ProstAttention-Net: a deep attention model for prostate cancer segmentation by aggressiveness in MRI scans

2022 ◽  
pp. 102347
Author(s):  
Audrey Duran ◽  
Gaspard Dussert ◽  
Olivier Rouviére ◽  
Tristan Jaouen ◽  
Pierre-Marc Jodoin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Attention Model ◽  
Mri Scans

Acute and subacute prostate MRI findings after MRI-guided transurethral ultrasound ablation of prostate cancer

2020 ◽  
pp. 028418512097693
Author(s):  
Pietari Mäkelä ◽  
Mikael Anttinen ◽  
Visa Suomi ◽  
Aida Steiner ◽  
Jani Saunavaara ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Diagnostic Value ◽  
Optimal Timing ◽  
Mri Findings ◽  
Apparent Diffusion Coefficient Values ◽  
Mri Scans ◽  
Ultrasound Ablation ◽  
Mri Guided ◽  
Transurethral Ultrasound

Background Magnetic resonance imaging (MRI)-guided transurethral ultrasound ablation (TULSA) is an emerging method for treatment of localized prostate cancer (PCa). TULSA-related subacute MRI findings have not been previously characterized. Purpose To evaluate acute and subacute MRI findings after TULSA treatment in a treat-and-resect setting. Material and Methods Six men with newly diagnosed MRI-visible and biopsy-concordant clinically significant PCa were enrolled and completed the study. Eight lesions classified as PI-RADS 3–5 were focally ablated using TULSA. One- and three-week follow-up MRI scans were performed between TULSA and robot-assisted laparoscopic prostatectomy. Results TULSA-related hemorrhage was detected as a subtle T1 hyperintensity and more apparent T2 hypointensity in the MRI. Both prostate volume and non-perfused volume (NPV) markedly increased after TULSA at one week and three weeks after treatment, respectively. Lesion apparent diffusion coefficient values increased one week after treatment and decreased nearing the baseline values at the three-week MRI follow-up. Conclusion The optimal timing of MRI follow-up seems to be at the earliest at three weeks after treatment, when the post-procedural edema has decreased and the NPV has matured. Diffusion-weighted imaging has little or no added diagnostic value in the subacute setting.

11C-choline PET scanning is more accurate than biopsy in assessment of localized prostate cancer planned for radical prostatectomy.

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 182-182
Author(s):  
Ian D. Davis ◽  
Sze Ting Lee ◽  
Lekshmy Shanker ◽  
David Clouston ◽  
Damien M Bolton ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Treatment Plan ◽  
Curative Intent ◽  
Trus Biopsy ◽  
Department Of Health ◽  
Imaging Results ◽  
Mri Scans ◽  
Treat Prostate Cancer ◽  
Ct And Mri

182 Background: A decision to treat prostate cancer (PC) with radical prostatectomy (RP) with curative intent requires confidence that the PC is confined to the prostate. PC outcomes will improve with better selection of surgical candidates. Current imaging modalities include CT and MRI but have limited accuracy. We assessed 18F-FDG (FDG) and 11C-choline (CHOL) PET in men planned for RP to determine the accuracy of PET, effects of PET on decision making by surgeons, and correlation with PSA. Methods: Written informed consent was obtained from eligible participants (pts) planned for RP. All men underwent TRUS-guided prostatic biopsies, CT and MRI scans, PSA and standard tests of organ function. The urologist then documented the treatment plan based on these results. Pts then underwent FDG and CHOL PET and the urologist then determined whether this information altered the treatment plan. After surgery the RP specimen was reconstructed, examined histologically and correlated with TRUS and imaging results on a sextant-based analysis (apex/mid/base on both sides). Results: 30 pts entered and completed the trial. Outcomes are shown in the table. Neither PET modality significantly affected decisions about surgery. Preoperative PSA did not correlate with degree of involvement. FDG PET was unhelpful. Conclusions: CHOL PET was the most sensitive and most accurate modality with highest congruity with pathology and had excellent positive predictive value, but was least specific. CHOL PET was superior to both TRUS biopsy and MRI. Supported by grant 487916 through Cancer Australia, Prostate Cancer Foundation Australia, Australian Government Department of Health and Aging. [Table: see text]

Location of local recurrence after MRI-guided partial prostate brachytherapy targeting only the peripheral zone: Implications for focal therapy.

2013 ◽  
Vol 31 (6_suppl) ◽  
pp. 149-149 ◽  
Author(s):  
Konstantin Kovtun ◽  
Tobias Penzkofer ◽  
Neha Agrawal ◽  
Tina Kapur ◽  
Andriy Fedorov ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Local Recurrence ◽  
Central Zone ◽  
Peripheral Zone ◽  
Focal Therapy ◽  
Prostate Brachytherapy ◽  
Local Recurrences ◽  
Endorectal Coil ◽  
Mri Scans ◽  
Mri Guided

149 Background: Prostate cancer local recurrences usually occur at the same site as the dominant primary tumor in patients treated with radiation therapy to the whole gland. We characterized location of local recurrences in patients who were treated with MRI Guided Partial Brachytherapy in which only the peripheral zone was targeted. Methods: We retrospectively reviewed ten patients with initial cT1c, Gleason score 3+4 or less prostate cancer who developed biopsy proven local recurrences and had available imaging after MRI Guided Partial Brachytherapy targeting the peripheral zone from 1998 to 2006. All 10 patients had 1.5T endorectal coil MRI at diagnosis, performed primarily for staging and not for tumor localization, while at recurrence 8 had 3T endorectal coil MRI and 2 had 1.5T endorectal coil MRI. Scans consisted of at least T1 and T2 sequences. Two radiologists (C.T. and T.P.) blinded to clinical data reviewed diagnosis MRI scans together and quantified likelihood of tumor on a 1 to 5 scale in each section of an eight part prostate in both pre-treatment and recurrence scans. Local recurrence was judged to be in the same location as the baseline tumor if at least 50% of the tumor location overlapped. Results: Only 3 of 10 patients had local recurrences at the same location as the baseline tumor with a mean overlap of 64%. 7 of 10 patients had local recurrences at a different location with a mean overlap of 5%. 5 of 10 patients had recurrences in the central zone of the prostate which did not definitively show tumor on review of the initial 1.5T staging scan. Conclusions: After MRI-guided brachytherapy targeting only the peripheral zone in men initially staged with 1.5T MRI, 50% of the local recurrences occurred at the non-targeted central zone, raising the possibility that focal therapy directed only at the dominant tumor will result in increased out-of-field recurrences. Whether the superior ability of modern 3T multiparametric MRI to detect and precisely localize occult prostate cancer foci will reduce this risk is the subject of current study.

scholarly journals Does urethral length affect continence outcomes following robot assisted laparoscopic radical prostatectomy (RALP)?

2019 ◽  
Author(s):  
Diwei Lin ◽  
Michael E O'Callaghan ◽  
Rowan David ◽  
Andrew Fuller ◽  
Richard Wells ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Short Form ◽  
High Volume ◽  
Urinary Continence ◽  
Resonance Imaging ◽  
Robot Assisted ◽  
Mri Scans ◽  
Magnetic Resonance Imaging Mri ◽  
Radiotherapy Treatment

Abstract Purpose Post-operative urinary incontinence is a significant concern for patients choosing to undergo a radical prostatectomy (RP) for treatment of prostate cancer. The aim of our study was to determine the effect of pre-operative MUL on 12 month continence outcomes in men having robot-assisted laparoscopic prostatectomy (RALP).Methods We use the South Australian Prostate Cancer Clinical Outcomes Collaborative (SA-PCCOC) database, to identify 602 patients who had undergone RALP by a high volume surgeon. Only patients who received an assessment and education by a specialist pelvic floor physiotherapist, had completed EPIC questionnaires before treatment and did not have radiotherapy treatment within 12 months of surgery were included. MUL measurements were taken from pre-operative magnetic resonance imaging (MRI) scans. The short-form version of the Expanded Prostate Cancer Index Composite (EPIC-26) was used to measure continence outcomes. Continence was defined as 100/100 in the EPIC-26 Urinary Continence domain score.Results The observed median MUL in this study was 14.6mm. There was no association between MUL and baseline continence. MUL was associated with continence at 12 months post RALP (OR 1.13, 95% CI 1.03-1.21, p=0.0098). In men who were continent before surgery, MUL was associated with return to continence at 12 months after RALP (OR 1.15, 1.05-1.28, p=0.006). MUL was also associated with change in continence after surgery (β=1.22, p=0.002).Conclusions MUL had no effect on baseline continence but had a positive and significant association with continence outcomes over 12 months post RALP.

scholarly journals Delivering Clinical impacts of the MRI diagnostic pathway in prostate cancer diagnosis

2020 ◽  
Vol 45 (12) ◽  
pp. 4012-4022
Author(s):  
Ivo G. Schoots ◽  
Anwar R. Padhani
Keyword(s):  
Prostate Cancer ◽  
Multiparametric Mri ◽  
Net Benefit ◽  
High Risk Factors ◽  
Improve Risk Stratification ◽  
Trade Offs ◽  
Before And After ◽  
Mri Scans ◽  
Clinical Benefits ◽  
Diagnostic Work

AbstractPre-biopsy multiparametric MRI is now recommended by multiple guidelines, not only for men with persistent suspicion of prostate cancer after prior negative systematic biopsy, but also at initial screening before the first biopsy. The major benefit of pre-biopsy MRI in the diagnostic work-up is to promote individualized risk-adapted approaches for biopsy-decision management. Multiple MRI-directed diagnostic pathways can be conceived, with each approach having net-benefit trade-offs between benefits and harms, based on improved diagnostic yields of significant cancers and reduced biopsy testing and reduced detection of indolent prostate cancer. In this paper, we illustrate how clinical benefits can be maximized in men with MRI-negative and MRI-positive results, using the PI-RADS Multiparametric MRI and MRI-directed biopsy pathway. From a practice perspective, we emphasize five golden rules: (1) that multiparametric MRI approach including targeted biopsies be reserved for men likely to benefit from early detection and treatment of prostate cancer; (2) that there is a need to carefully assess risk of significant disease using PSA and clinical parameters before and after MRI; (3) do not offer immediate biopsy if the MRI is negative, unless other high-risk factors are present; (4) accept that not all significant cancers are found immediately and have robust ‘safety nets’ for men with negative MRI scans who avoid immediate biopsy and for positive MRI patients with negative or non-explanatory histology; and (5) use MRI-directed biopsy methods that minimize overdiagnosis and improve risk stratification.

Detection of clinically relevant prostate cancer from multi-parametric 3Tesla MRI scans using artificial intelligence

2019 ◽  
Vol 18 (6) ◽  
pp. e2722
Author(s):  
A. Aydin ◽  
C. Kahir ◽  
M. Patel ◽  
C. Allen ◽  
P. Dasgupta
Keyword(s):  
Prostate Cancer ◽  
Artificial Intelligence ◽  
Mri Scans

scholarly journals MRI scans significantly change target coverage decisions in radical radiotherapy for prostate cancer

2013 ◽  
Vol 58 (2) ◽  
pp. 237-243 ◽  
Author(s):  
Joe H. Chang ◽  
Daryl Lim Joon ◽  
Brandon T. Nguyen ◽  
Chee-Yan Hiew ◽  
Stephen Esler ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Target Coverage ◽  
Radical Radiotherapy ◽  
Mri Scans ◽  
Change Target

scholarly journals Using IVIM Parameters to Differentiate Prostate Cancer and Contralateral Normal Tissue through Fusion of MRI Images with Whole-Mount Pathology Specimen Images by Control Point Registration Method

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2340
Author(s):  
Cheng-Chun Lee ◽  
Kuang-Hsi Chang ◽  
Feng-Mao Chiu ◽  
Yen-Chuan Ou ◽  
Jen-I. Hwang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Image Fusion ◽  
Normal Tissue ◽  
Control Point ◽  
Fusion Method ◽  
Registration Method ◽  
Whole Mount ◽  
Mri Scans ◽  
Pathology Specimen ◽  
Image Fusion Method

The intravoxel incoherent motion (IVIM) model may enhance the clinical value of multiparametric magnetic resonance imaging (mpMRI) in the detection of prostate cancer (PCa). However, while past IVIM modeling studies have shown promise, they have also reported inconsistent results and limitations, underscoring the need to further enhance the accuracy of IVIM modeling for PCa detection. Therefore, this study utilized the control point registration toolbox function in MATLAB to fuse T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) MRI images with whole-mount pathology specimen images in order to eliminate potential bias in IVIM calculations. Sixteen PCa patients underwent prostate MRI scans before undergoing radical prostatectomies. The image fusion method was then applied in calculating the patients’ IVIM parameters. Furthermore, MRI scans were also performed on 22 healthy young volunteers in order to evaluate the changes in IVIM parameters with aging. Among the full study cohort, the f parameter was significantly increased with age, while the D* parameter was significantly decreased. Among the PCa patients, the D and ADC parameters could differentiate PCa tissue from contralateral normal tissue, while the f and D* parameters could not. The presented image fusion method also provided improved precision when comparing regions of interest side by side. However, further studies with more standardized methods are needed to further clarify the benefits of the presented approach and the different IVIM parameters in PCa characterization.

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