Supraclavicular skin temperature measured by iButtons and 18F-fluorodeoxyglucose uptake by brown adipose tissue in adults

The present study examines whether the daily rhythm of distal skin temperature (DST) is associated with brown adipose tissue (BAT) metabolism as determined by 18F-fluorodeoxyglucose (18F-FDG) uptake in young adults. Using a wireless thermometer (iButton) worn on the nondominant wrist, DST was measured in 77 subjects (26% male; age 22 ± 2 years; body mass index 25.2 ± 4.8 kg/m2) for 7 consecutive days. The temperatures to which they were habitually exposed over the day were also recorded. The interday stability of DST was calculated from the collected data, along with the intraday variability and relative amplitude; the mean temperature of the 5 and 10 consecutive hours with the maximum and minimum DST values, respectively; and when these hours occurred. Following exposure to cold, BAT volume and mean and peak standardized 18F-FDG uptake (SUVmean and SUVpeak) were determined for each subject via static 18F-FDG positron emission tomography/computed tomography scanning. Relative amplitude and the time at which the 10 consecutive hours of minimum DST values occurred were positively associated with BAT volume, SUVmean, and SUVpeak ( p ≤ 0.02), whereas the mean DST of that period was inversely associated with the latter BAT variables ( p ≤ 0.01). The interday stability and intraday variability of the DST were also associated (directly and inversely, respectively) with BAT SUVpeak ( p ≤ 0.02 for both). All of these associations disappeared, however, when the analyses were adjusted for the ambient temperature to which the subjects were habitually exposed. Thus, the relationship between the daily rhythm of DST and BAT activity estimated by 18F-FDG uptake is masked by environmental and likely behavioral factors. Of note is that those participants exposed to the lowest ambient temperature showed 3 to 5 times more BAT volume and activity compared with subjects who were exposed to a warmer ambient temperature.

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Distinct Uptake of 18F-Fluorodeoxyglucose by Brown Adipose Tissue with a Catecholamine-Secreting Tumor

Internal Medicine ◽

10.2169/internalmedicine.49.4293 ◽

2010 ◽

Vol 49 (21) ◽

pp. 2363-2363 ◽

Cited By ~ 4

Author(s):

Naoko Sekizawa ◽

Takanobu Yoshimoto ◽

Hajime Izumiyama ◽

Yukio Hirata

Keyword(s):

Adipose Tissue ◽

Brown Adipose Tissue ◽

18F Fluorodeoxyglucose ◽

Brown Adipose

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Periaortic Brown Adipose Tissue as a Major Determinant of [18F]-Fluorodeoxyglucose Vascular Uptake in Atherosclerosis-Prone, ApoE−/− Mice

PLoS ONE ◽

10.1371/journal.pone.0099441 ◽

2014 ◽

Vol 9 (7) ◽

pp. e99441 ◽

Cited By ~ 7

Author(s):

Jakub Toczek ◽

Alexis Broisat ◽

Pascale Perret ◽

Marie-Dominique Desruet ◽

Daniel Fagret ◽

...

Keyword(s):

Adipose Tissue ◽

Brown Adipose Tissue ◽

Major Determinant ◽

18F Fluorodeoxyglucose ◽

Brown Adipose

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Ephedrine-Induced Thermogenesis in Man: No Role for Interscapular Brown Adipose Tissue

Clinical Science ◽

10.1042/cs0660179 ◽

1984 ◽

Vol 66 (2) ◽

pp. 179-186 ◽

Cited By ~ 67

Author(s):

A. Astrup ◽

J. Bülow ◽

N. J. Christensen ◽

J. Madsen

Keyword(s):

Blood Flow ◽

Adipose Tissue ◽

Brown Adipose Tissue ◽

Skin Temperature ◽

Control Level ◽

Tissue Blood Flow ◽

Interscapular Brown Adipose Tissue ◽

Brown Adipose ◽

Adipose Tissue Blood Flow ◽

Lumbar Area

1. The warmest interscapular skin areas were located by thermography in six healthy subjects during ephedrine-induced thermogenesis. 2. In these interscapular areas, and in lumbar control areas, the skin temperature, subcutaneous temperature and adipose tissue blood flow were measured before and during ephedrine-induced thermogenesis. 3. The skin and subcutaneous temperatures increased in the interscapular area as well as in the lumbar area, by about 0.7-1.2°C. The interscapular skin temperature remained about 1°C higher than the lumbar; the subcutaneous temperatures in the two areas were identical during the experiments. 4. Although the interscapular subcutaneous adipose tissue blood flow increased about sixfold and the lumbar increased twofold, the absolute flows were higher in the lumbar area. 5. The oxygen uptake increased to a maximum of 30% above control level. 6. Plasma glucose and glycerol concentrations remained unchanged, and plasma non-esterified fatty acids, lactate and noradrenaline concentrations increased slightly but significantly. 7. Biopsies taken from the hot interscapular areas did not contain brown adipose tissue. 8. It is concluded that the high interscapular skin temperature may be due to a lower insulating fat thickness and that the increases in skin and subcutaneous temperatures during ephedrine-induced thermogenesis are caused by an increased blood flow. These observations weigh against the hypothesis that the interscapular temperature increase is due to functional, interscapular brown adipose tissue.

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