Electrospun synthesis of silver/poly (vinyl alcohol) nano-fibers: Investigation of microstructure and antibacterial activity

2022 ◽  
Vol 309 ◽  
pp. 131370
Sara Azarakhsh ◽  
Hamed Bahiraei ◽  
Gholamhosain Haidari
Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 96
John Jackson ◽  
Helen Burt ◽  
Dirk Lange ◽  
In Whang ◽  
Robin Evans ◽  

The prompt treatment of burn wounds is essential but can be challenging in remote parts of Africa, where burns from open fires are a constant hazard for children and suitable medical care may be far away. Consequently, there is an unmet need for an economical burn wound dressing with a sustained antimicrobial activity that might be manufactured locally at low cost. This study describes and characterizes the novel preparation of a silver nitrate-loaded/poly(vinyl alcohol) (PVA) film. Using controlled heating cycles, films may be crosslinked with in situ silver nanoparticle production using only a low heat oven and little technical expertise. Our research demonstrated that heat-curing of PVA/silver nitrate films converted the silver to nanoparticles. These films swelled in water to form a robust, wound-compatible hydrogel which exhibited controlled release of the antibacterial silver nanoparticles. An optimal formulation was obtained using 5% (w/w) silver nitrate in PVA membrane films that had been heated at 140 °C for 90 min. Physical and chemical characterization of such films was complemented by in vitro studies that confirmed the effective antibacterial activity of the released silver nanoparticles against both gram positive and negative bacteria. Overall, these findings provide economical and simple methods to manufacture stable, hydrogel forming wound dressings that release antibiotic silver over prolonged periods suitable for emergency use in remote locations.

2021 ◽  
Vol 8 ◽  
Qi Liu ◽  
Wen-Chong Ouyang ◽  
Xiu-Hong Zhou ◽  
Tao Jin ◽  
Zheng-Wei Wu

In this study, nanofibers with different ratios of poly(vinyl alcohol) and chitosan incorporated with moxifloxacin hydrochloride (MH/PVA/CS) were fabricated through the blending electrospinning, and the morphological features were tested using scanning electron microscopy (SEM). Further characterization of the new nanofiber was accomplished by Thermogravimetric analysis (TG), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). Antibacterial activity of the MH-loaded nanofibers at different drug loading were tested and compared with the blank group. Experimental results show that the MH/PVA/CS nanofibers exhibited the good antibacterial properties against Staphylococcus aureus and Pseudomonas aeruginosa due to the MH incorporation. Compared with blank nanofibers, MH/PVA/CS nanofibers have significantly better antibacterial properties, and different proportions of PVA and CS have a certain effect on the antibacterial activity of nanofibers. The conclusions in this paper show that MH/PVA/CS composite nanofibers may have great potential in antibacterial materials.

2020 ◽  
Vol 10 (5) ◽  
pp. 6474-6480

Green synthesis of silver nanoparticles (AgNPs) using rice husk (RH) as low-cost agricultural waste material has been gaining importance in recent years. Meanwhile, poly (vinyl alcohol) (PVA) is reported to involve in the green production of AgNPs as low-cost, water-soluble, biocompatible and biodegradable stabilizing polymer. The present study is focussed on the green synthesis of poly (vinyl alcohol) (PVA) - silver nanoparticles (PVA-AgNPs) hybrid using rice husk extract as a reducing agent. The results recorded from UV–vis spectrum and transmission electron microscopy (TEM) support the characterization of AgNPs produced. Synthesised PVA-AgNPs hybrid revealed effective antibacterial activity against Escherichia coli and Bacillus sp.

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Ivana Veverková ◽  
Irena Lovětinská-Šlamborová

This study is focused on development of functionalized inorganic-organic nanofibrous material with antibacterial activity for wound dressing applications. The nanofibers combining poly(vinyl alcohol) and silica were produced by electrospinning from the sol and thermally stabilized. The PVA/silica nanofibers surface was functionalized by silver and copper nanoparticles to ensure antibacterial activity. It was proven that quantity of adsorbed silver and copper nanoparticles depends on process time of adsorption. According to antibacterial tests results, this novel nanofibrous material shows a big potential for wound dressing applications due to its significant antibacterial efficiency.

2021 ◽  
pp. 096739112110206
Fika Fauzi ◽  
Muhammad Miqdam Musawwa ◽  
Habibi Hidayat ◽  
Ahmad Kusumaatmaja ◽  
Wipsar Sunu Brams Dwandaru

Recently, antibacterial coatings based on graphene oxide (GO) nanocomposites have attracted many studies around the world. The use of polymers as the matrices of GO nanofillers in the nanocomposites has been explored to produce efficient coatings against bacteria. One of the most prospective applications is the incorporation of GO into biocompatible polymers, which can produce antibacterial coatings. Here, recent progresses on the antibacterial coatings of nanocomposites based on biocompatible polymers and GO are reviewed. The effect of GO filler concentrations, biocide materials, and biocompatibility are discussed to find the most efficient antibacterial activity and biocompatibility of nanocomposites. Among biocompatible polymers, chitosan (Cs), poly vinyl alcohol (PVA), and poly lactic acid (PLA) are the most popular matrices used for the nanocomposites. This review also elaborates challenges in the use of other biocompatible polymers. Future works on biocompatible antibacterial coatings should be conducted by considering the concentration of GO nanofillers or adding other materials such as essential oils to suppress the toxicity toward functional cells.

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