Concurrent validity of supraclavicular skin temperature measured with iButtons and infrared thermography as a surrogate marker of brown adipose tissue

Brown adipose tissue (BAT) activation is a possible therapeutic strategy to increase energy expenditure and improve metabolic homeostasis in obesity. Recent studies have revealed novel interactions between BAT and circulating lipid species—in particular, the non-esterified fatty acid (NEFA) and oxylipin lipid classes. This study aimed to identify individual lipid species that may be associated with cold-stimulated BAT activity in humans. A panel of 44 NEFA and 41 oxylipin species were measured using mass-spectrometry-based lipidomics in the plasma of fourteen healthy male participants before and after 90 min of mild cold exposure. Lipid measures were correlated with BAT activity measured via 18F-fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT), along with norepinephrine (NE) concentration (a surrogate marker of sympathetic activity). The study identified a significant increase in total NEFA concentration following cold exposure that was positively associated with NE concentration change. Individually, 33 NEFA and 11 oxylipin species increased significantly in response to cold exposure. The concentration of the omega-3 NEFA, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) at baseline was significantly associated with BAT activity, and the cold-induced change in 18 NEFA species was significantly associated with BAT activity. No significant associations were identified between BAT activity and oxylipins.

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Multimodal Imaging for the Detection of Brown Adipose Tissue Activation in Women: A Pilot Study Using NIRS and Infrared Thermography

Journal of Healthcare Engineering ◽

10.1155/2017/5986452 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 9

Author(s):

Valentina Hartwig ◽

Letizia Guiducci ◽

Martina Marinelli ◽

Laura Pistoia ◽

Tommaso Minutoli Tegrimi ◽

...

Keyword(s):

Adipose Tissue ◽

Pilot Study ◽

Brown Adipose Tissue ◽

Infrared Thermography ◽

Pharmacological Intervention ◽

Oral Glucose ◽

Cold Stimulation ◽

Standard Clinical Practice ◽

Obesity And Diabetes ◽

Brown Adipose

Purpose. A clear link between obesity and brown adipose tissue (BAT) dysfunction has been recently demonstrated. The purpose of this pilot study is to determine if near-infrared spectroscopy (NIRS) 2D imaging together with infrared thermography (IRT) is capable of identifying thermal and vascular response in the supraclavicular (SCV) areas after the ingestion of an oral glucose load as a thermogenic stimulation. Method. We studied two groups of women (obese versus lean) for discerning their different responses. NIRS and IRT images were acquired on the neck in the left SCV region during a 3 h oral glucose tolerance test (OGTT) and immediately after a cold stimulation. Results. We detected a significant thermal response of BAT in SCV fossa in both groups. Both during OGTT and after cold stimulation, skin temperature was persistently higher in lean versus obese. This response was not coupled with changes in oxygen saturation of subcutaneous tissue in that area. Discussion and Conclusion. The results show that NIRS/IRT may be a novel, noninvasive, radiation-free, easy to use, and low-cost method for monitoring, during the standard clinical practice, the diet and pharmacological intervention which aims to stimulate BAT as a potential therapeutic target against obesity and diabetes.

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Infrared thermography in the detection of brown adipose tissue in humans

Physiological Reports ◽

10.14814/phy2.12167 ◽

2014 ◽

Vol 2 (11) ◽

pp. e12167 ◽

Cited By ~ 46

Author(s):

Christina Jang ◽

Sandya Jalapu ◽

Moe Thuzar ◽

Phillip W Law ◽

Susanne Jeavons ◽

...

Keyword(s):

Adipose Tissue ◽

Brown Adipose Tissue ◽

Infrared Thermography ◽

Brown Adipose

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Thermal Imaging to Assess Age-Related Changes of Skin Temperature within the Supraclavicular Region Co-Locating with Brown Adipose Tissue in Healthy Children

The Journal of Pediatrics ◽

10.1016/j.jpeds.2012.04.056 ◽

2012 ◽

Vol 161 (5) ◽

pp. 892-898 ◽

Cited By ~ 103

Author(s):

Michael E. Symonds ◽

Katrina Henderson ◽

Lindsay Elvidge ◽

Conrad Bosman ◽

Don Sharkey ◽

...

Keyword(s):

Adipose Tissue ◽

Brown Adipose Tissue ◽

Skin Temperature ◽

Thermal Imaging ◽

Healthy Children ◽

Age Related ◽

Brown Adipose ◽

Age Related Changes

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Relationship between the Daily Rhythm of Distal Skin Temperature and Brown Adipose Tissue 18F-FDG Uptake in Young Sedentary Adults

Journal of Biological Rhythms ◽

10.1177/0748730419865400 ◽

2019 ◽

Vol 34 (5) ◽

pp. 533-550 ◽

Cited By ~ 2

Author(s):

Francisco M. Acosta ◽

Borja Martinez-Tellez ◽

Denis P. Blondin ◽

François Haman ◽

Patrick C. N. Rensen ◽

...

Keyword(s):

Adipose Tissue ◽

Ambient Temperature ◽

Brown Adipose Tissue ◽

Skin Temperature ◽

Daily Rhythm ◽

Relative Amplitude ◽

Fdg Uptake ◽

Brown Adipose ◽

The Mean ◽

Intraday Variability

The present study examines whether the daily rhythm of distal skin temperature (DST) is associated with brown adipose tissue (BAT) metabolism as determined by 18F-fluorodeoxyglucose (18F-FDG) uptake in young adults. Using a wireless thermometer (iButton) worn on the nondominant wrist, DST was measured in 77 subjects (26% male; age 22 ± 2 years; body mass index 25.2 ± 4.8 kg/m2) for 7 consecutive days. The temperatures to which they were habitually exposed over the day were also recorded. The interday stability of DST was calculated from the collected data, along with the intraday variability and relative amplitude; the mean temperature of the 5 and 10 consecutive hours with the maximum and minimum DST values, respectively; and when these hours occurred. Following exposure to cold, BAT volume and mean and peak standardized 18F-FDG uptake (SUVmean and SUVpeak) were determined for each subject via static 18F-FDG positron emission tomography/computed tomography scanning. Relative amplitude and the time at which the 10 consecutive hours of minimum DST values occurred were positively associated with BAT volume, SUVmean, and SUVpeak ( p ≤ 0.02), whereas the mean DST of that period was inversely associated with the latter BAT variables ( p ≤ 0.01). The interday stability and intraday variability of the DST were also associated (directly and inversely, respectively) with BAT SUVpeak ( p ≤ 0.02 for both). All of these associations disappeared, however, when the analyses were adjusted for the ambient temperature to which the subjects were habitually exposed. Thus, the relationship between the daily rhythm of DST and BAT activity estimated by 18F-FDG uptake is masked by environmental and likely behavioral factors. Of note is that those participants exposed to the lowest ambient temperature showed 3 to 5 times more BAT volume and activity compared with subjects who were exposed to a warmer ambient temperature.

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