The incidence of metabolic syndrome and its reversal in a cohort of schizophrenic patients followed for one year

AbstractThis study examines if overweight/obesity are related to higher impulsivity, food addiction and depressive symptoms, and if these variables could be modified after 1 year of a multimodal intervention (diet, physical activity, psychosocial support). 342 adults (55–75 years) with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus Cognition study were randomized to the intervention or to the control group (lifestyle recommendations). Cognitive and psychopathological assessments were performed at baseline and after 1-year follow-up. At baseline, higher impulsivity was linked to higher food addiction and depressive symptoms, but not to body mass index (BMI). Food addiction not only predicted higher BMI and depressive symptoms, but also achieved a mediational role between impulsivity and BMI/depressive symptoms. After 1 year, patients in both groups reported significant decreases in BMI, food addiction and impulsivity. BMI reduction and impulsivity improvements were higher in the intervention group. Higher BMI decrease was achieved in individuals with lower impulsivity. Higher scores in food addiction were also related to greater post-treatment impulsivity. To conclude, overweight/obesity are related to higher impulsivity, food addiction and depressive symptoms in mid/old age individuals with MetS. Our results also highlight the modifiable nature of the studied variables and the interest of promoting multimodal interventions within this population.

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One-year follow-up of schizophrenic patients treated with Risperidone or classical neuroleptics: a prospective, randomized, multicentered open-study

European Neuropsychopharmacology ◽

10.1016/s0924-977x(98)80455-0 ◽

1998 ◽

Vol 8 ◽

pp. S253 ◽

Cited By ~ 3

Author(s):

R.H. Bouchard ◽

E. Pourcher ◽

C. Mérette ◽

M.F. Demers ◽

J. Villeneuve ◽

...

Keyword(s):

Open Study ◽

Schizophrenic Patients ◽

One Year

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One-year follow-up study on associations between dental caries, periodontitis, and metabolic syndrome

Journal of Oral Science ◽

10.2334/josnusd.18-0251 ◽

2020 ◽

Vol 62 (1) ◽

pp. 52-56 ◽

Cited By ~ 2

Author(s):

Naoko Adachi ◽

Yasuki Kobayashi

Keyword(s):

Metabolic Syndrome ◽

Dental Caries ◽

Follow Up Study ◽

One Year

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Schizophrenic Patients and their Families a Survey in a Psychiatric service based on a DGH Unit

The British Journal of Psychiatry ◽

10.1192/bjp.144.1.70 ◽

1984 ◽

Vol 144 (1) ◽

pp. 70-77 ◽

Cited By ~ 155

Author(s):

J. S. Gibbons ◽

S. H. Horn ◽

J. M. Powell ◽

J. L. Gibbons

Keyword(s):

Social Performance ◽

Adult Population ◽

Psychiatric Service ◽

District General Hospital ◽

Drop Out ◽

Subjective Distress ◽

Private Households ◽

High Prevalence ◽

Schizophrenic Patients ◽

One Year

SummaryWe identified the population of schizophrenic patients under 65 in a geographically defined area. The number using psychiatric services based on a new District General Hospital unit in the course of one year was 364, a prevalence of 2.2 per 1000 adult population. Half the patients lived in supportive private households, most often with spouses or mothers. More women than men married and retained supporters. Patients and their primary supporters were interviewed separately. The PSE Catego programme classed 47 per cent of patients as psychotic. Supporters reported disturbed behaviour in 65 per cent of patients, and restricted social performance in 78 per cent. There was evidence of hardship (emotional and physical ill-health, problems with children) in 90 per cent of households. Supporters' subjective distress was directly related to the presence of psychosis and disturbed behaviour and inversely related to the duration of the illness. Drop-out and failure to take medication appeared to be causes of the relatively high prevalence of psychosis.

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Mental Disorder and Season of Birth: Comparison of Psychoses with Neurosis

The British Journal of Psychiatry ◽

10.1192/bjp.115.522.533 ◽

1969 ◽

Vol 115 (522) ◽

pp. 533-540 ◽

Cited By ~ 39

Author(s):

E. H. Hare ◽

J. S. Price

Keyword(s):

General Population ◽

Birth Rate ◽

Season Of Birth ◽

Significant Excess ◽

Seasonal Influence ◽

Manic Depressive ◽

Single Exception ◽

Schizophrenic Patients ◽

One Year ◽

Depressive Patients

Barry and Barry (1961, 1964) have reviewed the evidence for an association between season of birth and the major psychoses. Their figures show that, with a single exception, every study has found an excess (though not always a significant excess) of schizophrenic and manic-depressive patients born between January and April, and a deficit born between May and August, compared with the control populations. The single exception was their own study (1964) on schizophrenic patients in private mental hospitals, a finding which led them to conclude either that the private class of patient is protected from some adverse seasonal influence or that schizophrenic patients come chiefly from a subgroup of the population which has a comparatively high birth rate during the first four months of the year. Norris and Chowning (1962) drew attention to the fact that the seasonal distribution of births in a general population may vary appreciably from year to year in a particular country and from place to place within that country in any one year, and suggested that such variations make difficult any comparison between births of patients and of a large general population taken over a number of years, the procedure which had hitherto been adopted.

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Lithium withdrawal Trial in Chronic Schizophrenia

The British Journal of Psychiatry ◽

10.1192/bjp.141.4.401 ◽

1982 ◽

Vol 141 (4) ◽

pp. 401-406 ◽

Cited By ~ 8

Author(s):

N. J. Delva ◽

F. J. J. Letemendia ◽

A. W. Prowse

Keyword(s):

Chronic Schizophrenia ◽

Schizophrenic Patients ◽

One Year ◽

Lithium Withdrawal

SummarySix schizophrenic patients treated with lithium and neuroleptics for at least two years had their lithium medication stopped. Two patients relapsed within two weeks, and four did not after one year of follow-up.

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A CASE STUDY ON SCHIZOPHRENIA INDUCED MULTIPLE COMORBIDITIES

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i6.23979 ◽

2018 ◽

Vol 11 (6) ◽

pp. 1

Author(s):

Jagadeesan M ◽

Kiran Kumar R ◽

Justin Jacob Abraham

Keyword(s):

Diabetes Mellitus ◽

Metabolic Syndrome ◽

Antipsychotic Drugs ◽

Hypoglycemic Agents ◽

Systemic Hypertension ◽

Inferior Wall ◽

Cardiovascular Risks ◽

Coronary Syndrome ◽

Schizophrenic Patients

Schizophrenia is a mental disorder characterized by abnormal social behavior which includes false beliefs, confusion, and auditory hallucination. Antipsychotic drugs therapy increases the risk of developing diabetes mellitus and coronary artery disease (CAD) in schizophrenic patients. Hence, we have planned for a systematic approach toward the management of comorbidities induced in schizophrenic patients. A case study was conducted in 42-year-old female patient diagnosed with schizophrenia along with Type-2 diabetes mellitus, hypothyroidism, diabetic retinopathy, diabetic nephropathy, systemic hypertension, CAD-acute coronary syndrome recent inferior wall myocardial infarction. The patient was treated with atypical antipsychotics, antiplatelets, antianginals, statins, hypoglycemic agents, and other supportive measures. The patient improved symptomatically. The antipsychotic treatment for schizophrenia induces abnormal metabolic syndrome which results in decreased glucose and lipid metabolism that leads to obesity, hyperglycemia, and dyslipidemia associated with cardiovascular risks. Often antipsychotics are combined with benzodiazepines and antiparkinson agents to reduce the risks caused from large doses of antipsychotic medication. However, people receiving first-generation antipsychotics have higher prevalence of developing diabetes mellitus and cardiac risks compared to second-generation antipsychotics. Hence, we conclude that atypical antipsychotic drugs such as amisulpride, aripiprazole, and ziprasidone should be given to schizophrenic patients because these drugs have little effects on abnormal metabolic syndrome when compared to other antipsychotics. There is a need for proper screening of blood glucose level and cardiovascular risks assessment before the administration of antipsychotic medications to schizophrenic patients and also during the course of treatment regularly.

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