scholarly journals Carotid Artery Intima-Media Thickness and Subclinical Atherosclerosis in Women With Remote Histories of Preeclampsia: Results From a Rochester Epidemiology Project-Based Study and Meta-analysis

2017 ◽  
Vol 92 (9) ◽  
pp. 1328-1340 ◽  
Author(s):  
Vesna D. Garovic ◽  
Natasa M. Milic ◽  
Tracey L. Weissgerber ◽  
Michelle M. Mielke ◽  
Kent R. Bailey ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Meta Analysis ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Media Thickness ◽  
Rochester Epidemiology Project

Validation of an Automated Computerized Analyzing System for Measuring Common Carotid Artery Intima–Media Thickness by Brightness Mode Ultrasound

2005 ◽  
Vol 29 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Helmuth F. Fritz ◽  
Roy V. Jutzy ◽  
Ramesh Bansal ◽  
Linda Housten-Feenstra
Keyword(s):  
Carotid Artery ◽  
Validation Study ◽  
Common Carotid Artery ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Accuracy Analysis ◽  
Electronic Instrument ◽  
Carotid Ultrasound ◽  
Media Thickness ◽  
The Mean

Background and Purpose Evaluation of subclinical atherosclerosis by B-mode carotid ultrasound intima–media thickness (IMT) is an endorsed technique whose ease and precision is improved by use of automated IMT measurement algorithms. We report results of a validation study of SonoCalc, an automated IMT software program. Methods Three vascular sonographers measured the mean common carotid artery IMT twice of 120 near and far wall CCA segments from 30 subjects by manual electronic instrument calipers and with SonoCalc. Results Accuracy analysis indicated the equivalence of SonoCalc IMT measurements to those with manual electronic instrument calipers ( p < 0.0001). The coefficient of variation (CV) was calculated for each set of duplicate SonoCalc and manual electronic instrument calipers measurements. The average SonoCalc-manual electronic instrument calipers CV differences significantly favored SonoCalc ( p < 0.0001). Conclusion This study demonstrated that the use of the SonoCalc and the manual electronic instrument calipers produced measurements whose differences were statistically insignificant. Furthermore, the analysis to assess reproducibility of the two methods showed that the SonoCalc method was significantly more reproducible than the manual electronic instrument calipers methods.

scholarly journals Serum Fasting Non-esterified Fatty Acids and Carotid Artery Intima-Media Thickness in Older Adults: The Cardiovascular Health Study

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1043-1043
Author(s):  
Neil Huang ◽  
Petra Bůžková ◽  
Nirupa Matthan ◽  
Luc Djoussé ◽  
Jorge Kizer ◽  
...  
Keyword(s):  
Older Adults ◽  
Carotid Artery ◽  
Cardiovascular Health ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Fasting Serum ◽  
Media Thickness ◽  
Linoelaidic Acid

Abstract Objectives Carotid artery intima-media thickness (CIMT) has been used as an early indicator of subclinical atherosclerosis. Multiple studies have identified significant associations between plasma total non-esterified fatty acid (NEFA) concentrations and risk factors associated with subclinical atherosclerosis. However, the relationship between CIMT and serum NEFA is less clear. We hypothesized fasting serum total, individual saturated, and trans NEFA are positively associated with, and individual monounsaturated, n-6 polyunsaturated (PUFA) and n-3 PUFA NEFA are inversely associated with, CIMT. Methods We investigated the associations between fasting serum NEFA, and CIMT assessed in 1998–1999 among Cardiovascular Health Study (CHS) participants (N = 1,569) not taking anti-diabetic medication. A total of 35 individual NEFAs were measured in stored specimens from 1996–1997 using gas chromatography. CIMT was determined using ultrasound images, and was defined as the sum of the maximum common CIMT at the far wall divided by its standard deviation (SD) and the maximum internal CIMT at the far wall divided by its SD. At baseline, mean age was 77.3 ± 4.2, body mass index (BMI) was 26.8 ± 4.3 and 64% were female. Associations were assessed by linear regression, with adjustments for other individual NEFAs, age, sex, race, field center, education, smoking, BMI, physical activity, alcohol consumption, eGFR, serum albumin, hyperglycemia, hypertension, use of anti-hypertensive, statin, and other lipid-lowering drugs. Results In adjusted models per SD increment, linoelaidic acid (trans18:2) was positively associated with CIMT [β (95% confidence interval): 10.4 (0.99, 19.8), P = 0.03], and α-linolenic acid (18:3n-3) was marginally associated with lower CIMT [−21.2 (−42.6, 0.2), P = 0.05]. No significant associations were observed between total NEFAs or any other individual NEFAs (SFA, MUFA, and n-6 PUFA) and CIMT. Conclusions In this large community-based cohort of older adults, higher concentration of linoelaidic acid was positively associated with CIMT, suggesting the importance of partially hydrogenated fat in the development of subclinical atherosclerosis in older adults. Overall, however, serum fasting NEFAs were largely unrelated to subclinical atherosclerosis in CHS participants. Funding Sources NIH, NHLBI, USDA.

The Variation in Cholesterol and Triglycerides Levels and the Risk for Stroke in First Degree Relatives of Stroke Patients

2018 ◽  
Vol 69 (11) ◽  
pp. 3068-3071
Author(s):  
Cristina Grosu ◽  
Alexandra Mastaleru ◽  
Victor Vlad Costan ◽  
Otilia Nita ◽  
Maria Magdalena Leon Constantin
Keyword(s):  
Carotid Artery ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Cerebrovascular Diseases ◽  
Control Group ◽  
Stroke Patients ◽  
Mean Values ◽  
First Degree Relatives ◽  
Media Thickness ◽  
Stroke Group

Cerebrovascular diseases have become a leading cause of mortality and major invalidity throughout the world in the last years. The levels of cholesterol and triglycerides are among the modifiable risk factors for stroke. The intima media thickness (IMT) is a very good marker for subclinical atherosclerosis and also for predicting future cardio- and cerebrovascular events. The aim of this study was to determine correlations between the lipid profile and the value of the intima media thickness as a risk factor for stroke in first degree relatives of stroke patients. We evaluated a total of 176 subjects, selected by well defined criteria, divided into three groups: stroke patients, first degree relatives of stroke patients and a healthy control group. We measured weight, height and body mass index, the levels of cholesterol and triglycerides, and IMT by cervical ultrasound mode B, at the common carotid artery (CCA) and internal carotid artery (ICA) bilaterally. The mean values of lipids were in the normal range. However, in the stroke group, both cholesterol and triglyceride levels were increased compared to the other groups. The triglycerides level positively correlated with IMT in the CCA in both control and stroke patients, but this was not the case for cholesterol levels. Also, the increase in IMT in stroke patients correlated with an increase in IMT of their relatives. Further research is needed in order to elaborate a screening algorithm for primary prevention of stroke in first degree relatives of stroke patients.

scholarly journals Association of α2-Heremans-Schmid Glycoprotein Polymorphisms with Subclinical Atherosclerosis

2007 ◽  
Vol 92 (1) ◽  
pp. 345-352 ◽  
Author(s):  
Allison B. Lehtinen ◽  
Kathryn P. Burdon ◽  
Joshua P. Lewis ◽  
Carl D. Langefeld ◽  
Julie T. Ziegler ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Carotid Artery ◽  
Atherosclerotic Plaque ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Fetuin A ◽  
Media Thickness ◽  
European Americans ◽  
Calcified Plaque ◽  
Ahsg Gene

Abstract Context: Cardiovascular disease is significantly increased in individuals with type 2 diabetes mellitus (T2DM), especially in the presence of calcified atherosclerotic plaque. Fetuin A is an important mineralization inhibitor, and polymorphisms in the corresponding α2-Heremans-Schmid glycoprotein (AHSG) gene have been shown to be associated with serum fetuin A levels and free phosphate levels, as well as cardiovascular disease death. Objective: This study investigated whether polymorphisms in AHSG contribute to the development of calcified atherosclerotic plaque in the coronary and carotid arteries and to carotid artery intima-media thickness. Design: Eleven single nucleotide polymorphisms (SNPs) in AHSG were genotyped and evaluated for association with quantitative measures of subclinical atherosclerosis. Participants: Subjects were 829 T2DM-affected European Americans from 368 families in the Diabetes Heart Study. Main Outcome Measures: Participants were phenotyped for cardiovascular risk factors and atherosclerosis traits. The extent of coronary artery calcified plaque (CorCP) and carotid artery calcified plaque (CarCP) was measured using quantitative computed tomography, and carotid artery intima-media thickness was measured using high-resolution B mode ultrasonography. Results: Four SNPs in AHSG were nominally associated with CorCP in European Americans with T2DM (P &lt; 0.05). Two 3-SNP haplotypes in the exon 6–7 region were associated with CorCP in European Americans with T2DM (P &lt; 0.06). Conclusions: Sequence variants in the AHSG gene affect the extent of CorCP in T2DM-affected European Americans, consistent with the known biological role of AHSG in vascular calcification. These data implicate AHSG in the development of vascular calcified plaque in diabetic subjects.

scholarly journals Carotid artery intima-media thickness in polycystic ovary syndrome: a systematic review and meta-analysis

2011 ◽  
Vol 18 (2) ◽  
pp. 112-126 ◽  
Author(s):  
Michelle L. Meyer ◽  
Angela M. Malek ◽  
Robert A. Wild ◽  
Mary T. Korytkowski ◽  
Evelyn O. Talbott
Keyword(s):  
Systematic Review ◽  
Carotid Artery ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Intima Media Thickness ◽  
Ovary Syndrome ◽  
Media Thickness

scholarly journals Age, gender and hypertension as major risk factors in development of subclinical atherosclerosis

2013 ◽  
Vol 3 (1) ◽  
pp. 26-29
Author(s):  
Ajla Rahimić Ćatić ◽  
Sandra Vegar Zubović ◽  
Jasminka Ðelilović Vranić ◽  
Svjetlana Lozo
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Carotid Artery ◽  
Early Detection ◽  
Common Carotid Artery ◽  
Carotid Atherosclerosis ◽  
Heart Diseases ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Media Thickness

Introduction: Intima-media thickness (IMT) measurement of the common carotid artery (CCA) is considered as useful indicator of carotid atherosclerosis. Early detection of atherosclerosis and its associated risk factors is important to prevent stroke and heart diseases. The aim of the present study was to investigate which risk factors are better determinants of subclinical atherosclerosis, measured by common carotidartery intima media thickness (CCA-IMT).Methods: A total of 74 subjects were randomly selected in this cross – sectional study. Information on the patient’s medical history and laboratory fi ndings were obtained from their clinical records. Risk factors relevant to this study were age, gender, cigarette smoking status, diabetes, hypertension and dyslipidemia. Ultrasound scanning of carotid arteries was performed with a 7,5 MHz linear array transducer (GE Voluson730 pro). The highest value of six common carotid artery measurements was taken as the fi nal IMT. Increased CCA-IMT was defi ned when it was > 1 mm.Results: Our data demonstrated higher CCA-IMT values in male patients compared with female patients. Increased CCA-IMT was the most closely related to age (P<0.001), followed by systolic blood pressure (P=0.001), diastolic blood pressure (P=0.003) and glucose blood level (P=0.048).Conclusion: Age, gender and hypertension are the most important risk factors in development of carotid atherosclerosis. Early detection of atherosclerosis among high-risk populations is important in order to prevent stroke and heart diseases, which are leading causes of death worldwide.

scholarly journals Biomarkers of Cardiovascular Stress and Subclinical Atherosclerosis in the Community

2014 ◽  
Vol 60 (11) ◽  
pp. 1402-1408 ◽  
Author(s):  
Deepa M Gopal ◽  
Martin G Larson ◽  
James L Januzzi ◽  
Susan Cheng ◽  
Anahita Ghorbani ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Carotid Plaque ◽  
Troponin I ◽  
Subclinical Atherosclerosis ◽  
Logistic Models ◽  
High Sensitivity ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Cardiovascular Stress

Abstract BACKGROUND Biomarkers of cardiovascular stress have been associated with incident cardiovascular outcomes. Their relations with measures of subclinical atherosclerosis, as assessed by carotid intima-media thickness, have not been well described. METHODS We measured plasma growth differentiation factor-15 (GDF-15), soluble ST2 (sST2), and high-sensitivity troponin I (hsTnI) in 3111 Framingham Offspring participants who also underwent carotid ultrasonography during the sixth examination (1995–1998, mean age 58 years, 54% women). Carotid measurements included maximal internal carotid artery (ICA) intima-media thickness (IMT), plaque presence (defined as ICA IMT &gt;1.5 mm), and mean common carotid artery IMT. We carried out multivariable regressions for carotid measurements vs biomarkers using linear and logistic models; P &lt; 0.0056 was deemed statistically significant. RESULTS Maximal ICA IMT was significantly associated with plasma GDF-15 [β-estimate 0.04 per 1-U increase in log(GDF-15), SE 0.01, P &lt; 0.0001]. Similarly, the odds of having carotid plaque increased 33% [odds ratio 1.33 per 1-U increase in log(GDF-15), 95% CI 1.20–1.48, P &lt; 0.0001]. In contrast, there was no significant association of maximal ICA IMT or plaque presence with sST2 or hsTnI, and none of the 3 biomarkers was significantly associated with mean CCA IMT. GDF-15 was a stronger predictor of maximal ICA thickness and plaque presence compared with BNP and CRP when these conventional biomarkers were tested together. CONCLUSIONS Increased GDF-15 concentrations are associated with subclinical atherosclerosis, including maximal ICA IMT and carotid plaque presence. Future studies investigating the role of GDF-15 for screening and management of patients with subclinical atherosclerosis are warranted.

Sign in / Sign up

Export Citation Format

Share Document