Follow-up study of clinical and chest CT scans in confirmed COVID-19 patients

Objective: The pulmonary sequelae of coronavirus disease 2019 (COVID-19) have not been comprehensively evaluated. We performed a follow-up study analyzing chest computed tomography (CT) findings of COVID-19 patients at 3 and 6 months after hospital discharge.Methods: Between February 2020 and May 2020, a total of 273 patients with COVID-19 at the Shenzhen Third People's Hospital were recruited and followed for 6 months after discharge. Chest CT scanning was performed with the patient in the supine position at end-inspiration. A total of 957 chest CT scans was obtained at different timepoints. A semi-quantitative score was used to assess the degree of lung involvement.Results: Most chest CT scans showed bilateral lung involvement with peripheral location at 3 and 6 months follow-up. The most common CT findings were ground-glass opacity and parenchymal band, which were found in 136 (55.3%) and 94 (38.2%) of the 246 patients at 3 months follow-up, and 82 (48.2%) and 76 (44.7%) of 170 patients at 6 months follow-up, respectively. The number of lobes involved and the total CT severity score declined over time. The total CT score gradually increased with the increasement of disease severity at both 3 months follow-up (trend test P < 0.001) and 6 months follow-up (trend test P < 0.001). Patients with different disease severity represented diverse CT patterns over time.Conclusions: The most common CT findings were ground-glass opacity and parenchymal bands at the 3 and 6 months follow-up. Patients with different disease severity represent diverse CT manifestations, indicating the necessary for long-term follow-up monitoring of patients with severe and critical conditions.

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Cross-sectional analysis of follow-up chest MRI and chest CT scans in patients previously affected by COVID-19

La radiologia medica ◽

10.1007/s11547-021-01390-4 ◽

2021 ◽

Author(s):

Martina Pecoraro ◽

Stefano Cipollari ◽

Livia Marchitelli ◽

Emanuele Messina ◽

Maurizio Del Monte ◽

...

Keyword(s):

Chest Ct ◽

Ct Scans ◽

Imaging Biomarker ◽

Cross Sectional ◽

Mri Scans ◽

Magnetic Resonance Imaging Mri ◽

Sectional Analysis ◽

Ct And Mri ◽

Interlobular Septal Thickening

Abstract Purpose The aim of the study was to prospectively evaluate the agreement between chest magnetic resonance imaging (MRI) and computed tomography (CT) and to assess the diagnostic performance of chest MRI relative to that of CT during the follow-up of patients recovered from coronavirus disease 2019. Materials and methods Fifty-two patients underwent both follow-up chest CT and MRI scans, evaluated for ground-glass opacities (GGOs), consolidation, interlobular septal thickening, fibrosis, pleural indentation, vessel enlargement, bronchiolar ectasia, and changes compared to prior CT scans. DWI/ADC was evaluated for signal abnormalities suspicious for inflammation. Agreement between CT and MRI was assessed with Cohen’s k and weighted k. Measures of diagnostic accuracy of MRI were calculated. Results The agreement between CT and MRI was almost perfect for consolidation (k = 1.00) and change from prior CT (k = 0.857); substantial for predominant pattern (k = 0.764) and interlobular septal thickening (k = 0.734); and poor for GGOs (k = 0.339), fibrosis (k = 0.224), pleural indentation (k = 0.231), and vessel enlargement (k = 0.339). Meanwhile, the sensitivity of MRI was high for GGOs (1.00), interlobular septal thickening (1.00), and consolidation (1.00) but poor for fibrotic changes (0.18), pleural indentation (0.23), and vessel enlargement (0.50) and the specificity was overall high. DWI was positive in 46.0% of cases. Conclusions The agreement between MRI and CT was overall good. MRI was very sensitive for GGOs, consolidation and interlobular septal thickening and overall specific for most findings. DWI could be a reputable imaging biomarker of inflammatory activity.

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Muscle CT scans in neuromuscular diseases: a follow-up study

Neuromuscular Disorders ◽

10.1016/s0960-8966(97)87349-x ◽

1997 ◽

Vol 7 (6-7) ◽

pp. 473 ◽

Cited By ~ 1

Author(s):

Giampiero Marconi ◽

Assunta Pizzi ◽

Ibrahim Mahjneh

Keyword(s):

Neuromuscular Diseases ◽

Ct Scans ◽

Follow Up Study ◽

Muscle Ct

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Mo1490 Annual CT Scans Do Not Improve Survival Following Oesphagectomy for Cancer: A Follow up Study of 126 Patients

Gastroenterology ◽

10.1016/s0016-5085(12)64182-1 ◽

2012 ◽

Vol 142 (5) ◽

pp. S-1076-S-1077

Author(s):

Stefan S. Antonowicz ◽

Bruno Lorenzi ◽

Adriana Rotundo ◽

Cheuk Bong Tang ◽

Michael Harvey ◽

...

Keyword(s):

Ct Scans ◽

Follow Up Study

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The Pulmonary Sequalae in Discharged Patients With COVID-19:A Short-term Observational Study

10.21203/rs.3.rs-21985/v2 ◽

2020 ◽

Author(s):

Dehan Liu ◽

Wanshu Zhang ◽

Feng Pan ◽

Lin Li ◽

Lian Yang ◽

...

Keyword(s):

Chest Ct ◽

Ct Scans ◽

Optimal Time ◽

Imaging Features ◽

Short Term ◽

Lung Lesions ◽

Cumulative Percentage ◽

Time Points ◽

Time Point

Abstract Background: A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia were discharged from hospitals in Wuhan, China. We aimed to determine the cumulative percentage of complete radiological resolution at each time point, to explore the relevant affecting factors, and to describe the chest CT findings at different time points after hospital discharge.Methods: Patients with COVID-19 pneumonia confirmed by RT-PCR who were discharged consecutively from the hospital between 5 February 2020 and 10 March 2020 and who underwent serial chest CT scans on schedule were enrolled. The radiological characteristics of all patients were collected and analysed. The total CT score was the sum of non-GGO involvement determined at discharge. Afterwards, all patients underwent chest CT scans during the 1st, 2nd, and 3rd weeks after discharge. Imaging features and distributions were analysed across different time points.Results: A total of 149 patients who completed all CT scans were evaluated; there were 67 (45.0%) men and 82 (55.0%) women, with a median age of 43 years old (IQR 36-56). The cumulative percentage of complete radiological resolution was 8.1% (12 patients), 41.6% (62), 50.3% (75), and 53% (79) at discharge and during the 1st, 2nd, and 3rd weeks after discharge, respectively. Patients ≤44 years old showed a significantly higher cumulative percentage of complete radiological resolution than patients >44 years old at the 3-week follow-up. The predominant patterns of abnormalities observed at discharge were ground-glass opacity (GGO) (65 [43.6%]), fibrous stripe (45 [30.2%]), and thickening of the adjacent pleura (16 [10.7%]). Lung lesions showed obvious resolution from 2 to 3 weeks after discharge, especially in terms of GGO and fibrous stripe. “Tinted” sign and bronchovascular bundle distortion as two special features were discovered during the evolution.Conclusion: Lung lesions in COVID-19 pneumonia patients can be absorbed completely during short-term follow-up with no sequelae. Three weeks after discharge might be the optimal time point for early radiological estimation.

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Solid Indeterminate Pulmonary Nodules Less Than or Equal to 250 mm3: Application of the Updated Fleischner Society Guidelines in Clinical Practice

Radiology Research and Practice ◽

10.1155/2019/7218258 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 4

Author(s):

Andrea Borghesi ◽

Silvia Michelini ◽

Giorgio Nocivelli ◽

Mario Silva ◽

Alessandra Scrimieri ◽

...

Keyword(s):

Doubling Time ◽

Pulmonary Nodules ◽

Chest Ct ◽

Ct Scans ◽

Inclusion Criteria ◽

Histologic Diagnosis ◽

Indeterminate Nodules ◽

Risk Patients ◽

New Guidelines

Background. The latest version of the Fleischner Society guidelines for management of incidental pulmonary nodules was published in 2017. The main purpose of these guidelines is to reduce the number of unnecessary computed tomography (CT) examinations during the follow-up of small indeterminate nodules. Objective. The present study aimed to evaluate the performance of these guidelines for management of solid indeterminate pulmonary nodules (SIPNs) ≤ 250 mm3. Materials and Methods. During a 7-year period, we retrospectively reviewed the chest CT scans of 672 consecutive patients with SIPNs. The study sample was selected according to the following inclusion criteria: solitary SIPN; diameter ≥ 3 mm; volume ≤ 250 mm3; two or more CT scans performed with the same scanner and same acquisition/reconstruction protocol; thin-section 1-mm images in DICOM format; histologic diagnosis or follow-up ≥ 2 years; and no oncological history. Applying these criteria, a total of 27 patients with single SIPNs ≤ 250 mm3 were enrolled. For each SIPN, the volume and doubling time were calculated using semiautomatic software throughout the follow-up period. For each SIPN, we applied the Fleischner Society guidelines, and the recommended management was compared to what was actually done. Results. A significant volumetric increase was detected in 5/27 (18.5%) SIPNs; all growing nodules were observed in high-risk patients. In these SIPNs, a histologic diagnosis of malignancy was obtained. Applying the Fleischner Society recommendations, all five malignant nodules would have been identified. None of the SIPNs < 100 mm3 in low-risk patients showed significant growth during the follow-up period. The application of the new guidelines would have led to a significant reduction in follow-up CT examinations (Hodges-Lehmann median difference, -2 CT scans; p = 0.0001). Conclusion. The application of the updated Fleischner Society guidelines has been shown to be effective in the management of SIPNs ≤ 250 mm3 with a significant reduction in radiation dose.

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Value of Chest CT Scans in Routine Ovarian Carcinoma Follow-Up

American Journal of Roentgenology ◽

10.2214/ajr.177.4.1770857 ◽

2001 ◽

Vol 177 (4) ◽

pp. 857-859 ◽

Cited By ~ 20

Author(s):

T. Sella ◽

E. Rosenbaum ◽

D. Z. Edelmann ◽

R. Agid ◽

A. I. Bloom ◽

...

Keyword(s):

Ovarian Carcinoma ◽

Chest Ct ◽

Ct Scans

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RADIOLOGICAL RESOLUTION IN A SEVERE COVID PATIENT: A FOLLOW-UP STUDY

10.36106/ijsr/7219554 ◽

2020 ◽

pp. 65-67

Author(s):

K. Arun Vishnu ◽

Athul.C. Angaj ◽

Trinath Dash

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Pulmonary Fibrosis ◽

Respiratory Distress Syndrome ◽

Severity Score ◽

Distress Syndrome ◽

Viral Pneumonia ◽

Ct Scans ◽

Follow Up Study ◽

Over Time

PULMONARY FIBROSIS IS A FREQUENT COMPLICATION IN PATIENTS WITH VIRAL PNEUMONIA-INDUCED ACUTE RESPIRATORY DISTRESS SYNDROME. HOWEVER, CT SCANS HAVE SHOWN THAT THE SIGNS OF PULMONARY FIBROSIS AFTER VIRAL PNEUMONIA CAN PARTIALLY REGRESS OVER TIME. SO NOW A DAYS, AS A PART OF COVID TREATMENT, FOR PREVENTING FIBROSIS, WE ARE GIVING ANTI FIBROTICS AND STEROIDS. BUT WE DON’T KNOW THE ACTUAL SEQUALE OF LESIONS IN LUNG DUE TO COVID. HERE WE WOULD LIKE TO DISCUSS ABOUT OUR CASE OF SEVERE COVID-19 INFECTION WHO WAS MANAGED WITH ANTI-FIBROTICS, NIV, ANTI-VIRALS, STEROIDS AND PRONE VENTILATION. THIS PARTICULAR PATIENT HAD CT SEVERITY SCORE OF 21/25 WITH B/L GGOs, FIBROTIC BANDS AND CONSOLIDATORY CHANGES. A 1 MONTH FOLLOW-UP CT SCAN SHOWED A REDUCTION IN CT SEVERITY SCORE (15/25) AND GROSS RESOLUTION IN CONSOLIDATORY CHANGES AND GGOs. THE CLINICAL CONDITION SHOWED A SIGNIFICANT IMPROVEMENT.

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Spectrum of Chest Computerised Tomography (CT) findings of Covid 19 in Indian Population

PERSPECTIVES IN MEDICAL RESEARCH - 2 ◽

10.47799/pimr.0901.09 ◽

2021 ◽

Vol 9 (1) ◽

pp. 43-49

Author(s):

Shravya Boini ◽

Vikas Chennamaneni ◽

Vamshi Kiran Diddy ◽

Momin Sayed Kashif

Keyword(s):

Lower Lobe ◽

Ground Glass Opacity ◽

Ct Images ◽

Chest Ct ◽

Ct Scans ◽

Ground Glass ◽

Study Cohort ◽

Study Population ◽

Ct Features

Background: To analyze the chest computed tomography (CT) features in patients with coronavirus disease 2019 (COVID-19) pneumonia. Methods: This was a prospective descriptive study comprising 202 consecutive reverse transcriptase polymerase chain reaction (RT-PCR) positive patients who underwent CT chest. For 25 patients, follow-up CT scans were obtained. The CT images were evaluated for the number, type and distribution of the opacity, and CT severity scoring was done Results: Among the total study cohort of 202 patients, 152 were males and 50 were females .From July 07, 2020, to september07, 2020, totally 202 laboratory-confirmed patients with COVID-19 underwent chest CT. For 25 patients, follow-up CT scans were obtained. The CT images were evaluated for the number, type and distribution of the opacity, and the affected lung lobes. Furthermore, the initial CT scan and the follow-up CT scans were compared. Results were patients (98.5%) had two or more opacities in the lung and 3 (1.5%) patients has negative chest CT. 183 (90.6%) patients had only ground-glass opacities; 13 patients (6.4%) had ground-glass and consolidative opacities; and 3 patients (1.5%) had only consolidation. A total 192 of patients (96.5%) showed two or more lobes involved. The opacities tended to be both in peripheral and central 7 (3.5%) or purely peripheral distribution 192 (96.5%). 177 patients (88.9%) had the lower lobe involved.8 patients showed complete resolution of lung findings. Conclusion: In this study population, the typical CT features of COVID 19 pneumonia are ground glass opacity with or without consolidation, which is patchy and peripheral, predominantly in lower lobes.

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Clinical and Imaging features in COVID-19 Patients: Analysis of Data from Patients in Non-pandemic areas

10.21203/rs.3.rs-21373/v1 ◽

2020 ◽

Author(s):

Shengkun Peng ◽

Lingai Pan ◽

Shaojin Zhang ◽

Yalong Liu ◽

Hua Zhang ◽

...

Keyword(s):

Peripheral Zone ◽

Chest Ct ◽

Ct Scans ◽

Severe Illness ◽

Imaging Features ◽

Imaging Characteristics ◽

Number Of Patients ◽

Patient Will ◽

Acid Test

Abstract Purpose To describe the imaging characteristics in COVID-19 Patients from non-pandemic regions to improve understanding of the disease. Methods We reviewed chest CT scans of 30 COVID-19 patients from three hospitals in Sichuan province, China. Results Typical CT manifestations include the involvement of multiple lobes, mostly in the peripheral zone of the lungs, and subpleural distribution. GGO, crazy paving or mixed GGO and consolidation is the most common signs. Few patients can present small amount of pleural effusion. It is worth noting that none of the lung cavities, tree buds, and lymphadenopathy appeared. The follow-up imaging findings of some patients showed progress when the initial CT score reached 7. Conclusion The CT scan still play an important role in screening the COVID-19, most of the images present positive signs, mainly subpleural, multiple GGO. CT might can predict the severity or whether the patient will progress to severe illness. A small number of patients may be missed if they are based on CT findings alone, which should be closely combined with the patient's epidemiological history and nucleic acid test.

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