Serotonin modulation in neonatal age does not impair cardiovascular physiology in adult female rats: Hemodynamics and oxidative stress analysis

Menopause is accompanied by enhanced oxidative stress and behavioral changes, effects attenuated by antioxidants. The aim of this study was to evaluate the effects of caffeine on behavior and oxidative stress in an experimental model of menopause. Female rats were divided into the following groups: sham-operated (CON), sham-operated and caffeine-treated (CAF), ovariectomized (OVX), ovariectomized and caffeine-treated (OVX+CAF). Caffeine (6 mg/kg) and vehicle were administered for 21 days (subchronic) and 42 days (chronic), using 2 experimental subsets. Behavioral tests and oxidative stress parameters in the blood, whole brain, and hippocampus were assessed. The subchronic administration of caffeine decreased the lipid peroxidation and improved the antioxidant defense in the blood and brain. The GSH/GGSG ratio in the brain was improved by chronic administration, with reduced activities of antioxidant enzymes and enhanced nitric oxide and malondialdehyde levels. In particular, the lipid peroxidation in the hippocampus decreased in both experiments. The rats became hyperactive after 21 days of treatment, but no effect was observed after chronic administration. In both experimental subsets, caffeine had anxiolytic effects as tested in elevated plus maze. The administration of low doses of caffeine, for a short period of time, may be a new therapeutic approach to modulating the oxidative stress and anxiety in menopause.

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Cholestasis-associated reproductive toxicity in male and female rats: The fundamental role of mitochondrial impairment and oxidative stress

Toxicology Letters ◽

10.1016/j.toxlet.2019.09.009 ◽

2019 ◽

Vol 316 ◽

pp. 60-72 ◽

Cited By ~ 9

Author(s):

Mohammad Mehdi Ommati ◽

Omid Farshad ◽

Hossein Niknahad ◽

Mohammad Reza Arabnezhad ◽

Negar Azarpira ◽

...

Keyword(s):

Oxidative Stress ◽

Reproductive Toxicity ◽

Female Rats ◽

Male And Female ◽

Mitochondrial Impairment ◽

Male And Female Rats ◽

And Oxidative Stress

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The Effects of Yellow Soybean, Black Soybean, and Sword Bean on Lipid Levels and Oxidative Stress in Ovariectomized Rats

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000010 ◽

2010 ◽

Vol 80 (2) ◽

pp. 97-106 ◽

Cited By ~ 23

Author(s):

Jae Soon Byun ◽

Young Sun Han ◽

Sang Sun Lee

Keyword(s):

Oxidative Stress ◽

Postmenopausal Women ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Thiobarbituric Acid ◽

Female Rats ◽

Ovariectomized Rats ◽

Lipid Levels ◽

Black Soybean ◽

And Oxidative Stress

Soy isoflavones have been reported to decrease the risk of atherosclerosis in postmenopausal women. However, the effects of dietary consumption of soybean have not been explored. In this study, we evaluated the effects of consuming yellow soybeans, black soybeans (Glycine max), or sword beans (Canavalia gladiate) on lipid and oxidative stress levels in an ovariectomized rat model. Forty-seven nine-week-old female rats were ovariectomized, randomly divided into four groups, and fed one of the following diets for 10 weeks: a diet supplemented with casein (NC, n = 12), a diet supplemented with yellow soybean (YS, n = 12), a diet supplemented with black soybean (BS, n = 12), or a diet supplemented with sword bean (SB, n = 11). Plasma triglyceride (TG) levels in the BS and SB groups were significantly lower than that in the NC group. Notably, the BS group had significantly lower plasma total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels than the other groups. Hepatic total lipid levels were significantly lower in the YS and SB groups, and cholesterol levels were significantly lower in the SB group than in the NC group. Superoxide dismutase (SOD) and catalase (CAT) activities were significantly higher in the groups fed beans compared to the NC group. Hepatic thiobarbituric acid reactive substances (TBARS) levels were also significantly lower in the BS and SB groups than the NC group. In conclusion, our results suggest that consumption of various types of beans may inhibit oxidative stress in postmenopausal women by increasing antioxidant activity and improving lipid profiles. Notably, intake of black soybean resulted in the greatest improvement in risk factors associated with cardiovascular disease.

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Effect of imidacloprid on antioxidant status and histopathological changes in ovary and uterus of adult female wistar rats

Indian Journal of Animal Research ◽

10.18805/ijar.b-3613 ◽

2018 ◽

Author(s):

Archana Lohiya ◽

Vinod Kumar ◽

J.S. Punia

Keyword(s):

Oxidative Stress ◽

Adult Female ◽

Wistar Rats ◽

Control Programme ◽

Female Rats ◽

Histopathological Changes ◽

Gum Acacia ◽

Flea Control ◽

Female Wistar Rats ◽

Neonicotinoid Insecticide

Imidacloprid is a neonicotinoid insecticide and has been extensively used as a crop pest and in pet flea control programme. In the present study, the effects of imidacloprid on ovary and uteri tissue was analyzed in adult female Wistar rats at two dose levels (19 and 38 mg/kg/day) administered orally for 10, 20 and 30 days. Effects were compared with respective control animals administered daily with 2% gum acacia. Parameters undertaken were organ weight, levels of cytoplasmic and membrane proteins, oxidative stress parameters viz. activities of SOD, GPx and levels of GSH and MDA and histopathological changes. IMI (38 mg/kg, 30 days) reduced cytoplamic proteins in both ovaries and uteri whereas this dose reduced membrane protein in ovaries only. IMI (38 mg/kg, 20 and 30 days) decreased SOD enzyme in both ovaries and uteri and GSH-Px levels in ovaries only. The GSH-Px levels were also seen with decreased levels in uteri with IMI (38 mg/kg) for 30 days. IMI (38 mg/kg, 20 and 30 days) induces degenerative changes in ovaries of rats. Hence, it is concluded from the present studies that administration of higher doses (38 mg/kg/day) of IMI for 20 and 30 days generated oxidative stress in ovaries and uteri of female rats.

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The Potential Role ofAzadirachta indicaTreatment on Cisplatin-Induced Hepatotoxicity and Oxidative Stress in Female Rats

Oxidative Medicine and Cellular Longevity ◽

10.1155/2013/741817 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 19

Author(s):

Mohamed A. Dkhil ◽

Saleh Al-Quraishy ◽

Ahmed M. Aref ◽

Mohamed S. Othman ◽

Kamal M. El-Deib ◽

...

Keyword(s):

Oxidative Stress ◽

Potential Role ◽

Female Rats ◽

Glutathione S Transferase ◽

Adult Rats ◽

Histological Changes ◽

Neem Leaves ◽

Antioxidant Parameters ◽

Apoptosis Markers ◽

And Oxidative Stress

Azadirachta indicaA. Juss. (neem, family: Meliaceae) is perhaps the most commonly used traditional medicinal plant of India. In this study we investigated the protective effect of methanolic neem leaves extract (MNLE; 500 mg/Kg bwt) on rats treated with cisplatin (CDDP)-induced hepatotoxicity. Adult rats were randomly divided into four groups. CDDP was given to rats by intraperitoneal injection, while MNLE was given by oral gavage for 5 days after the CDDP injection. The injury and oxidative stress caused by CDDP on the liver and the effect of MNLE were evaluated by measuring (a) histological changes, (b) tissue biochemical oxidant and antioxidant parameters, and (c) investigating apoptosis markers immunohistochemically and by real time PCR. After treatment with MNLE, the histological damage and apoptosis induction caused by cisplatin were improved. Malondialdehyde and nitric oxide were significantly decreased; the antioxidant system, namely, glutathione content, glutathione-S-transferase, glutathione peroxidase, catalase, and superoxide dismutase activities were significantly elevated. In conclusion, MNLE may have a potential role when combined with cisplatin in chemotherapy to alleviate cisplatin-induced damage and oxidative stress in liver.

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