scholarly journals Intermittent fasting from dawn to sunset for 30 consecutive days is associated with anticancer proteomic signature and upregulates key regulatory proteins of glucose and lipid metabolism, circadian clock, DNA repair, cytoskeleton remodeling, immune system and cognitive function in healthy subjects

2020 ◽  
Vol 217 ◽  
pp. 103645 ◽  
Author(s):  
Ayse L. Mindikoglu ◽  
Mustafa M. Abdulsada ◽  
Antrix Jain ◽  
Jong Min Choi ◽  
Prasun K. Jalal ◽  
...  
Keyword(s):  
Dna Repair ◽  
Immune System ◽  
Lipid Metabolism ◽  
Cognitive Function ◽  
Circadian Clock ◽  
Healthy Subjects ◽  
Regulatory Proteins ◽  
Intermittent Fasting ◽  
Glucose And Lipid Metabolism ◽  
Cytoskeleton Remodeling

Effects of Two Fat-Modified Diets on Glucose and Lipid Metabolism in Healthy Subjects

1993 ◽  
Vol 683 (1 Dietary Lipid) ◽  
pp. 279-280 ◽  
Author(s):  
URSULA SCHWAB ◽  
MATTI UUSITUPA ◽  
PAULI KARHAPÄÄ ◽  
SARI MÄKIMATTILA ◽  
MINNA RÄSÄNEN ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Healthy Subjects ◽  
Glucose And Lipid Metabolism

scholarly journals Immune and metabolic beneficial effects of Beta 1,3-1,6 glucans produced by two novel strains of Aureobasidium pullulans in healthy middle-aged Japanese men: An exploratory study

2021 ◽  
Author(s):  
Nobunao Ikewaki ◽  
Tohru Sonoda ◽  
Gene Kurosawa ◽  
Masaru Iwasaki ◽  
Vidyasagar Devaprasad Dedeepiya ◽  
...  
Keyword(s):  
Immune System ◽  
Lipid Metabolism ◽  
Blood Glucose ◽  
Aureobasidium Pullulans ◽  
Beta Glucan ◽  
Beneficial Effects ◽  
Glucose And Lipid Metabolism ◽  
Group I ◽  
Immune Enhancement ◽  
Group Ii

Background: Imbalances in glucose and lipid metabolism in the background of a declining immune system, along with aging, make one prone to glucolipotoxicity-related diseases such as hepatic steatosis and to high risk of infection-related mortality, as with COVID-19, warranting a safe prophylactic measure to help regulate both metabolism and the immune system. Based on the beneficial effects of the AFO-202 strain of black yeast Aureobasidium pullulans-produced beta 1,3-1,6 glucan in balancing of blood glucose and immune enhancement, and that of the N-163 strain of the same species in lipid metabolism and immune modulation, in this pilot study, we have evaluated their specific benefits in healthy human subjects. Methods: Sixteen healthy Japanese male volunteers (aged 40 to 60 years) took part in this clinical trial. They were divided into four groups (n = 4 each): Group I consumed AFO-202 beta glucan (2 sachets of 1 g each per day), IA for 35 days and IB for 21 days; Group II consumed a combination of AFO-202 beta glucan (2 sachets of 1 g each) and N-163 beta glucan (1 sachet of 15 g gel each per day), IIA for 35 days and IIB for 21 days. Investigations for immune stimulation, anti-glycaemic, and anti-cholesterolemia biomarkers were undertaken in all four groups. Results: In terms of metabolic control of glucose, the decrease in HbA1C and glycated albumin (GA) was significantly better in Group I compared with the other groups. Immune enhancement in terms of a significant increase of eosinophils and monocytes and marginal decrease in D-dimer levels, decrease in neutrophil-to-lymphocyte ratio (NLR), with an increase in the lymphocyte-to-CRP ratio (LCR) and leukocyte-to-CRP ratio (LeCR) was observed in Group I. Regulation of lipids by decrease in total and LDL cholesterol was better in Group II, and immunomodulation of coagulation-associated and anti-inflammatory markers by a decrease of CD11b, serum ferritin, galectin-3, fibrinogen was profound in Group II. Conclusion: A. pullulans, a polythermotolerant black yeast - produced AFO-202 beta glucan has balanced blood glucose with marginal immune enhancement in healthy individuals, which when combined with N-163 beta glucan, balanced the lipid profile and immunomodulation. This outcome warrants larger clinical trials to understand the mechanisms and explore the potentials of these safe food supplements in prevention and prophylaxis of diseases due to dysregulated glucose and lipid metabolism, such as fatty liver disease, and infections such as COVID-19 in which a balanced immune activation and immunomodulation are of utmost importance, besides their administration as an adjunct to existing therapeutic approaches of both communicable and non-communicable diseases.

scholarly journals Effects of intermittent fasting on glucose and lipid metabolism

2017 ◽  
Vol 76 (3) ◽  
pp. 361-368 ◽  
Author(s):  
Rona Antoni ◽  
Kelly L. Johnston ◽  
Adam L. Collins ◽  
M. Denise Robertson
Keyword(s):  
Lipid Metabolism ◽  
Energy Restriction ◽  
Human Studies ◽  
Future Research ◽  
Intermittent Fasting ◽  
Glucose And Lipid Metabolism ◽  
Safety Studies ◽  
Similar Weight ◽  
Glucose And Lipid Homeostasis

Two intermittent fasting variants, intermittent energy restriction (IER) and time-restricted feeding (TRF), have received considerable interest as strategies for weight-management and/or improving metabolic health. With these strategies, the pattern of energy restriction and/or timing of food intake are altered so that individuals undergo frequently repeated periods of fasting. This review provides a commentary on the rodent and human literature, specifically focusing on the effects of IER and TRF on glucose and lipid metabolism. For IER, there is a growing evidence demonstrating its benefits on glucose and lipid homeostasis in the short-to-medium term; however, more long-term safety studies are required. Whilst the metabolic benefits of TRF appear quite profound in rodents, findings from the few human studies have been mixed. There is some suggestion that the metabolic changes elicited by these approaches can occur in the absence of energy restriction, and in the context of IER, may be distinct from those observed following similar weight-loss achieved via modest continuous energy restriction. Mechanistically, the frequently repeated prolonged fasting intervals may favour preferential reduction of ectopic fat, beneficially modulate aspects of adipose tissue physiology/morphology, and may also impinge on circadian clock regulation. However, mechanistic evidence is largely limited to findings from rodent studies, thus necessitating focused human studies, which also incorporate more dynamic assessments of glucose and lipid metabolism. Ultimately, much remains to be learned about intermittent fasting (in its various forms); however, the findings to date serve to highlight promising avenues for future research.

1060-P: The Effect of FGF21/GLP-1 Fusion Protein on Glucose and Lipid Metabolism Using Diabetic Mice Models

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1060-P
Author(s):  
LIXIN GUO ◽  
QI PAN ◽  
CHAO CHEN ◽  
SHUSHAN LIN ◽  
YU LI ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Fusion Protein ◽  
Diabetic Mice ◽  
Glucose And Lipid Metabolism

1878-P: The Role and Potential Mechanism of LncRNA Gm15441 in Skeletal Muscle Glucose and Lipid Metabolism

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1878-P
Author(s):  
LIANGHUI YOU ◽  
YU ZENG ◽  
NAN GU ◽  
CHENBO JI
Keyword(s):  
Skeletal Muscle ◽  
Lipid Metabolism ◽  
Potential Mechanism ◽  
Glucose And Lipid Metabolism
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