Postmortem serum protein S100B levels with regard to the cause of death involving brain damage in medicolegal autopsy cases

2006 ◽  
Vol 8 (2) ◽  
pp. 71-77 ◽  
Author(s):  
Dong-Ri Li ◽  
Bao-Li Zhu ◽  
Takaki Ishikawa ◽  
Dong Zhao ◽  
Tomomi Michiue ◽  
...  
Keyword(s):  
Brain Damage ◽  
Cause Of Death ◽  
Serum Protein ◽  
Medicolegal Autopsy ◽  
Protein S100b

scholarly journals Persephin as a diagnostic marker of acute brain injury in critically ill newborns: a clinical trial

2021 ◽  
Vol 6 (3) ◽  
pp. 15-24
Author(s):  
A. A. Zadvornov ◽  
E. V. Grigoriev
Keyword(s):  
Brain Injury ◽  
Brain Damage ◽  
Critically Ill ◽  
Serum Protein ◽  
Cerebral Edema ◽  
Apgar Score ◽  
Prognostic Significance ◽  
Rank Correlation ◽  
Unfavorable Outcome ◽  
Protein S100b

Aim. To study the correlation of serum persephin with clinical, instrumental and biochemical indicators of brain damage and with an adverse outcome in critically ill newborns.Materials and Methods. The study included 44 critically ill newborns. Blood samples were collected on the 1st and 7th day of life. Brain injury was assessed by recording Apgar score, depression of consciousness and brainstem reflexes in unsedated patients over 7 days of life, convulsions, neurosonographic signs of cerebral edema, serum protein S100B on the 1st and 7th day of life, and using indicators of adverse neurological outcome. The correlation of serum persephin on the 1st and 7th day of life with signs of brain damage was evaluated using the Spearman's rank correlation coefficient and Mann-Whitney U-test.Results. No statistically significant correlation was found between the concentrations of serum persephin on the 1st and 7th day of life and Apgar score (p = 0.721 and 0.222, respectively), depression of consciousness and stem reflexes (p < 0.05), convulsions (p = 0.673 and 0.432, respectively), cerebral edema (p = 0.737 and 0.558, respectively), and serum protein S100B both on the 1st day (p = 0.095 and 0.475, respectively) and 7th day of life (p = 0.988 and p = 0.775, respectively). Further, there was no statistically significant association of the serum persephin on the 1st day of line with an unfavorable outcome (p = 0.294). Yet, we revealed an association of serum persephin on the 7th day of life with an unfavorable outcome (p = 0.013), with a cut-off point of 828 ng/mL, a sensitivity of 39%, and a specificity of 100%.Conclusion. Persephin has poor diagnostic and prognostic significance for assessing the severity of brain damage in critically ill newborns. The obtained data on the correlation of the concentration of persephin for 7 days with an unfavorable outcome are doubtful due to the lack of data on its correlation with signs of severe brain damage.

Postmortem serum levels of pulmonary surfactant-associated proteins A and D with regard to the cause of death in medicolegal autopsy

2009 ◽  
Vol 11 ◽  
pp. S301-S303 ◽  
Author(s):  
Li Quan ◽  
Bao-Li Zhu ◽  
Takaki Ishikawa ◽  
Tomomi Michiue ◽  
Dong Zhao ◽  
...  
Keyword(s):  
Cause Of Death ◽  
Pulmonary Surfactant ◽  
Serum Levels ◽  
Medicolegal Autopsy ◽  
Associated Proteins

Increased serum levels of the brain damage marker S100B after apnea in trained breath-hold divers: a study including respiratory and cardiovascular observations

2009 ◽  
Vol 107 (3) ◽  
pp. 809-815 ◽  
Author(s):  
Johan P. A. Andersson ◽  
Mats H. Linér ◽  
Henrik Jönsson
Keyword(s):  
Brain Damage ◽  
Serum Levels ◽  
Breath Hold ◽  
Long Term Effects ◽  
Arterial Blood ◽  
The Central Nervous System ◽  
Serious Injury ◽  
Protein S100b ◽  
The Brain ◽  
Damage Marker

The concentration of the protein S100B in serum is used as a brain damage marker in various conditions. We wanted to investigate whether a voluntary, prolonged apnea in trained breath-hold divers resulted in an increase of S100B in serum. Nine trained breath-hold divers performed a protocol mimicking the procedures they use during breath-hold training and competition, including extensive preapneic hyperventilation and glossopharyngeal insufflation, in order to perform a maximum-duration apnea, i.e., “static apnea” (average: 335 s, range: 281–403 s). Arterial blood samples were collected and cardiovascular variables recorded. Arterial partial pressures of O2 and CO2 (PaO2 and PaCO2) were 128 Torr and 20 Torr, respectively, at the start of apnea. The degree of asphyxia at the end of apnea was considerable, with PaO2 and PaCO2 reaching 28 Torr and 45 Torr, respectively. The concentration of S100B in serum transiently increased from 0.066 μg/l at the start of apnea to 0.083 μg/l after the apnea ( P < 0.05). The increase in S100B is attributed to the asphyxia or to other physiological responses to apnea, for example, increased blood pressure, and probably indicates a temporary opening of the blood-brain barrier. It is not possible to conclude that the observed increase in S100B levels in serum after a maximal-duration apnea reflects a serious injury to the brain, although the results raise concerns considering negative long-term effects. At the least, the results indicate that prolonged, voluntary apnea affects the integrity of the central nervous system and do not preclude cumulative effects.

scholarly journals Elevated Serum Protein S100B and Neuron Specific Enolase Values as Predictors of Early Neurological Outcome after Traumatic Brain Injury

2017 ◽  
Vol 36 (4) ◽  
pp. 314-321 ◽  
Author(s):  
Branislava Stefanović ◽  
Olivera Đurić ◽  
Sanja Stanković ◽  
Srđan Mijatović ◽  
Krstina Doklestić ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Serum Protein ◽  
Neurological Outcome ◽  
Brain Injuries ◽  
Elevated Serum ◽  
Neuron Specific Enolase ◽  
Poor Outcome ◽  
Protein S100b ◽  
The Brain

SummaryBackground: The objective of our study was to determine the serum concentrations of protein S100B and neuron specific enolase (NSE) as well as their ability and accuracy in the prediction of early neurological outcome after a traumatic brain injury. Methods: A total of 130 polytraumatized patients with the associated traumatic brain injuries were included in this prospective cohort study. Serum protein S100B and NSE levels were measured at 6, 24, 48 and 72 hours after the injury. Early neurological outcome was scored by Glasgow Outcome Scale (GOS) on day 14 after the brain injury. Results: The protein S100B concentrations were maximal at 6 hours after the injury, which was followed by an abrupt fall, and subsequently slower release in the following two days with continual and significantly increased values (p<0.0001) in patients with poor outcome. Secondary increase in protein S100B at 72 hours was recorded in patients with lethal outcome (GOS 1). Dynamics of NSE changes was characterized by a secondary increase in concentrations at 72 hours after the injury in patients with poor outcome. Conclusion: Both markers have good predictive ability for poor neurological outcome, although NSE provides better discriminative potential at 72 hours after the brain injury, while protein S100B has better discriminative potential for mortality prediction.

Evaluation of postmortem calcium and magnesium levels in the pericardial fluid with regard to the cause of death in medicolegal autopsy

2009 ◽  
Vol 11 ◽  
pp. S276-S278 ◽  
Author(s):  
Dong-Ri Li ◽  
Li Quan ◽  
Bao-Li Zhu ◽  
Takaki Ishikawa ◽  
Tomomi Michiue ◽  
...  
Keyword(s):  
Cause Of Death ◽  
Pericardial Fluid ◽  
Medicolegal Autopsy ◽  
Calcium And Magnesium

Medicolegal Autopsy: Histopathological Examination of Medicolegal Autopsy Cases and Its Correlation with Causes of Death

2021 ◽  
Vol 15 (5) ◽  
pp. 1495-1497
Author(s):  
S. S. A. Naqvi ◽  
Gulshad . ◽  
K. Sheikh ◽  
I. Wagan ◽  
A. Maher ◽  
...  
Keyword(s):  
Cause Of Death ◽  
Traffic Accidents ◽  
Causes Of Death ◽  
Histopathological Examination ◽  
Histopathological Analysis ◽  
Common Cause ◽  
Medical College ◽  
Medicolegal Autopsy ◽  
The Brain ◽  
Keywords Histopathology

Objective: The aim of this study is to determine the histopathological examination of medicolegal autopsy cases and its correlation with causes of death. Study Design: Retrospective/observational Place and Duration: This study was conducted at department of Pathology, Khairpur Medical College Khairpur Mir's for duration of eight months from 15thMay, 2020 to 15thJanuary, 2021. Methods: Hundred cases of both genders were presented in this study. Cases were aged between 15-75 years. Cases detailed demographics age, sex and body mass index were calculated after taking informed written consent from authorities. Autopsy laboratory was used to take medicolegal autopsies of enrolled cases. 10% formalin solution was used for histopathological examination of all the specimens. In the course of the post-mortem investigation we examined the histopathology results for five major organs, such as the brain, heart, lung, liver and kidneys and compared them with gross anatomical results. Complete data was analyzed by SPSS 24.0 version. Results: 62 (62%) cases were males and 38 (38%) patients were females. Mean age of the participants were 30.52±13.17 years with mean BMI 24.52±16.21kg/m2. Most of the participants 40 (40%) were aged between 25-35 years of age followed by 27 (27%) were aged between 36-45 years. Most of the participants 70 (70%) were from urban area and the rest were 30 (30%) from rural area. Instant death was the most common cause found in 35 (35%) cases, followed by traffic accidents 24 (24%) cases. Most frequent effected organs were lung 29%, heart 26%, liver 21% and brain 18%. In lungs pneumonia was the most common effected pathology among 20 (68.97%) and in heart atherosclerosis was the most common effected pathology among 21 (80.77%). Conclusion: In medicolegal autopsy cases, histopathological analysis may be regarded as a useful method. The most common organ in these cases were the heart, liver and lungs. In certain cases, the histopathological exam of these bodies has been useful in identifying the cause of death. Often pathological results included pneumonia, atherosclerosis and congestion. Keywords: Histopathology, Medicolegal, Cause of death, Autopsy

Postmortem serotonin levels in cerebrospinal and pericardial fluids with regard to the cause of death in medicolegal autopsy

2011 ◽  
Vol 13 (2) ◽  
pp. 75-78 ◽  
Author(s):  
Li Quan ◽  
Takaki Ishikawa ◽  
Junpei Hara ◽  
Tomomi Michiue ◽  
Jian-Hua Chen ◽  
...  
Keyword(s):  
Cause Of Death ◽  
Medicolegal Autopsy

Postmortem serum erythropoietin levels in establishing the cause of death and survival time at medicolegal autopsy

2008 ◽  
Vol 122 (6) ◽  
pp. 481-487 ◽  
Author(s):  
L. Quan ◽  
B.-L. Zhu ◽  
T. Ishikawa ◽  
T. Michiue ◽  
D. Zhao ◽  
...  
Keyword(s):  
Survival Time ◽  
Cause Of Death ◽  
Medicolegal Autopsy ◽  
Serum Erythropoietin

Postmortem catecholamine levels in pericardial and cerebrospinal fluids with regard to the cause of death in medicolegal autopsy

2013 ◽  
Vol 228 (1-3) ◽  
pp. 52-60 ◽  
Author(s):  
Takaki Ishikawa ◽  
Li Quan ◽  
Tomomi Michiue ◽  
Osamu Kawamoto ◽  
Qi Wang ◽  
...  
Keyword(s):  
Cause Of Death ◽  
Medicolegal Autopsy ◽  
Catecholamine Levels

Does Traumatic Donor Cause of Death Influence Outcome after Lung Transplantation? A Single-Centre Analysis

2015 ◽  
Vol 65 (05) ◽  
pp. 395-402 ◽  
Author(s):  
Jens Heckmann ◽  
Henning Carstens ◽  
Jura Lubarski ◽  
Heinz Jakob ◽  
Nikolaus Pizanis ◽  
...  
Keyword(s):  
Brain Injury ◽  
Lung Transplantation ◽  
Brain Damage ◽  
Cause Of Death ◽  
Statistical Significance ◽  
Graft Function ◽  
Young Male ◽  
Individual Case ◽  
Case Evaluation ◽  
Postoperative Ventilation

Background Owing to the shortage of donor organs in lung transplantation (LuTX), liberalization of donor selection criteria has been proposed. However, some studies suggested that donor traumatic brain damage might influence posttransplantation allograft function. This article aimed to investigate the association of donor cause of death (DCD) and outcome after LuTX. Methods A retrospective analysis of 186 consecutive double LuTXs at our institution from January 2000 to December 2008 was performed. DCD was categorized into traumatic brain injury (TBI) and nontraumatic brain injury (NTBI). In addition, NTBI was sub classified as spontaneous intracerebral bleeding (B), hypoxic brain damage (H), and intracerebral neoplasia (N). Results DCD was classified as TBI in 50 patients (26.9%) and NTBI in 136 patients (73.1%): B in 112 patients (60.2%), H in 21 patients (11.3%), and N in 3 patients (1.6%). Young male donors predominated in group TBI (mean age 36.0 ± 14.5 vs. 42.8 ± 10.7, p < 0.01; 29 males in the TBI group [58.0%] vs. 48 males in the NTBI group [35.3%], p < 0.01). Groups of DCD did not differ significantly by recipient age or gender, recipient diagnosis, donor ventilation time, or paO2/FiO2 before harvesting. TBI donors received significantly more blood (3.4 ± 3.8 vs. 1.8 ± 1.9, p = 0.03). A chest trauma was evident only in group T (n = 7 [3.7%] vs. 0 [0%], p < 0.001). Mode of donor death did not affect the following indices of graft function: length of postoperative ventilation, paO2/FiO2 ratio up to 48 hours, and lung function up to 36 months. One- and three-year survival was comparable with 84.4 and 70.4% for TBI donors versus 89.4% and 69.2% for NTBI donors. Five-year survival tended to be lower in the TBI group but did not reach statistical significance (43.4 vs. 53.9%). Conclusion This study indicates that traumatic DCD does not affect outcome after LuTX. These results can be achieved with an ideal donor management combined with an individual case-to-case evaluation by an experienced LuTX surgeon.

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