Epigenetic-related gene expression profile in medullary thyroid cancer revealed the overexpression of the histone methyltransferases EZH2 and SMYD3 in aggressive tumours

2014 ◽  
Vol 392 (1-2) ◽  
pp. 8-13 ◽  
Author(s):  
Marialuisa Sponziello ◽  
Cosimo Durante ◽  
Amelie Boichard ◽  
Mariavittoria Dima ◽  
Cinzia Puppin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Cancer ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Medullary Thyroid Cancer ◽  
Related Gene ◽  
Histone Methyltransferases ◽  
Medullary Thyroid

scholarly journals Differences in the transcriptome of medullary thyroid cancer regarding the status and type of RET gene mutations

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Malgorzata Oczko-Wojciechowska ◽  
Michal Swierniak ◽  
Jolanta Krajewska ◽  
Malgorzata Kowalska ◽  
Monika Kowal ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Cancer ◽  
Gene Mutation ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Medullary Thyroid Cancer ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Tumour Suppressor Gene ◽  
Medullary Thyroid

Abstract Medullary thyroid cancer (MTC) can be caused by germline mutations of the RET proto-oncogene or occurs as a sporadic form. It is well known that RET mutations affecting the cysteine-rich region of the protein (MEN2A-like mutations) are correlated with different phenotypes than those in the kinase domain (MEN2B-like mutations). Our aim was to analyse the whole-gene expression profile of MTC with regard to the type of RET gene mutation and the cancer genetic background (hereditary vs sporadic). We studied 86 MTC samples. We demonstrated that there were no distinct differences in the gene expression profiles of hereditary and sporadic MTCs. This suggests a homogeneous nature of MTC. We also noticed that the site of the RET gene mutation slightly influenced the gene expression profile of MTC. We found a significant association between the localization of RET mutations and the expression of three genes: NNAT (suggested to be a tumour suppressor gene), CDC14B (involved in cell cycle control) and NTRK3 (tyrosine receptor kinase that undergoes rearrangement in papillary thyroid cancer). This study suggests that these genes are significantly deregulated in tumours with MEN2A-like and MEN2B-like mutations; however, further investigations are necessary to demonstrate any clinical impact of these findings.

scholarly journals The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells

2007 ◽  
Vol 67 (14) ◽  
pp. 6956-6964 ◽  
Author(s):  
Nagako Akeno-Stuart ◽  
Michelle Croyle ◽  
Jeffrey A. Knauf ◽  
Roberta Malaguarnera ◽  
Donata Vitagliano ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Cancer ◽  
Cancer Cells ◽  
Medullary Thyroid Cancer ◽  
Kinase Inhibitor ◽  
Medullary Thyroid ◽  
Calcitonin Gene ◽  
Thyroid Cancer Cells

scholarly journals Angiogenesis-related gene expression profile in clinical cases of canine cancer

2018 ◽  
Vol 5 (1) ◽  
pp. 19-29
Author(s):  
Atsushi Tanabe ◽  
Daisuke Kobayashi ◽  
Koki Maeda ◽  
Masayuki Taguchi ◽  
Hiroeki Sahara
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Related Gene ◽  
Canine Cancer ◽  
Angiogenesis Related Gene ◽  
Clinical Cases

Immune response-related gene expression profile of a novel molluscan IκB protein member from Manila clam (Ruditapes philippinarum)

2012 ◽  
Vol 40 (2) ◽  
pp. 1519-1527 ◽  
Author(s):  
Youngdeuk Lee ◽  
Wickramaarachchige Don Niroshana Wickamarachchi ◽  
Ilson Whang ◽  
Minyoung Oh ◽  
Navaneethaiyer Umasuthan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Immune Response ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Ruditapes Philippinarum ◽  
Manila Clam ◽  
Related Gene

A spermatogenesis-related gene expression profile in human spermatozoa and its potential clinical applications

2004 ◽  
Vol 82 (5) ◽  
pp. 317-324 ◽  
Author(s):  
Hui Wang ◽  
Zuomin Zhou ◽  
Min Xu ◽  
Jianmin Li ◽  
Junhua Xiao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Clinical Applications ◽  
Human Spermatozoa ◽  
Related Gene
Sign in / Sign up

Export Citation Format

Share Document