Boron influences immune and antioxidant responses by modulating hepatic superoxide dismutase activity under calcium deficit abiotic stress in Wistar rats

AbstractBackgroundQuinine (QT) is an important anti-malarial drug; however, there is little information about its effects on the gut. Therefore, this study aimed to investigate the effects of a therapeutic dose of QT on the healing of gastric ulcer in rats.MethodsMale Wistar rats weighing 150–200 g were divided into three groups: control rats without ulcer (group 1), ulcerated rats treated with 1 mL/kg (p.o.) normal saline (NS) (group 2), and ulcerated rats treated with 10 mg/kg (p.o.) QT (group 3). Ulcers were induced by serosal application of 80 % acetic acid to the stomach of rats anaesthetized with 50 mg/kg thiopentone sodium and treatment was given three times daily. Healing was assessed on days 3, 7 and 10 after ulcer induction by macroscopic measurement of: ulcer area, histology, lipid peroxidation, superoxide dismutase activity and gastric mucus secretion.ResultsAt day 3, there was no significant difference (p>0.05) in ulcer areas between NS- and QT-treated rats. By day 10, however, the percentage area healed in NS treated (59.6±2.35 %) was significantly higher (p<0.05) than in QT rats (49.0±2.20 %) and clearing of inflammatory cells and re-epithelization was greater in NS-treated group. By days 7 and 10, lipid peroxidation was significantly higher in QT animals, when compared with NS-treated rats and controls (p<0.05). Superoxide dismutase activity and mucus secretion were significantly (p<0.05) higher in NS-treated than QT-treated rats.ConclusionsQT delayed ulcer healing by prolonging the inflammatory phase of healing, increasing oxidative stress, reducing antioxidant activity and gastric mucus secretion

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Green Tea (Camellia sinensis) Protects Against Arsenic Neurotoxicity via Antioxidative Mechanism and Activation of Superoxide Dismutase Activity

Central Nervous System Agents in Medicinal Chemistry ◽

10.2174/1871524917666170201145102 ◽

2017 ◽

Vol 17 (3) ◽

Cited By ~ 7

Author(s):

Smarajit Maiti ◽

Nirmallya Acharyya ◽

Tamal K. Ghosh ◽

Sk. Sajed Ali ◽

Emili Manna ◽

...

Keyword(s):

Superoxide Dismutase ◽

Green Tea ◽

Camellia Sinensis ◽

Superoxide Dismutase Activity

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Diazoxide Modulates Cardiac Hypertrophy by Targeting H2O2 Generation and Mitochondrial Superoxide Dismutase Activity

Current Molecular Pharmacology ◽

10.2174/1874467212666190723144006 ◽

2020 ◽

Vol 13 (1) ◽

pp. 76-83

Author(s):

Aline Maria Brito Lucas ◽

Joana Varlla de Lacerda Alexandre ◽

Maria Thalyne Silva Araújo ◽

Cicera Edna Barbosa David ◽

Yuana Ivia Ponte Viana ◽

...

Keyword(s):

Oxidative Stress ◽

Superoxide Dismutase ◽

Cardiac Hypertrophy ◽

Superoxide Dismutase Activity ◽

Heart Weight ◽

Pharmacological Intervention ◽

Wall Thickening ◽

H2o2 Production ◽

Mitochondrial Superoxide ◽

Mitochondrial Superoxide Dismutase

Background: Cardiac hypertrophy involves marked wall thickening or chamber enlargement. If sustained, this condition will lead to dysfunctional mitochondria and oxidative stress. Mitochondria have ATP-sensitive K+ channels (mitoKATP) in the inner membrane that modulate the redox status of the cell. Objective: We investigated the in vivo effects of mitoKATP opening on oxidative stress in isoproterenol- induced cardiac hypertrophy. Methods: Cardiac hypertrophy was induced in Swiss mice treated intraperitoneally with isoproterenol (ISO - 30 mg/kg/day) for 8 days. From day 4, diazoxide (DZX - 5 mg/kg/day) was used in order to open mitoKATP (a clinically relevant therapy scheme) and 5-hydroxydecanoate (5HD - 5 mg/kg/day) or glibenclamide (GLI - 3 mg/kg/day) were used as mitoKATP blockers. Results: Isoproterenol-treated mice had elevated heart weight/tibia length ratios (HW/TL). Additionally, hypertrophic hearts had elevated levels of carbonylated proteins and Thiobarbituric Acid Reactive Substances (TBARS), markers of protein and lipid oxidation. In contrast, mitoKATP opening with DZX avoided ISO effects on gross hypertrophic markers (HW/TL), carbonylated proteins and TBARS, in a manner reversed by 5HD and GLI. Moreover, DZX improved mitochondrial superoxide dismutase activity. This effect was also blocked by 5HD and GLI. Additionally, ex vivo treatment of isoproterenol- induced hypertrophic cardiac tissue with DZX decreased H2O2 production in a manner sensitive to 5HD, indicating that this drug also acutely avoids oxidative stress. Conclusion: Our results suggest that diazoxide blocks oxidative stress and reverses cardiac hypertrophy. This pharmacological intervention could be a potential therapeutic strategy to prevent oxidative stress associated with cardiac hypertrophy.

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Complexation of Mn(II) by Rigid Pyclen Diacetates: Equilibrium, Kinetic, Relaxometric, Density Functional Theory, and Superoxide Dismutase Activity Studies

Inorganic Chemistry ◽

10.1021/acs.inorgchem.0c03276 ◽

2020 ◽

Author(s):

Zoltán Garda ◽

Enikő Molnár ◽

Nadège Hamon ◽

José Luis Barriada ◽

David Esteban-Gómez ◽

...

Keyword(s):

Density Functional Theory ◽

Superoxide Dismutase ◽

Density Functional ◽

Superoxide Dismutase Activity ◽

Functional Theory

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Two New Compounds From the Heartwood of Dalbergia melanoxylon and Their Protective Effect on Hypoxia/Reoxygenation Injury in H9c2

Natural Product Communications ◽

10.1177/1934578x20987776 ◽

2021 ◽

Vol 16 (1) ◽

pp. 1934578X2098777

Author(s):

Yang Liu ◽

Ni Zhang ◽

Jun-wei He ◽

Lan-ying Chen ◽

Li Yang ◽

...

Keyword(s):

Superoxide Dismutase ◽

Lactate Dehydrogenase ◽

Protective Effect ◽

Superoxide Dismutase Activity ◽

Spectral Evidence ◽

Reoxygenation Injury ◽

Dalbergia Melanoxylon ◽

New Compounds ◽

Hypoxia Reoxygenation

A new neoflavonoid, named as (7 R)-(-)-3′,5-dihydroxy-4′,2,4-trimethoxy-dalbergiquinol (1) and a new phenanthrenedione, named as 3′,7-dihydroxy-3,6- dimethoxy-9-phenyl-1,4-phenanthrenedione (2), together with 4 known compounds, 5- O-methyldalbergiphenol (3), 3′,7-dihydroxy-4′,3,6-trimethoxy-9-phenyl-1,4-phenanthrenedione (4), (+)-obtusafuran (5), and melanoxin (6) were isolated from the heartwood of Dalbergia melanoxylon. Their structures were elucidated on the basis of chemical and spectral evidence, as well as by comparison with literature data. Moreover, compound 1 showed a protective effect on hypoxia/reoxygenation injury in H9c2 at 10.0 μM by decreasing lactate dehydrogenase and malondialdehyde activity and enhancing superoxide dismutase activity.

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