Development of a hollow fiber membrane module for using implantable artificial lung

2009 ◽  
Vol 326 (1) ◽  
pp. 130-136 ◽  
Author(s):  
Gi-Beum Kim ◽  
Seong-Jong Kim ◽  
Min-Ho Kim ◽  
Chul-Un Hong ◽  
Hyung-Sub Kang
Keyword(s):  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Artificial Lung ◽  
Membrane Module ◽  
Fiber Membrane

scholarly journals A novel method for processing adipose-derived stromal stem cells using a closed cell washing concentration device with a hollow fiber membrane module

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Shinji Hayashi ◽  
Rieko Yagi ◽  
Shuhei Taniguchi ◽  
Masami Uji ◽  
Hidaka Urano ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Membrane Module ◽  
Fiber Membrane ◽  
Cell Processing ◽  
Closed Cell ◽  
A Cell ◽  
Novel Method ◽  
Stromal Stem Cells

AbstractCell-assisted lipotransfer (CAL) is an advanced lipoinjection method that uses autologous lipotransfer with addition of a stromal vascular fraction (SVF) containing adipose-derived stromal stem cells (ASCs). The CAL procedure of manual isolation of cells from fat requires cell processing to be performed in clean environment. To isolate cells from fat without the need for a cell processing center, such as in a procedure in an operation theater, we developed a novel method for processing SVF using a closed cell washing concentration device (CCD) with a hollow fiber membrane module. The CCD consists of a sterilized closed circuit, bags and hollow fiber, semi-automatic device and the device allows removal of >99.97% of collagenase from SVF while maintaining sterility. The number of nucleated cells, ASCs and viability in SVF processed by this method were equivalent to those in SVF processed using conventional manual isolation. Our results suggest that the CCD system is as reliable as manual isolation and may also be useful for CAL. This approach will help in the development of regenerative medicine at clinics without a cell processing center.

scholarly journals Applying a Hydrophilic Modified Hollow Fiber Membrane to Reduce Fouling in Artificial Lungs

Separations ◽  
2021 ◽  
Vol 8 (8) ◽  
pp. 113
Author(s):  
Nawaf Alshammari ◽  
Meshari Alazmi ◽  
Vajid Nettoor Veettil
Keyword(s):  
Gas Exchange ◽  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Membrane Surface ◽  
Artificial Lung ◽  
Hollow Fiber Membranes ◽  
Fiber Membrane ◽  
Hydrophilic Modification ◽  
Protein Fouling ◽  
Time Periods

Membranes for use in high gas exchange lung applications are riddled with fouling. The goal of this research is to create a membrane that can function in an artificial lung until the actual lung becomes available for the patient. The design of the artificial lung is based on new hollow fiber membranes (HFMs), due to which the current devices have short and limited periods of low fouling. By successfully modifying membranes with attached peptoids, low fouling can be achieved for longer periods of time. Hydrophilic modification of porous polysulfone (PSF) membranes can be achieved gradually by polydopamine (PSU-PDA) and peptoid (PSU-PDA-NMEG5). Polysulfone (PSU-BSA-35Mg), polysulfone polydopamine (PSUPDA-BSA-35Mg) and polysulfone polydopamine peptoid (PSU-PDA-NMEG5-BSA35Mg) were tested by potting into the new design of gas exchange modules. Both surfaces of the modified membranes were found to be highly resistant to protein fouling permanently. The use of different peptoids can facilitate optimization of the low fouling on the membrane surface, thereby allowing membranes to be run for significantly longer time periods than has been currently achieved.

Preparation of superoxide dismutase LIPOzyme in hollow fiber membrane module

2010 ◽  
Vol 17 (1-3) ◽  
pp. 281-287 ◽  
Author(s):  
Hiroyuki Sugaya ◽  
Hiroshi Umakoshi ◽  
K. B. M. A. Fadzil ◽  
Le Quoc Tuan ◽  
Toshinori Shimanouchi ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Membrane Module ◽  
Fiber Membrane

A New Multilayered Composite Hollow Fiber Membrane for Artificial Lung

1990 ◽  
Vol 14 (5) ◽  
pp. 369-372 ◽  
Author(s):  
Jun Kamo ◽  
Makoto Uchida ◽  
Takayuki Hirai ◽  
Haruhiko Yosida ◽  
Kensuke Kamada ◽  
...  
Keyword(s):  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Artificial Lung ◽  
Fiber Membrane ◽  
Multilayered Composite
Sign in / Sign up

Export Citation Format

Share Document