scholarly journals Public Health and Economic Impact of Vaccinating Children with a Quadrivalent live Attenuated Influenza Vaccine in France Using a Dynamic Transmission Model

2014 ◽  
Vol 17 (7) ◽  
pp. A674 ◽  
Author(s):  
L. Gerlier ◽  
C. Weil-Olivier ◽  
F. Carrat ◽  
X. Lenne ◽  
M. Lamotte ◽  
...  
Keyword(s):  
Public Health ◽  
Influenza Vaccine ◽  
Economic Impact ◽  
Transmission Model ◽  
Live Attenuated Influenza Vaccine ◽  
Dynamic Transmission Model

scholarly journals The epidemiological and economic impact of a cell-based quadrivalent influenza vaccine in an adult population in the US: a dynamic modeling approach

2020 ◽  
Author(s):  
Van Hung Nguyen ◽  
Yvonne Hilsky ◽  
Joaquin Mould-Quevedo
Keyword(s):  
Public Health ◽  
Cost Saving ◽  
Influenza Vaccine ◽  
Economic Impact ◽  
Adult Population ◽  
Vaccine Effectiveness ◽  
Transmission Model ◽  
Life Years ◽  
A Cell ◽  
Quadrivalent Influenza Vaccine

Abstract BackgroundMutations of the H3N2 vaccine strain during the egg-based vaccine manufacturing process seem to partly explain the suboptimal effectiveness of traditional seasonal influenza vaccine. Cell-based influenza vaccines avoid such egg-adaptation, thereby improving antigenic match and vaccine effectiveness. The objective of this study was to evaluate the public health and economic impact of a cell-based quadrivalent influenza vaccine (QIVc) in adult population (18–64 years) compared to the standard egg-based quadrivalent influenza vaccine (QIVe), in the US.MethodsThe impact of QIVc over QIVe in terms of public health and costs outcomes was estimated using a dynamic SEIR transmission model. The model is age-structured and accounts for 4 circulating influenza strains (A/H1N1pdm9, A/H3N2, B(Victoria), and B(Yamagata)). It was calibrated on US attack rate and strain circulation for the seasons 2013–2018. US specific absolute vaccine effectiveness for QIVe, specific hospitalization rate, mortality rate, Quality-Adjusted Life Years (QALYs) and costs were extracted from published literature. Relative vaccine effectiveness of QIVc over QIVe for subjects 18–64 years of age was obtained from a US retrospective cohort study. Robustness of the results was assessed in univariate and probabilistic sensitivity analyses.ResultsSwitching from QIVe to QIVc in the 18–64 year-old population may prevent 5.7 M symptomatic cases, 1.8 M outpatient visits; 50K hospitalizations and 5,453 deaths annually. The switch could save 128 K QALYs and US$ 845M in direct costs, resulting in a cost-saving alternative in a 3-year time horizon analysis. Probabilistic sensitivity analyses confirmed the robustness of the cost-saving result.ConclusionsThe analysis shows that QIVc is expected to prevent a substantial number of hospitalizations and deaths, and would result in substantial savings in health care costs.

scholarly journals Public health and economic impact of switching from a trivalent to a quadrivalent inactivated influenza vaccine in Mexico

2019 ◽  
Vol 16 (4) ◽  
pp. 827-835
Author(s):  
Guillermo M. Ruiz-Palacios ◽  
John H. Beigel ◽  
Maria Lourdes Guerrero ◽  
Lucile Bellier ◽  
Ramiro Tamayo ◽  
...  
Keyword(s):  
Public Health ◽  
Influenza Vaccine ◽  
Economic Impact

scholarly journals The Epidemiological and Economic Impact of a Cell-Based Quadrivalent Influenza Vaccine in Adults in the US: A Dynamic Modeling Approach

Vaccines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1095
Author(s):  
Van Hung Nguyen ◽  
Yvonne Hilsky ◽  
Joaquin Mould-Quevedo
Keyword(s):  
Public Health ◽  
Influenza Vaccine ◽  
Economic Impact ◽  
Influenza Vaccines ◽  
Sensitivity Analyses ◽  
Life Years ◽  
The Us ◽  
A Cell ◽  
The Impact ◽  
Quadrivalent Influenza Vaccine

Mutations of the H3N2 vaccine strain during the egg-based vaccine manufacturing process partly explain the suboptimal effectiveness of traditional seasonal influenza vaccines. Cell-based influenza vaccines improve antigenic match and vaccine effectiveness by avoiding such egg-adaptation. This study evaluated the public health and economic impact of a cell-based quadrivalent influenza vaccine (QIVc) in adults (18–64 years) compared to the standard egg-based quadrivalent influenza vaccine (QIVe) in the US. The impact of QIVc over QIVe in public health and cost outcomes was estimated using a dynamic age-structured SEIR transmission model, which accounted for four circulating influenza strains [A/H1N1pdm9, A/H3N2, B(Victoria), and B(Yamagata)] and was calibrated on the 2013–2018 influenza seasons. The robustness of the results was assessed in univariate and probabilistic sensitivity analyses. Switching from QIVe to QIVc in 18- to 64-year-olds may prevent 5.7 million symptomatic cases, 1.8 million outpatient visits, 50,000 hospitalizations, and 5453 deaths annually. The switch could save 128,000 Quality-Adjusted Life Years (QALYs) and US $ 845 M in direct costs, resulting in cost-savings in a three-year time horizon analysis. Probabilistic sensitivity analyses confirmed the robustness of the cost-saving result. The analysis shows that QIVc is expected to prevent hospitalizations and deaths, and result in substantial savings in healthcare costs.

scholarly journals Evaluation of Economic Impact of tuberculosis control In Malaysia Using Dynamic Transmission Model

2015 ◽  
Vol 18 (3) ◽  
pp. A244
Author(s):  
W.H. Fun ◽  
D.B. Wu ◽  
Y.M. Cheong ◽  
N. Mohamad Noordin ◽  
K.K. Lee
Keyword(s):  
Economic Impact ◽  
Transmission Model ◽  
Tuberculosis Control ◽  
Dynamic Transmission Model

scholarly journals Cost-Utility of Quadrivalent Versus Trivalent Influenza Vaccine in Germany, Using an Individual-Based Dynamic Transmission Model

2016 ◽  
Vol 34 (12) ◽  
pp. 1299-1308 ◽  
Author(s):  
Christiaan Dolk ◽  
Martin Eichner ◽  
Robert Welte ◽  
Anastassia Anastassopoulou ◽  
Laure-Anne Van Bellinghen ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Cost Utility ◽  
Transmission Model ◽  
Trivalent Influenza Vaccine ◽  
Dynamic Transmission Model

scholarly journals MITIGATING THE 4th WAVE OF THE COVID-19 PANDEMIC IN ONTARIO

2021 ◽  
Author(s):  
Lauren E. Cipriano ◽  
Wael M. R. Haddara ◽  
Beate Sander
Keyword(s):  
Public Health ◽  
Critical Care ◽  
Vaccine Coverage ◽  
Grey Literature ◽  
Age Distribution ◽  
Current Level ◽  
Transmission Model ◽  
Health Measures ◽  
Dynamic Transmission Model ◽  
Care Capacity

Background: The goal of this study was to project the number of COVID-19 cases and demand for acute hospital resources for Fall of 2021 in a representative mid-sized community in southwestern Ontario. We sought to evaluate whether current levels of vaccine coverage and contact reduction could mitigate a potential 4th wave fueled by the Delta variant, or whether the reinstitution of more intense public health measures will be required. Methods: We developed an age-stratified dynamic transmission model of COVID-19 in a mid-sized city (population 500,000) currently experiencing a relatively low, but increasing, infection rate in Step 3 of Ontario's Wave 3 recovery. We parameterized the model using the medical literature, grey literature, and government reports. We estimated the current level of contact reduction by model calibration to cases and hospitalizations. We projected the number of infections, number of hospitalizations, and the time to re-instate high intensity public health measures over the fall of 2021 under different levels of vaccine coverage and contact reduction. Results: Maintaining contact reductions at the current level, estimated to be a 17% reduction compared to pre-pandemic contact levels, results in COVID-related admissions exceeding 20% of pre-pandemic critical care capacity by late October, leading to cancellation of elective surgeries and other non-COVID health services. At high levels of vaccination and relatively high levels of mask wearing, a moderate additional effort to reduce contacts (30% reduction compared to pre-pandemic contact levels), is necessary to avoid re-instating intensive public health measures. Compared to prior waves, the age distribution of both cases and hospitalizations shifts younger and the estimated number of pediatric critical care hospitalizations may substantially exceed 20% of capacity. Discussion: High rates of vaccination coverage in people over the age of 12 and mask wearing in public settings will not be sufficient to prevent an overwhelming resurgence of COVID-19 in the Fall of 2021. Our analysis indicates that immediate moderate public health measures can prevent the necessity for more intense and disruptive measures later.

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