Cytogenetics And Dopamine Receptor (Drd2) Gene Polymorphism In Schizophrenia Patients

Recent studies have shown that incessant job stress could eventually result in sleep dysfunction (SD), and most importantly, the essential role dopamine receptor D2 (DRD2) gene polymorphisms play in the psychopathological mechanism of SD. The Effort-Reward Imbalance scale and the Pittsburgh Sleep Quality Index were both used to access SD and job stress (JS). A significant negative correlation was observed between the sDA levels and SD subscale scores (sleep efficiency, daytime dysfunction). The findings revealed that high levels of JS were linked to a higher SD score (OR = 2.13, 95% CI: 1.46–3.12). Likewise, the homozygous A1A1 genotype of DRD2 rs1800497 was more likely to be associated with SD (OR = 2.90, 95% CI: 1.75–4.82). Compared to participants with low JS and heterozygous A1A2/A2A2 genotype, those with both high JS and homozygous A1A1 genotype had a higher SD score (OR = 5.40, 95% CI: 2.89–10.11). The A1 allele of the DRD2 rs1800497 polymorphism also enhances the likelihood of SD when undergoing JS. Besides, subjects with low JS and the homozygous A1A1 genotype also showed an increased possibility for sleep dysfunction (OR = 2.05, 95% CI: 1.03–4.11). Our results suggest that the DA system may interrelate with JS to affect sleep.

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D2 dopamine receptor (DRD2) gene Taq1A polymorphism and the eatingrelated psychological traits in eating disorders (anorexia nervosa and bulimia) and obesity

Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity ◽

10.1007/bf03327583 ◽

2007 ◽

Vol 12 (2) ◽

pp. 91-96 ◽

Cited By ~ 46

Author(s):

E. Nisoli ◽

A. Brunani ◽

E. Borgomainerio ◽

C. Tonello ◽

L. Dioni ◽

...

Keyword(s):

Eating Disorders ◽

Anorexia Nervosa ◽

Dopamine Receptor ◽

D2 Dopamine Receptor ◽

Drd2 Gene ◽

Psychological Traits

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D2 dopamine receptor (DRD2) polymorphism is associated with severity of alcohol dependence

European Psychiatry ◽

10.1016/s0924-9338(02)00625-9 ◽

2002 ◽

Vol 17 (1) ◽

pp. 17-23 ◽

Cited By ~ 58

Author(s):

J.P. Connor ◽

R.McD. Young ◽

B.R. Lawford ◽

T.L. Ritchie ◽

E.P. Noble

Keyword(s):

Alcohol Dependence ◽

Dopamine Receptor ◽

Problem Drinking ◽

Drinking Behavior ◽

D2 Dopamine Receptor ◽

Drd2 Gene ◽

Allele Status ◽

Alcohol Detoxification ◽

Dependence Scale ◽

Alcohol Dependent

SummaryThe A1 allele of the D2 dopamine receptor (DRD2) gene has been associated with alcohol dependence. However, the expression of this allele risk on the severity of drinking behavior in patients with alcohol dependence has not been systematically explored. The present study examines the association between DRD2 A1+(A1/A1 and A1/A2 genotypes) and A1– (A2/A2 genotype) allele status and key drinking parameters in alcohol-dependent patients. A sample of Caucasian adults was recruited from an alcohol detoxification unit. A clinical interview and the Alcohol Dependence Scale (ADS) questionnaire provided data on consumption, dependence, chronology of drinking and prior detoxification. A1+ allele compared to A1– allele patients consumed higher quantities of alcohol, commenced problem drinking at an earlier age, experienced a shorter latency between first introduction to alcohol to the onset of problem drinking and had higher ADS scores. Moreover, A1+ allele patients had more detoxification attempts than their A1– allele counterparts. In sum, alcohol-dependent patients with the DRD2 A1 allele compared to patients without this allele are characterized by greater severity of their disorder across a range of problem drinking indices. The implications of these findings are discussed.

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