PIN10 ESTIMATING THE IMPACT OF A GENDER-NEUTRAL QUADRIVALENT HUMAN PAPILLOMAVIRUS VACCINATION PROGRAM IN ALL HPV6/11/16/18-RELATED DISEASES IN BRAZIL WITH A HIGHER VACCINE COVERAGE RATE

Background Human papillomavirus (HPV) vaccines and their widespread adoption have the potential to relieve a large part of the burden of cervical cancer morbidity and mortality, particularly in countries that have low screening rates or, like Japan, lack a cohesive universal screening program. An economic evaluation was conducted to assess the cost-effectiveness of introducing a bivalent HPV vaccination program in Japan from a healthcare perspective. Methods: A Markov model of the natural history of HPV infection that incorporates both vaccination and screening was developed for Japan. The modelled intervention, a bivalent HPV vaccine with a 100% lifetime vaccine efficacy and 80% vaccine coverage, given to a cohort of 12-year-old Japanese girls in conjunction with the current screening program, was compared with screening alone in terms of costs and effectiveness. A discount rate of 5% was applied to both costs and utilities where relevant. Results: Vaccination alongside screening compared with screening alone is associated with an incremental cost-effectiveness ratio (ICER) of US$20 315 per quality-adjusted-life-year gained if 80% coverage is assumed. The ICER at 5% coverage with the vaccine plus screening, compared with screening alone, is US$1158. Conclusion: The cost-effectiveness results suggest that the addition of a HPV vaccination program to Japan’s cervical cancer screening program is highly likely to prove a cost-effective way to reduce the burden of cervical cancer, precancerous lesions and HPV16/18-related diseases.

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Cost-effectiveness analysis of a gender-neutral human papillomavirus vaccination program in the Netherlands

Vaccine ◽

10.1016/j.vaccine.2020.05.031 ◽

2020 ◽

Vol 38 (30) ◽

pp. 4687-4694 ◽

Cited By ~ 1

Author(s):

Joost J.M. Simons ◽

Nora Vida ◽

Tjalke A. Westra ◽

Maarten J. Postma

Keyword(s):

Human Papillomavirus ◽

Cost Effectiveness ◽

The Netherlands ◽

Cost Effectiveness Analysis ◽

Vaccination Program ◽

Human Papillomavirus Vaccination ◽

Effectiveness Analysis ◽

Gender Neutral

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Opportunities to increase rates of human papillomavirus vaccination in the New South Wales school program through enhanced catch-up

Sexual Health ◽

10.1071/sh15132 ◽

2016 ◽

Vol 13 (6) ◽

pp. 536 ◽

Cited By ~ 5

Author(s):

Christine Staples ◽

Michelle Butler ◽

Jennifer Nguyen ◽

David N. Durrheim ◽

Patrick Cashman ◽

...

Keyword(s):

High School Students ◽

Human Papillomavirus ◽

Hpv Vaccine ◽

Vaccine Coverage ◽

Hpv Vaccination ◽

Vaccination Program ◽

Completion Rates ◽

School Program ◽

Human Papillomavirus Vaccination ◽

Catch Up

Background The National Human Papillomavirus (HPV) Vaccination Program provides HPV vaccine to high school students through school-based vaccination. We aimed to: 1) assess the vaccine completion rates achieved when general practice is used for completing doses missed at school; 2) estimate the extent of under-notification by general practices of vaccine doses administered; and 3) assess the reasons reported by parents of students for non-completion of HPV vaccination. Methods: A postal survey was conducted of parents and carers of students and identified, using school-program records, as incompletely vaccinated in a large regional area of northern NSW vaccinated during 2010. Information about additional HPV vaccine doses received or reasons for non-completion were sought. Responses were analysed and records cross-checked against the National HPV Vaccination Program Register. Results: Of 660 parents or carers contacted, 207 (31.4%) responded. We found: 1) completion rates increased, an additional 122/207 (45.2%) students had completed all three doses of HPV through their general practitioner (GP); 2) under-notification of GP doses to the National HPV Vaccination Program Register was an issue with only 5/165 (3.0%) reported; 3) the main reason for non-completion was being unaware of the opportunity to catch-up at a GP. Conclusions: Underreporting by GPs of HPV vaccine doses administered and failure to complete courses identifies two opportunities to increase HPV vaccine coverage. These could be addressed by extending provision of catch-up HPV doses in school and by developing practice software solutions for automatic notification of doses from GPs. Reasons given by parents for non-completion, mostly logistical barriers, indicate a high degree of acceptance of HPV vaccination.

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Monitoring the control of human papillomavirus (HPV) infection and related diseases in Australia: towards a national HPV surveillance strategy

Sexual Health ◽

10.1071/sh09137 ◽

2010 ◽

Vol 7 (3) ◽

pp. 310 ◽

Cited By ~ 33

Author(s):

Julia M. L. Brotherton ◽

John M. Kaldor ◽

Suzanne M. Garland

Keyword(s):

Human Papillomavirus ◽

Vaccine Coverage ◽

Cervical Screening ◽

Hpv Vaccination ◽

Hpv Infection ◽

Vaccination Program ◽

Surveillance Strategy ◽

Pap Screening ◽

Incidence And Mortality ◽

The Impact

This paper describes a possible multifaceted approach to human papillomavirus (HPV) related surveillance in Australia following implementation of a national HPV vaccination program. We describe eight main components: monitoring of vaccine coverage, vaccine safety, type-specific HPV infection surveillance, cervical cytology (Pap screening) coverage and screen detected lesion prevalence, cervical cancer incidence and mortality, genital wart incidence, incidence of recurrent respiratory papillomatosis, and knowledge, attitudes and beliefs about HPV and HPV vaccination. Australia is well placed to monitor the impact of its HPV vaccination program as well as to measure vaccine effectiveness with existing HPV vaccines, cervical screening and cancer registries.

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Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM)

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18030963 ◽

2021 ◽

Vol 18 (3) ◽

pp. 963

Author(s):

Javier Díez-Domingo ◽

Víctor Sánchez-Alonso ◽

Rafael-J. Villanueva ◽

Luis Acedo ◽

José Tuells

Keyword(s):

Vaccine Coverage ◽

Hpv Vaccination ◽

Herd Immunity ◽

Hpv Infection ◽

Vaccination Program ◽

Force Of Infection ◽

Long Term Effect ◽

Gender Neutral ◽

Sex With Men ◽

The Impact

A major challenge in human papillomavirus (HPV) vaccine programs is the universal gender-neutral recommendation, as well as estimation of its long-term effect. The objective of this study is to predict the added benefit of male vaccination, especially in men who have sex with men (MSM), and to analyze the impact of the program on society. We propose a mathematical model of the HPV infection based on a network paradigm. Data from Spain allowed constructing the sexual network. HPV force of infection was taken from literature. Different scenarios using variable vaccine coverage in both males and females were studied. Strong herd immunity is shown in the heterosexual population, with an important decrease of HPV 6/11 infections both in men and in unvaccinated women with an only-women vaccination at 14 years of age. No impact of this program occurred in the infection incidence in MSM. This group would only benefit from a vaccination program that includes males. However, the impact at short term would be lower than in heterosexual men. The protection of MSM can only be achieved by direct vaccination of males. This may have important consequences for public health.

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Human papillomavirus vaccination: the population impact

F1000Research ◽

10.12688/f1000research.10691.1 ◽

2017 ◽

Vol 6 ◽

pp. 866 ◽

Cited By ~ 41

Author(s):

Lai-yang Lee ◽

Suzanne M. Garland

Keyword(s):

Human Papillomavirus ◽

Vaccine Coverage ◽

Cervical Screening ◽

Hpv Vaccination ◽

National Guidelines ◽

Human Papillomavirus Vaccination ◽

Vaccination Programs ◽

Screening Programs ◽

National Immunisation ◽

The Impact

We currently have the knowledge and experience to prevent much of human papillomavirus (HPV)-related disease burden globally. In many countries where prophylactic HPV vaccination programs have been adopted as highly effective public health programs with good vaccine coverage, we are already seeing, in real-world settings, reduction of vaccine-related HPV-type infections, genital warts and cervical pre-cancers with potential reductions in vulvar, vaginal and anal pre-cancers. Moreover, we are seeing a change in cervical screening paradigms, as HPV-based screening programs now have strong evidence to support their use as more sensitive ways to detect underlying cervical abnormalities, as compared with conventional cervical cytology. This article describes the impact of prophylactic vaccination on these outcomes and in settings where these vaccines have been implemented in national immunisation programs. Given the successes seen to date and the availability of essential tools, there has been a global push to ensure that every woman has access to effective cervical screening and every girl has the opportunity for primary prevention through vaccination. A gender-neutral approach by offering vaccination to young boys has also been adopted by some countries and is worthy of consideration given that HPV-related cancers also affect males. Furthermore, vaccination of young boys has the advantage of reducing the risk of HPV transmission to sexual partners, lowering the infectious pool of HPV in the general population and ultimately HPV-related diseases for both genders. Therefore, it is appropriate that all countries consider and promote national guidelines and programs to prevent HPV-related diseases.

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