Oxidative stress may be involved in distant organ failure in tourniquet shock model mice

Abstract Background: Oxidative stress (OS) participates in the pathophysiology of patients with septic shock having multiple organ failure (MOF), ischemia-reperfusion injury and acute respiratory failure syndrome (ARDS). Antioxidants have been proposed in their therapy.Objective: To evaluate the effect of antioxidant treatment in patients with septic shock with MOF and levels OS after treatment.Research question: Will the administration of specific antioxidant therapy decrease deregulatory factors of oxidative stress and organ failure in patients with septic shock?Study design and Methods: Double-blind, placebo-controlled randomized clinical trial run in 2 ICU in Mexico City between May 2018 and January 2020. The random allocation sequence was generated using computer methods. Patients older than 18 years of either sex, with septic shock were included, were excluded when informed consent could not be obtained, they received chronic or recent use of steroids, statins, or antioxidants or if they had contraindications to the use of antioxidants. All antioxidants were administered by mouth or nasogastric tube during 5 days and were added to standard.Results: 97 patients were included with median age of 66 years. 20 were treated with MT and 18 with Vit C and they showed post-treatment decreased SOFA scores [p=0.007 and p<0.001 respectively]. Also, total antioxidant capacity (TAC) was improved by NAC. All patients had decreased basal levels of Vit C and patients that received Vit C had decreased levels of the NO3−/NO2− (p=0.02) and RCP levels [p=0.045]. Procalcitonin (PCT) levels were reduced by Vit E, [p=0.047], NAC; [p=0.001] and MT [p=0.045]. LPO was reduced in patients that received MT p=0.042 Conclusion: In septic shock, antioxidant therapy associated with standard intensive care unit therapy reduces MOF, the oxidative and inflammatory state. These results could be a reference to use adjuvant antioxidant therapy in patients with septic shock in COVID19.Trial Registration: ClinicalTrials.gov Identifier: NCT 03557229

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Questioning Current Concepts in Acute Pancreatitis: Endotoxin Contamination of Porcine Pancreatic Elastase is Responsible for Experimental Pancreatitis-Associated Distant Organ Failure

Zeitschrift für Gastroenterologie ◽

10.1055/s-2005-919961 ◽

2005 ◽

Vol 43 (05) ◽

Author(s):

F Geisler ◽

H Algül ◽

M Riemann ◽

RM Schmid

Keyword(s):

Acute Pancreatitis ◽

Organ Failure ◽

Experimental Pancreatitis ◽

Pancreatic Elastase ◽

Endotoxin Contamination ◽

Distant Organ ◽

Porcine Pancreatic Elastase

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N-Acetylcysteine Attenuates the Increasing Severity of Distant Organ Liver Dysfunction after Acute Kidney Injury in Rats Exposed to Bisphenol A

Antioxidants ◽

10.3390/antiox8100497 ◽

2019 ◽

Vol 8 (10) ◽

pp. 497 ◽

Cited By ~ 3

Author(s):

Wachirasek Peerapanyasut ◽

Anongporn Kobroob ◽

Siripong Palee ◽

Nipon Chattipakorn ◽

Orawan Wongmekiat

Keyword(s):

Oxidative Stress ◽

Acute Kidney Injury ◽

Liver Injury ◽

Bisphenol A ◽

Kidney Injury ◽

Causative Factor ◽

Mitochondrial Homeostasis ◽

Systemic Oxidative Stress ◽

Mitochondrial Functions ◽

Distant Organ

Distant organ liver damage after acute kidney injury (AKI) remains a serious clinical setting with high mortality. This undesirable outcome may be due to some hidden factors that can intensify the consequences of AKI. Exposure to bisphenol A (BPA), a universal chemical used in plastics industry, is currently unavoidable and can be harmful to the liver. This study explored whether BPA exposure could be a causative factor that increase severity of remote liver injury after AKI and examined the preventive benefit by N-acetylcysteine (NAC) in this complex condition. Male Wistar rats were given vehicle, BPA, or BPA + NAC for 5 weeks then underwent 45 min renal ischemia followed by 24 h reperfusion (RIR), a group of vehicle-sham-control was also included. RIR not only induced AKI but produced liver injury, triggered systemic oxidative stress as well as inflammation, which increasing severity upon exposure to BPA. Given NAC to BPA-exposed rats diminished the added-on effects of BPA on liver functional impairment, oxidative stress, inflammation, and apoptosis caused by AKI. NAC also mitigated the abnormalities in mitochondrial functions, dynamics, mitophagy, and ultrastructure of the liver by improving the mitochondrial homeostasis regulatory signaling AMPK-PGC-1α-SIRT3. The study demonstrates that NAC is an effective adjunct for preserving mitochondrial homeostasis and reducing remote effects of AKI in environments where BPA exposure is vulnerable.

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Effects of arterial oxygen content on oxidative stress during resuscitation in a rat hemorrhagic shock model

Resuscitation ◽

10.1016/j.resuscitation.2010.10.007 ◽

2011 ◽

Vol 82 (1) ◽

pp. 110-114 ◽

Cited By ~ 2

Author(s):

Akira Takasu ◽

Minori Shibata ◽

Shinya Uchino ◽

Kouichirou Nishi ◽

Yorihiro Yamamoto ◽

...

Keyword(s):

Oxidative Stress ◽

Hemorrhagic Shock ◽

Oxygen Content ◽

Arterial Oxygen ◽

Shock Model ◽

Arterial Oxygen Content ◽

Hemorrhagic Shock Model

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OXIDATIVE STRESS AND MULTI-ORGAN FAILURE IN HOSPITALIZED ELDERLY PEOPLE

Journal of the American Geriatrics Society ◽

10.1111/j.1532-5415.2008.01695.x ◽

2008 ◽

Vol 56 (6) ◽

pp. 1150-1152 ◽

Cited By ~ 4

Author(s):

James S. Powers ◽

L. Jackson Roberts ◽

Emily Tarvin ◽

Nobuko Hongu ◽

Leena Choi ◽

...

Keyword(s):

Oxidative Stress ◽

Organ Failure ◽

Elderly People ◽

Hospitalized Elderly ◽

Multi Organ Failure

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Review: Immunology of Sinusitis, Trauma, Asthma, and Sepsis

Allergy & Rhinology ◽

10.2500/ar.2015.6.0140 ◽

2015 ◽

Vol 6 (3) ◽

pp. ar.2015.6.0140 ◽

Cited By ~ 8

Author(s):

Marianne Frieri ◽

Krishan Kumar ◽

Anthony Boutin

Keyword(s):

Oxidative Stress ◽

Reactive Oxygen Species ◽

Vitamin D ◽

Seasonal Variation ◽

Organ Failure ◽

Chronic Rhinosinusitis ◽

Hereditary Angioedema ◽

Reactive Oxygen ◽

Oxygen Species ◽

Nf Kappa B

Background This review article is important for allergists/immunologists and otolaryngologists. It discussed chronic rhinosinusitis, epidemiology, pathogenesis, innate adaptive immunology, nuclear factor–kappa B related to inflammation, sepsis, complement, reactive oxygen species, asthma, sinusitis, elderly pathogenesis, oxidative stress, depression, seasonal variation, vitamin D, genetic susceptibility and sepsis, hereditary angioedema related to trauma and stress. Objective The objective of this review is to link chronic rhinosinusitis, epidemiology, innate and adaptive immunology, NF-kappa B related to inflammation, sepsis, complement, reactive oxygen species, asthma and sinusitis. Methods A literature search was conducted from several articles, prospective studies, recent reviews and earlier reports. A synergistic relationship develops between activation of the innate immune system and the loss of organ barrier functions. Many complex factors, such as genetics, physical agents, mediators in the development of organ failure both in asthma, sinusitis, stress, depression and trauma, leading to posttraumatic organ failure. Asthma and sepsis, a common condition encountered in hospital environments remains an important cause of death at intensive care units where allergists/immunologists and otolaryngologists are frequently consulted. The patient's immune surveillance could fail to eliminate the pathogen, allowing it to spread and there is a proinflammatory mediator release with inappropriate activation. Conclusion This review discussed chronic rhinosinusitis, sinusitis related to trauma, the innate and adaptive immunology, NF-kappa B related to inflammation, sepsis, complement, inflammation, reactive oxygen species, asthma pathogenesis, and asthma in the elderly, oxidative stress, depression, seasonal variation and vitamin D, cytokines, genetic susceptibility related to sepsis, hereditary angioedema related to trauma and stress.

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