Unifying mechanism for anticancer agents involving electron transfer and oxidative stress: Clinical implications

2007 ◽  
Vol 69 (3) ◽  
pp. 510-516 ◽  
Author(s):  
Peter Kovacic
Keyword(s):  
Oxidative Stress ◽  
Electron Transfer ◽  
Anticancer Agents ◽  
Clinical Implications ◽  
And Oxidative Stress

scholarly journals Unifying Mechanism for Nutrients as Anticancer Agents: Electron Transfer, Reactive Oxygen Species and Oxidative Stress

2017 ◽  
Vol 9 (8) ◽  
pp. 66 ◽  
Author(s):  
Peter Kovacic ◽  
Ratnasamy Somanathan
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Electron Transfer ◽  
Anticancer Agents ◽  
Mode Of Action ◽  
Recent Article ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Bactericidal Action ◽  
And Oxidative Stress

A recent article deals with various nutrients in relation to bactericidal action. The present article focuses on a unifying mode of action for the nutrients, namely, resveratrol, epigallocatechin, polyene-ß-carotene, polyene lycopene, piperine, curcumin, genistein, luteolin, sulforaphane and pomegranate extract. The mechanism is based on electron transfer, reactive oxygen species and oxidative stress, which comprises an extension of earlier reports involving agents. Most of the compounds are precursors of electron transfer quinones, whereas others fit into the polyene category. The nutrients are better known as antioxidants. The dichotomy is addressed.

scholarly journals IMMUNE AGING AND SERIOUS CLINICAL IMPLICATIONS IN THE ELDERLY IN COVID-19

2021 ◽  
Vol 1 (5) ◽  
pp. e1553
Author(s):  
Eduardo Lopes Barbosa ◽  
Estéphany Miranda Dias ◽  
Letícia Lorem Vilhena de Castro ◽  
Maysa de Vasconcelos Brito
Keyword(s):  
Oxidative Stress ◽  
Intensive Care ◽  
Current Knowledge ◽  
The Elderly ◽  
Clinical Implications ◽  
Low Grade ◽  
Life Threatening ◽  
The Individual ◽  
T Cell Senescence ◽  
And Oxidative Stress

COVID-19, caused by SARS-CoV-2 infection, is mild to moderate in most healthy precedents, but can cause life-threatening illnesses or persistent debilitating symptoms in some cases. The severity of COVID-19 is related to age, with an obligation over 65 years of age, greater risk of needing intensive care. This is a descriptive, exploratory, integrative literature review, with the aim of explaining the current knowledge about the interference of the immunosenescence process in more severe conditions caused by covid-19 in the elderly. Aging is a systemic involution, including the immune system, affecting the individual with several comorbidities, including cardiac, pulmonary and neurological comorbidities that aggravate the situation of vulnerability. Aging is triggered by several mechanisms, among the most relevant are telomere reduction and oxidative stress, which in turn lead to other scenarios such as T-cell senescence, mitochondrial dysfunction and low-grade chronic inflammation, which are added to the mechanism of action of the virus that causes COVID-19, as its key-lock factor involving ACE-2, which has a change in expression during aging, portraying the interferences of this scenario, if not in contact with the major covid-19, which contributes to seriousness in the elderly .

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