Membrane adsorption of endocrine disrupting compounds and pharmaceutically active compounds

2007 ◽  
Vol 303 (1-2) ◽  
pp. 267-277 ◽  
Author(s):  
Anna M. Comerton ◽  
Robert C. Andrews ◽  
David M. Bagley ◽  
Paul Yang
Keyword(s):  
Endocrine Disrupting Compounds ◽  
Pharmaceutically Active Compounds ◽  
Active Compounds ◽  
Endocrine Disrupting

The impact of alum coagulation on pharmaceutically active compounds, endocrine disrupting compounds and natural organic matter

2013 ◽  
Vol 13 (5) ◽  
pp. 1348-1357 ◽  
Author(s):  
Sabrina Diemert ◽  
Robert C. Andrews
Keyword(s):  
Organic Matter ◽  
Organic Carbon ◽  
River Water ◽  
Natural Organic Matter ◽  
Endocrine Disrupting Compounds ◽  
Pharmaceutically Active Compounds ◽  
Active Compounds ◽  
Endocrine Disrupting ◽  
Grand River ◽  
The Impact

This study assessed the impact of chemical coagulation using alum on the removal of three endocrine-disrupting compounds (EDCs; bisphenol A, clofibric acid and estriol) and nine pharmaceutically active compounds (PhACs; acetaminophen, carbamazepine, diclofenac, gemfibrozil, ketoprofen, naproxen, pentoxifylline, sulfamethoxazole and sulfachloropyridazine). The impact on natural organic matter (NOM) fractions as determined using liquid chromatography–organic carbon detection (LC–OCD; total dissolved organic carbon (DOC), hydrophobic DOC, biopolymers, humic substances, building blocks, low molecular weight neutrals and acids) was also examined. Three test surface waters were included: Lake Ontario, Grand River and Otonabee River water (Ontario, Canada). Gemfibrozil concentrations were reduced in both Otonabee and Grand River waters. Reductions were noted for carbamazepine and (inconsistently) for acetaminophen, and estrone appeared to increase in concentration in Grand River water with increasing alum doses. NOM removal was primarily attributed to the humic fraction, with small reductions in biopolymers in all of the waters studied.

Application of Membrane Science to Remove Endocrine Disrupting Compounds (EDCs) and Pharmaceutically Active Compounds (PhACs): A Review

2014 ◽  
Vol 893 ◽  
pp. 500-503 ◽  
Author(s):  
Elnaz Halakoo ◽  
Javid Adabi ◽  
Sara Aalinezhad ◽  
Alireza Layeghi Moghaddam ◽  
Alireza Rahimi
Keyword(s):  
Endocrine Disrupting Compounds ◽  
Membrane Bioreactors ◽  
Membrane Technology ◽  
Pharmaceutically Active Compounds ◽  
High Quality ◽  
Water And Wastewater Treatment ◽  
Endocrine Disrupting ◽  
Water Quality Regulations ◽  
Major Factors ◽  
Membrane Science

To date, membrane technology is of great concern while conventional processes are not able to fulfill prosperous separation. The presence of EDCs in the environment indicates that conventional treatment plants (CTPs) may have limited capability to remove these compounds. Membrane process such as membrane bioreactors (MBRs), nanofiltration (NF) and reverse osmosis (RO) can produce high quality effluents suitable for reuse applications. Membrane bioreactor (MBR) technology is a promising method for water and wastewater treatment because of its ability to produce high-quality effluent that meets water quality regulations. This paper aimed to provide a review of recent research on feasibility of membrane technology such as MBR, NF and RO and also their application to remove EDCs and PhACs from aqueous solution which are highly harmful and toxic. The major factors which exert influence on the separation of these organic micropollutants have been also studied.

scholarly journals Estimation of the Mechanism of Adrenal Action of Endocrine-Disrupting Compounds Using a Computational Model of Adrenal Steroidogenesis in NCI-H295R Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-19 ◽  
Author(s):  
Ryuta Saito ◽  
Natsuko Terasaki ◽  
Makoto Yamazaki ◽  
Naoya Masutomi ◽  
Naohisa Tsutsui ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Cellular Proliferation ◽  
Endocrine Disrupting Compounds ◽  
Pharmaceutical Drugs ◽  
Active Compounds ◽  
Adrenal Steroidogenesis ◽  
Endocrine Disrupting ◽  
H295r Cells ◽  
Dynamic Sensitivity Analysis

Adrenal toxicity is one of the major concerns in drug development. To quantitatively understand the effect of endocrine-active compounds on adrenal steroidogenesis and to assess the human adrenal toxicity of novel pharmaceutical drugs, we developed a mathematical model of steroidogenesis in human adrenocortical carcinoma NCI-H295R cells. The model includes cellular proliferation, intracellular cholesterol translocation, diffusional transport of steroids, and metabolic pathways of adrenal steroidogenesis, which serially involve steroidogenic proteins and enzymes such as StAR, CYP11A1, CYP17A1, HSD3B2, CYP21A2, CYP11B1, CYP11B2, HSD17B3, and CYP19A1. It was reconstructed in an experimental dynamics of cholesterol and 14 steroids from anin vitrosteroidogenesis assay using NCI-H295R cells. Results of dynamic sensitivity analysis suggested that HSD3B2 plays the most important role in the metabolic balance of adrenal steroidogenesis. Based on differential metabolic profiling of 12 steroid hormones and 11 adrenal toxic compounds, we could estimate which steroidogenic enzymes were affected in this mathematical model. In terms of adrenal steroidogenic inhibitors, the predicted action sites were approximately matched to reported target enzymes. Thus, our computer-aided system based on systems biological approach may be useful to understand the mechanism of action of endocrine-active compounds and to assess the human adrenal toxicity of novel pharmaceutical drugs.

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