FRI-18 THE HISTORY OF BCG AND BLADDER CANCER: ETHICAL CONCERNS FROM UROLOGY’S RECENT PAST

Textualizing the memory(ies) of physical and cultural encounter(s) between Self and Other, travel literature/writing often combines subjectivity with documental information which may prove relevant to better assess mentalities, everyday life and the social history of any given ‘timeplace’. That is the case with Growing up English. Memories of Portugal 1907-1930, by D. J. Baylis (née Bucknall), prefaced by Peter Mollet as “(…) a remarkably vivid and well written observation of the times expressed with humour and not little ‘carinho’. In all they make excellent reading especially for those of us interested in the recent past.” (Baylis: 2)

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Association of combined phase I/II study of a novel bicyclic peptide and MMAE conjugate BT8009 in patients with advanced malignancies with Nectin-4 expression.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.tps2668 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. TPS2668-TPS2668

Author(s):

Meredith McKean ◽

Gerald Steven Falchook ◽

Johanna C. Bendell ◽

Babar Bashir ◽

Neil Palmisiano ◽

...

Keyword(s):

Bladder Cancer ◽

Single Agent ◽

Pancreatic Head ◽

Uncontrolled Hypertension ◽

Clinical Activity ◽

Highly Active ◽

History Of ◽

Cyp3a4 Inhibitors ◽

Critical Organ ◽

Peptide Targeting

TPS2668 Background: BT8009 is a Bicycle Toxin Conjugate (BTC), a novel class of chemically synthesized molecules, comprising a bicyclic peptide targeting Nectin-4 tumor antigen, linked to cytotoxin (monomethyl auristatin E [MMAE]) via a valine-citrulline (val-cit) cleavable linker. Nectins (Nectin-1, -2, -3, and -4) and nectin-like molecules (Necl) are Ca2+ independent immunoglobulin-like cell adhesion molecules. Recent studies have shown the importance of Nectin-4 in several human cancers, including lung, ovarian, breast and bladder cancer; however, the precise roles and clinical relevance of Nectin-4 in tumors remain largely unknown. The Nectin-4 targeted enfortumab vedotin, linked to MMAE via a val-cit linker, is highly active in late-stage bladder cancer and demonstrates notable additional clinical activity as a single agent and in combination with pembrolizumab1. Skin toxicities, bone marrow suppression, peripheral neuropathy and diabetes have been associated with enfortumab, with some of these toxicities already noted with MMAE-bearing antibody therapies. We anticipate a similar toxicity profile for BT8009 in clinical studies. BT8009 exhibited a favorable preclinical profile and was effective in a range of cell-derived xenograph tumor models. Methods: Study BT8009-100 (NCT04561362) will evaluate safety and tolerability of weekly and every other week BT8009 administration, alone and in combination with q4w nivolumab. Determination of both a realistic phase 2 dose and a sequence will also be key to further exploration of safety and efficacy signals, along with an early examination of the role of baseline immunohistochemistry-ascertained levels of tumor Nectin-4. Patients will be recruited with advanced solid tumors associated with Nectin-4 expression after exhausting SOC options (i.e., bladder, breast, pancreatic, head and neck, gastric, esophageal and ovarian). Patients must have available tumor tissue, acceptable hematologic and other critical organ function and be willing to participate. Appropriate ethical and regulatory approvals and advice will be in place and adhered to. Exclusion criteria include uncontrolled brain metastases, uncontrolled hypertension, concomitant CYP3A4 inhibitors and significant history of autoimmune disease for the nivolumab cohorts. PK serial collections will be taken on D1 through D15. Radiologic tumor assessments for response per RECIST will be taken every two months. 1. Enfortumab Vedotin. FDA_data. 761137Orig1s000MultiDiscliplineR.pdf (fda.gov). Clinical trial information: NCT04561362.

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THE RUSSIAN OUTPOST OF PURE SCIENCE IN THE GLOBAL OCEAN (TO THE 75-TH ANNIVERSARY OF SIO RAS, 1946–2021)

Journal of Oceanological Research ◽

10.29006/1564-2291.jor-2021.49(3).2 ◽

2021 ◽

Vol 49 (3) ◽

pp. 12-32

Keyword(s):

Research Team ◽

General Information ◽

Global Ocean ◽

Recent Past ◽

Historical Events ◽

Pure Science ◽

History Of ◽

Entire History ◽

Academy Of Sciences ◽

Large Research

A brief overview of the main historical events that accompanied the formation and establishment of the Laboratory of Oceanology in the Academy of Sciences in 1941 is given. Then, a few years later, the Laboratory was transformed into the Institute of Oceanology, the director of which was appointed the Minister of the Merchant Fleet of the USSR, Academician P. P. Shirshov. By his initiative in 1949, the Institute became the owner of its first large research vessel "Vityaz". It is shown that the entire history of the institute and its research team was primarily based on the development and generalization of the results of regular sea and ocean expeditions. The article provides general information about the results obtained in the recent past, and their development and deepening in the works of the institute at present.

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The tompon-tany and the tompon-drano in the History of Central and Western Madagascar

History in Africa ◽

10.2307/3171599 ◽

1982 ◽

Vol 9 ◽

pp. 61-76

Author(s):

Finn Fuglestad

Keyword(s):

Seventeenth Century ◽

West Coast ◽

Religious Beliefs ◽

Eastern Coast ◽

Recent Past ◽

The West ◽

Political Consequences ◽

The People ◽

History Of ◽

Conceptual Revolution

At some undefined time in the fairly recent past central and western Madagascar witnessed a conceptual 'revolution' which had far-reaching political consequences. The religious beliefs and symbols which constituted the main ingredients of this 'revolution'--and probably also the people who propagated them--were in some way connected with the Zafindraminia-Antanosy and the Anteimoro of the southeastern and eastern coast. It is quite clear that these and similar groups had been strongly influenced by Islam and that they practiced what could perhaps be described as a corrupt or diluted Islam or a syncretic 'pagan' Muslim religion. (It is significant that as their name indicates the Zafindraminia claim descent from Raminia who they hold to have been the mother of Muhammad.) One of the main ingredients of this religion was the cult of the ody or guardian amulets, objects usually made of wood which are strikingly reminiscent of the so-called “charms” or “gris-gris” sold by Muslim clerics over much of Africa. Another ingredient is represented by the institution of ombiasy. The ombiasy (the main manufacturers of ody) whom the Frenchman Etienne de Flacourt at Fort-Dauphin in the seventeenth century took to be Muslim clerics were originally the “priests” (or the “devins guérisseurs,” according to Hubert Deschamps) of the Anteimoro and the Zafindraminia-Antanosy. Subsequently this institution was disseminated throughout nearly the whole of Madagascar. Yet another ingredient was the system of divination known as sikidy, which also spread to other parts of Madagascar, including Imerina and the Sakalava country.These beliefs, symbols, and institutions deeply influenced the people of the west coast (the present-day Sakalava country) and of central Madagascar (Imerina and Betsileo country).

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THE NATURAL HISTORY OF BLADDER CANCER

Urologic Clinics of North America ◽

10.1016/s0094-0143(05)70229-9 ◽

2000 ◽

Vol 27 (1) ◽

pp. 1-13 ◽

Cited By ~ 117

Author(s):

Richard Lee ◽

Michael J. Droller

Keyword(s):

Bladder Cancer ◽

Natural History ◽

History Of

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Kulturwissenschaft in der Ermüdung? Anmerkungen zu einer Neuorientierung

Kulturwissenschaftliche Zeitschrift ◽

10.1515/kwg-2016-0006 ◽

2016 ◽

Vol 1 (1) ◽

pp. 49-55

Author(s):

Doris Bachmann-Medick

Keyword(s):

Research Process ◽

History Of Ideas ◽

Self Reflection ◽

Ethical Concerns ◽

History Of ◽

Translational Approach

Abstract Starting from the conviction that the study of culture(s) is much broader than a philosophizing history of ideas approach (one that often retains implicit Eurocentric assumptions), this article is a plea for a reorientation of the study of culture through the demonstration of a stronger commitment to a sociological, empirical and transcultural approach in the study of culture. Instead of focusing on cultural syntheses (i.e. along the main signatures and „Zeitgeist“ symptoms of epochs), my argument redirects attention to particularities, hidden dimensions, and the formation of differences, to cultural countermovements and contradictions. The article suggests a more complex and action-oriented „translational“ approach. It aims to foster a critical self-reflection of the research process of the study of culture itself with regard to its analytical concepts, its societal and ethical concerns, and its fruitful convergence of disciplines.

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The cycle of the new left in the recent history of Argentina

Latin-american Historical Almanac ◽

10.32608/2305-8773-2021-31-1-252-279 ◽

2021 ◽

Vol 31 (1) ◽

pp. 252-279

Author(s):

Maria Cristina Tortti ◽

Keyword(s):

Social Order ◽

New Left ◽

Social Protest ◽

Political Regime ◽

The Political ◽

Recent Past ◽

The Social ◽

Wide Range ◽

History Of ◽

Multiple Actors

This paper aims at outlining the main processes that, in Argentina’s recent past, may enable us to understand the emergence, development and eventual defeat of the social protest movement and the political radicalization of the period 1960-70s.Here, as in previous papers, we resort to the concept of new left toname the movement that, though heterogeneous and lacking a unified direction, became a major unit in deeds, for multiple actors coming the most diverse angles coincided in opposing the vicious political regime and the social order it supported. Consequently, we shall try to reinstate the presence of such wide range of actors: their projects, objectives and speeches. Some critical circumstances shall be detailed and processes through which protests gradually amalgamated will be shown. Such extended politicization provided the frame for quite radical moves ranging from contracultural initiatives and the classism in the workers’ movement to the actual action of guerrilla groups. Through the dynamics of the events themselves we shall locate the peak moments as well as those which paved the way for their closure and eventual defeat in 1976.

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The politic history of early Stuart parliaments

Writing the history of parliament in Tudor and early Stuart England ◽

10.7228/manchester/9780719099588.003.0008 ◽

2018 ◽

pp. 172-193

Author(s):

Noah Millstone

Keyword(s):

Seventeenth Century ◽

Recent Past ◽

Divine Intervention ◽

Institutional Settings ◽

Human Intentionality ◽

History Of ◽

Late Renaissance ◽

Church Councils

This essay traces the development of a particular way of writing the history of parliament: the politic history. A creation of the late Renaissance, politic histories preferred to explain events neither through divine intervention, nor through imperceptible forces and contingency, but rather through human intentionality. Following classical and contemporary models such as Tacitus, Commynes and Guicciardini, English politic historians wove narratives of vice, secrecy and dissimulation. The essay explores how, in the early seventeenth century, historians appropriated the modes of politic composition and applied them to new institutional settings: university elections, church councils and especially parliaments. It concludes with an analysis of the most impressive politic history of the early Stuart parliament, Sir John Eliot’s Negotium posterorum. Composed during Eliot’s imprisonment after 1629, the Negotium posterorurm is clearly the first part of a formal, politic history of Charles I’s reign, heavily modelled on Tacitus and with parliament as its central stage. Eliot’s project suggests how politic narration could be applied to the recent past, helping to produce historicised accounts of the present.

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