Rejection of neutral endocrine disrupting compounds (EDCs) and pharmaceutical active compounds (PhACs) by RO membranes

2004 ◽  
Vol 245 (1-2) ◽  
pp. 71-78 ◽  
Author(s):  
Katsuki Kimura ◽  
Shiho Toshima ◽  
Gary Amy ◽  
Yoshimasa Watanabe
Keyword(s):  
Endocrine Disrupting Compounds ◽  
Active Compounds ◽  
Endocrine Disrupting

Membrane adsorption of endocrine disrupting compounds and pharmaceutically active compounds

2007 ◽  
Vol 303 (1-2) ◽  
pp. 267-277 ◽  
Author(s):  
Anna M. Comerton ◽  
Robert C. Andrews ◽  
David M. Bagley ◽  
Paul Yang
Keyword(s):  
Endocrine Disrupting Compounds ◽  
Pharmaceutically Active Compounds ◽  
Active Compounds ◽  
Endocrine Disrupting

scholarly journals Estimation of the Mechanism of Adrenal Action of Endocrine-Disrupting Compounds Using a Computational Model of Adrenal Steroidogenesis in NCI-H295R Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-19 ◽  
Author(s):  
Ryuta Saito ◽  
Natsuko Terasaki ◽  
Makoto Yamazaki ◽  
Naoya Masutomi ◽  
Naohisa Tsutsui ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Cellular Proliferation ◽  
Endocrine Disrupting Compounds ◽  
Pharmaceutical Drugs ◽  
Active Compounds ◽  
Adrenal Steroidogenesis ◽  
Endocrine Disrupting ◽  
H295r Cells ◽  
Dynamic Sensitivity Analysis

Adrenal toxicity is one of the major concerns in drug development. To quantitatively understand the effect of endocrine-active compounds on adrenal steroidogenesis and to assess the human adrenal toxicity of novel pharmaceutical drugs, we developed a mathematical model of steroidogenesis in human adrenocortical carcinoma NCI-H295R cells. The model includes cellular proliferation, intracellular cholesterol translocation, diffusional transport of steroids, and metabolic pathways of adrenal steroidogenesis, which serially involve steroidogenic proteins and enzymes such as StAR, CYP11A1, CYP17A1, HSD3B2, CYP21A2, CYP11B1, CYP11B2, HSD17B3, and CYP19A1. It was reconstructed in an experimental dynamics of cholesterol and 14 steroids from anin vitrosteroidogenesis assay using NCI-H295R cells. Results of dynamic sensitivity analysis suggested that HSD3B2 plays the most important role in the metabolic balance of adrenal steroidogenesis. Based on differential metabolic profiling of 12 steroid hormones and 11 adrenal toxic compounds, we could estimate which steroidogenic enzymes were affected in this mathematical model. In terms of adrenal steroidogenic inhibitors, the predicted action sites were approximately matched to reported target enzymes. Thus, our computer-aided system based on systems biological approach may be useful to understand the mechanism of action of endocrine-active compounds and to assess the human adrenal toxicity of novel pharmaceutical drugs.

The impact of alum coagulation on pharmaceutically active compounds, endocrine disrupting compounds and natural organic matter

2013 ◽  
Vol 13 (5) ◽  
pp. 1348-1357 ◽  
Author(s):  
Sabrina Diemert ◽  
Robert C. Andrews
Keyword(s):  
Organic Matter ◽  
Organic Carbon ◽  
River Water ◽  
Natural Organic Matter ◽  
Endocrine Disrupting Compounds ◽  
Pharmaceutically Active Compounds ◽  
Active Compounds ◽  
Endocrine Disrupting ◽  
Grand River ◽  
The Impact

This study assessed the impact of chemical coagulation using alum on the removal of three endocrine-disrupting compounds (EDCs; bisphenol A, clofibric acid and estriol) and nine pharmaceutically active compounds (PhACs; acetaminophen, carbamazepine, diclofenac, gemfibrozil, ketoprofen, naproxen, pentoxifylline, sulfamethoxazole and sulfachloropyridazine). The impact on natural organic matter (NOM) fractions as determined using liquid chromatography–organic carbon detection (LC–OCD; total dissolved organic carbon (DOC), hydrophobic DOC, biopolymers, humic substances, building blocks, low molecular weight neutrals and acids) was also examined. Three test surface waters were included: Lake Ontario, Grand River and Otonabee River water (Ontario, Canada). Gemfibrozil concentrations were reduced in both Otonabee and Grand River waters. Reductions were noted for carbamazepine and (inconsistently) for acetaminophen, and estrone appeared to increase in concentration in Grand River water with increasing alum doses. NOM removal was primarily attributed to the humic fraction, with small reductions in biopolymers in all of the waters studied.

Nanofiltration of endocrine disrupting compounds

2003 ◽  
Vol 3 (5-6) ◽  
pp. 321-327 ◽  
Author(s):  
M. Gallenkemper ◽  
T. Wintgens ◽  
T. Melin
Keyword(s):  
Wastewater Treatment ◽  
Municipal Wastewater ◽  
Wastewater Treatment Plants ◽  
Endocrine Disrupting Compounds ◽  
Municipal Wastewater Treatment ◽  
Water And Wastewater Treatment ◽  
Wide Range ◽  
Endocrine Disrupting ◽  
Municipal Wastewater Treatment Plants ◽  
Set Up

Endocrine disrupting compounds can affect the hormone system in organisms. A wide range of endocrine disrupters were found in sewage and effluents of municipal wastewater treatment plants. Toxicological evaluations indicate that conventional wastewater treatment plants are not able to remove these substances sufficiently before disposing effluent into the environment. Membrane technology, which is proving to be an effective barrier to these substances, is the subject of this research. Nanofiltration provides high quality permeates in water and wastewater treatment. Eleven different nanofiltration membranes were tested in the laboratory set-up. The observed retention for nonylphenol (NP) and bisphenol A (BPA) ranged between 70% and 100%. The contact angle is an indicator for the hydrophobicity of a membrane, whose influence on the permeability and retention of NP was evident. The retention of BPA was found to be inversely proportional to the membrane permeability.

scholarly journals Effects of the Hedgehog signalling inhibitor itraconazole on developing rat ovaries

2021 ◽  
Author(s):  
Hanna Katarina Lilith Johansson ◽  
Camilla Taxvig ◽  
Gustav Peder Mohr Olsen ◽  
Terje Svingen
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting Compounds ◽  
Perinatal Period ◽  
Endocrine Function ◽  
Ovary Development ◽  
Knock Out ◽  
Female Reproductive Health ◽  
Endocrine Disrupting ◽  
Hh Signaling ◽  
Knock Out Mice

Abstract Early ovary development is considered to be largely hormone independent, yet there are associations between fetal exposure to endocrine disrupting chemicals and reproductive disorders in women. This can potentially be explained by perturbations to establishment of ovarian endocrine function rather than interference with an already established hormone system. In this study we explore if Hedgehog (HH) signaling, a central pathway for correct ovary development, can be disrupted by exposure to HH-disrupting chemicals, using the antifungal itraconazole as model compound. In the mouse Leydig cell line TM3, used as a proxy for ovarian theca cells, itraconazole exposure had a suppressing effect on genes downstream of HH signaling, such as Gli1. Exposing explanted rat ovaries (gestational day 22 or postnatal day 3) to 30 µM itraconazole for 72 h induced significant suppression of genes in the HH signaling pathway with altered Ihh, Gli1, Ptch1, and Smo expression similar to those previously observed in Ihh/Dhh knock-out mice. Exposing rat dams to 50 mg/kg bw/day in the perinatal period did not induce observable changes in the offspring’s ovaries. Overall, our results suggest that HH signal disruptors may affect ovary development with potential long-term consequences for female reproductive health. However, potent HH inhibitors would likely cause severe teratogenic effects at doses lower than those causing ovarian dysgenesis, so the concern with respect to reproductive disorder is for the presence of HH disruptors at low concentration in combination with other ovary or endocrine disrupting compounds.

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