword(s):  
Oxidative Stress ◽  
Retinal Pigment Epithelium ◽  
Macular Degeneration ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Molecular Targets ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Photo Damage ◽  
Effect Of Light

The course of Age-related Macular Degeneration (AMD) is described as the effect of light (400–580 nm) on various molecular targets in photoreceptors and the retinal pigment epithelium (RPE). Photo-damage is followed by inflammation, increasing oxidative stress and, probably, unveiling new photosensitive molecules.

Protective effect of melatonin on photo-damage to lysozyme

2009 ◽  
Vol 94 (2) ◽  
pp. 125-130 ◽  
Author(s):  
Hongping Zhu ◽  
Shimou Chen ◽  
Side Yao ◽  
Wenfeng Wang
Keyword(s):  
Protective Effect ◽  
Photo Damage

Growth and Holographic Storage Properties of Zr:Mn:Fe:LiNbO3 Crystal

2015 ◽  
Vol 731 ◽  
pp. 129-132
Author(s):  
Yi Ran Nie ◽  
Zhi Hui Sun ◽  
Jiang Chang ◽  
Li Juan An ◽  
Zhuang Liu
Keyword(s):  
Response Time ◽  
Diffraction Efficiency ◽  
Czochralski Method ◽  
Absorption Peak ◽  
Transmission Spectra ◽  
Infrared Transmission ◽  
Holographic Storage ◽  
Wave Coupling ◽  
Photo Damage ◽  
Storage Properties

Doping different concentration of ZrO2in Mn:Fe:LiNbO3crystals, a series of Zr:Mn:Fe:LiNbO3crystals were grown by the Czochralski method. The infrared transmission spectra and the photo-damage resistant ability of the crystals were measured. The OH-absorption peak of Zr (2mol%):Mn:Fe:LiNbO3crystal shifts to ultraviolet. The photo-damage resistant ability of Zr (3mol%):Mn:Fe:LiNbO3crystal is about three orders of magnitude higher than that of Mn:Fe:LiNbO3crystals. The diffraction efficiency, response time of Zr:Mn:Fe:LiNbO3crystals were measured by two-wave coupling experiment. The response time of Zr (3mol%):Mn:Fe:LiNbO3crystal is only one tenth of that of Mn:Fe:LiNbO3. The mechanism of OH-absorption peak shifting and improvement of holographic storage properties was discussed.

Enhancement of Protective Effects of Radix Scutellariae on UVB-induced Photo Damage in Human HaCaT Keratinocytes

2017 ◽  
Vol 184 (4) ◽  
pp. 1073-1093 ◽  
Author(s):  
Yu-shuai Wang ◽  
Jin-Gyeong Cho ◽  
Eun-Son Hwang ◽  
Jung-Eun Yang ◽  
Wei Gao ◽  
...  
Keyword(s):  
Protective Effects ◽  
Hacat Keratinocytes ◽  
Radix Scutellariae ◽  
Photo Damage

scholarly journals Deciphering the Genome Protection Roles of Autophagy in Primary Human Dermal Fibroblasts (HDFs) against Ultraviolet-(B) –Induced Skin Photodamage

2020 ◽  
Author(s):  
Sheikh Ahmad Umar ◽  
Sheikh Abdullah Tasduq
Keyword(s):  
Dna Damage ◽  
Stress Response ◽  
Er Stress ◽  
Dna Damage Response ◽  
Dermal Fibroblasts ◽  
Ultraviolet B ◽  
Great Promise ◽  
Er Stress Response ◽  
Damage Response ◽  
Photo Damage

AbstractUltraviolet-B (UV-B) exposure to skin causes photo-damage and acts as the primary etiological agent in photo-carcinogenesis. UV-B exposure induces photodamage in epidermal cells and is the major factor that challenges skin homeostasis. Autophagy allows fundamental adaptation of cells to metabolic needs and stresses. Cellular dysfunction is observed in aged tissues and in toxic insults to cells that undergo through stress. Conversely, promising anti-aging strategies aimed at inhibiting the mTOR pathway has been found to significantly improve the aging related disorders. Recently, autophagy has been found to positively regulate skin homeostasis by enhancing DNA damage recognition. Here we investigated the Geno-protective roles of autophagy in UV-B exposed primary HDFs. We found that improving autophagy levels in HDFs regulates UV-B mediated cellular stress by decreasing the formation of DNA photo adducts, alleviates oxidative and ER stress response and by regulating the expression levels of cell cycle regulatory proteins P21 and P27. Autophagy also prevents HDFs from UV-B -induced nuclear damage as is evident from Tunnel assay and Acridine Orange/Ethidium Bromide co-staining. Salubrinal, (an eIf2α inhibitor) significantly decreases the DNA damage response in HDFs. P62 silenced HDFs show enhanced DNA damage response and disturbs the tumor suppressor axis PTEN/pAKT towards damage whereas ATG7 silenced HDFs reveal an unexpected consequence by decreasing the UV-B -induced DNA damage compared to UV-B treated HDFs. Together, our results suggest that autophagy is essential in protecting skin cells from UV-B radiation -induced photo-damage and holds great promise in devising it as a suitable therapeutic strategy against skin photo-damage.HighlightsAutophagy is an immediate molecular event induced following exposure of primary HDFs to UV-B –irradiationAutophagy offers pro-survival capacity to HDFs under UV-B induced genotoxic stressAutophagy regulates DNA Damage Response via regulation of oxidative and ER stress in UV-B exposed HDFsRelieving ER stress response offers significant protection to primary HDFs from UV-B by decreasing the DNA damageAutophagy deprivation to HDFs via P62 silencing potentiates UV-B -induced DNA damage responseATG7 silencing in UV-B exposed HDFs unexpectedly alleviates the DNA Damage Response in primary HDFs

Sign in / Sign up

Export Citation Format

Share Document