Signal amplification strategy of label-free ultrasenstive electrochemical immunosensor based ternary Ag/TiO2/rGO nanocomposites for detecting breast cancer biomarker CA 15-3

2021 ◽  
pp. 124983
Author(s):  
Ahmed M. Shawky ◽  
Maha El-Tohamy
Keyword(s):  
Breast Cancer ◽  
Signal Amplification ◽  
Cancer Biomarker ◽  
Electrochemical Immunosensor ◽  
Label Free ◽  
Amplification Strategy

An electrochemical immunosensor for detection of a breast cancer biomarker based on antiHER2–iron oxide nanoparticle bioconjugates

The Analyst ◽  
2014 ◽  
Vol 139 (11) ◽  
pp. 2858-2866 ◽  
Author(s):  
Mahdi Emami ◽  
Mojtaba Shamsipur ◽  
Reza Saber ◽  
Rasoul Irajirad
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Cancer Biomarker ◽  
Electrochemical Immunosensor ◽  
Iron Oxide Nanoparticle ◽  
Label Free ◽  
Highly Sensitive ◽  
Oxide Nanoparticle

This paper presents a facile and highly sensitive label free electrochemical immunosensor for detection of a breast cancer biomarker using antiHER2–Fe3O4 NP bioconjugates.

A label-free and enzyme-free signal amplification strategy for a sensitive RNase H activity assay

Nanoscale ◽  
2017 ◽  
Vol 9 (42) ◽  
pp. 16149-16153 ◽  
Author(s):  
Chang Yeol Lee ◽  
Hyowon Jang ◽  
Ki Soo Park ◽  
Hyun Gyu Park
Keyword(s):  
Signal Amplification ◽  
Rnase H ◽  
Label Free ◽  
Activity Assay ◽  
G Quadruplex ◽  
Catalytic Hairpin Assembly ◽  
Amplification Strategy

A target-triggered catalytic hairpin assembly with a G-quadruplex specific fluorescent binder, NMM, is employed to develop a novel and sensitive RNase H activity assay.

scholarly journals Optical multiplexed bioassays on photonic crystals for breast cancer biomarker detection

2021 ◽  
Vol 255 ◽  
pp. 13003
Author(s):  
Tommaso Pileri ◽  
Alberto Sinibaldi ◽  
Agostino Occhicone ◽  
Elena Giordani ◽  
Matteo Allegretti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Specific Interaction ◽  
Fluorescence Emission ◽  
Optical Biosensor ◽  
Cancer Biomarker ◽  
Time Development ◽  
Biomarker Detection ◽  
Label Free ◽  
One Dimensional ◽  
Protein Bovine Serum Albumin

An optical biosensor for proteomic breast cancer biomarker detection in complex media is presented. Bloch Surface Waves (BSW) excited onto one dimensional photonic crystal (1DPC) were used to probe the interaction of HER2 with three antibody species and an inert protein (Bovine Serum Albumin - BSA). The optical system combines Label-Free readings to track the bioassay real-time development and Fluorescence emission quantification to evaluate the level of specific interaction between the antigen and the antibodies. The results confirm a distinguishable level of affinity between the antibodies and the analyte according to their specificity even at low antibody surface density (about 1173 pg/mm2).

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