Water and salt transport properties of disulfonated poly(arylene ether sulfone) desalination membranes formed by solvent-free melt extrusion

2018 ◽  
Vol 546 ◽  
pp. 234-245 ◽  
Author(s):  
Hee Jeung Oh ◽  
James E. McGrath ◽  
Donald R. Paul
Keyword(s):  
Transport Properties ◽  
Solvent Free ◽  
Salt Transport ◽  
Melt Extrusion ◽  
Arylene Ether

Advances in membrane materials: desalination membranes based on directly copolymerized disulfonated poly(arylene ether sulfone) random copolymers

2010 ◽  
Vol 61 (3) ◽  
pp. 619-624 ◽  
Author(s):  
Wei Xie ◽  
Ho-Bum Park ◽  
Joseph Cook ◽  
Chang Hyun Lee ◽  
Gwangsu Byun ◽  
...  
Keyword(s):  
Transport Properties ◽  
Water Permeability ◽  
Salt Transport ◽  
Random Copolymers ◽  
Acid Form ◽  
Salt Form ◽  
Membrane Materials ◽  
Salt Rejection ◽  
Arylene Ether ◽  
Order Of Magnitude

The water and salt transport properties of chlorine tolerant disulfonated poly(arylene ether sulfone) (BPS) copolymers have been characterized. Cast BPS membranes of both salt form and acid form with sulfonation levels from 20% to 40% were investigated. Water permeability of BPS films increases more than one order of magnitude as sulfonation level increases from 20% to 40%, while the salt permeability of the corresponding membranes increases two orders of magnitude. Moderate salt rejection (98.2%) was achieved by a BPS salt form membrane with a sulfonation level of 20%.

Effect of Free Volume on Water and Salt Transport Properties in Directly Copolymerized Disulfonated Poly(arylene ether sulfone) Random Copolymers

2011 ◽  
Vol 44 (11) ◽  
pp. 4428-4438 ◽  
Author(s):  
Wei Xie ◽  
Hao Ju ◽  
Geoffrey M. Geise ◽  
Benny D. Freeman ◽  
James I. Mardel ◽  
...  
Keyword(s):  
Transport Properties ◽  
Free Volume ◽  
Salt Transport ◽  
Random Copolymers ◽  
Arylene Ether

scholarly journals Formation of disulfonated poly(arylene ether sulfone) thin film desalination membranes plasticized with poly(ethylene glycol) by solvent-free melt extrusion

Polymer ◽  
2017 ◽  
Vol 109 ◽  
pp. 106-114 ◽  
Author(s):  
Hee Jeung Oh ◽  
Jaesung Park ◽  
Sebnem Inceoglu ◽  
Irune Villaluenga ◽  
Jacob L. Thelen ◽  
...  
Keyword(s):  
Thin Film ◽  
Ethylene Glycol ◽  
Solvent Free ◽  
Poly Ethylene Glycol ◽  
Melt Extrusion ◽  
Arylene Ether ◽  
Poly Ethylene

Water and salt transport properties of zwitterionic polymers film

2015 ◽  
Vol 491 ◽  
pp. 73-81 ◽  
Author(s):  
Lei Ni ◽  
Jianqiang Meng ◽  
Geoffery M. Geise ◽  
Yufeng Zhang ◽  
Jin Zhou
Keyword(s):  
Transport Properties ◽  
Salt Transport ◽  
Zwitterionic Polymers

scholarly journals Development and Evaluation of Amorphous Oral Thin Films Using Solvent-Free Processes: Comparison between 3D Printing and Hot-Melt Extrusion Technologies

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1613
Author(s):  
Jiaxiang Zhang ◽  
Anqi Lu ◽  
Rishi Thakkar ◽  
Yu Zhang ◽  
Mohammed Maniruzzaman
Keyword(s):  
Thin Films ◽  
3D Printing ◽  
Drug Release ◽  
Hot Melt Extrusion ◽  
Dosage Forms ◽  
Solvent Free ◽  
Melt Extrusion ◽  
Physico Chemical ◽  
3D Printed ◽  
Hot Melt

Conventional oral dosage forms may not always be optimal especially for those patients suffering from dysphasia or difficulty swallowing. Development of suitable oral thin films (OTFs), therefore, can be an excellent alternative to conventional dosage forms for these patient groups. Hence, the main objective of the current investigation is to develop oral thin film (OTF) formulations using novel solvent-free approaches, including additive manufacturing (AM), hot-melt extrusion, and melt casting. AM, popularly recognized as 3D printing, has been widely utilized for on-demand and personalized formulation development in the pharmaceutical industry. Additionally, in general active pharmaceutical ingredients (APIs) are dissolved or dispersed in polymeric matrices to form amorphous solid dispersions (ASDs). In this study, acetaminophen (APAP) was selected as the model drug, and Klucel™ hydroxypropyl cellulose (HPC) E5 and Soluplus® were used as carrier matrices to form the OTFs. Amorphous OTFs were successfully manufactured by hot-melt extrusion and 3D printing technologies followed by comprehensive studies on the physico-chemical properties of the drug and developed OTFs. Advanced physico-chemical characterizations revealed the presence of amorphous drug in both HME and 3D printed films whereas some crystalline traces were visible in solvent and melt cast films. Moreover, advanced surface analysis conducted by Raman mapping confirmed a more homogenous distribution of amorphous drugs in 3D printed films compared to those prepared by other methods. A series of mathematical models were also used to describe drug release mechanisms from the developed OTFs. Moreover, the in vitro dissolution studies of the 3D printed films demonstrated an improved drug release performance compared to the melt cast or extruded films. This study suggested that HME combined with 3D printing can potentially improve the physical properties of formulations and produce OTFs with preferred qualities such as faster dissolution rate of drugs.

scholarly journals Hot-melt extrusion and prilling as contemporary and promising techniques in the solvent free production of solid oral dosage forms, based on solid dispersions

2016 ◽  
Vol 62 (1) ◽  
pp. 3-24 ◽  
Author(s):  
Aleksandar Aleksovski ◽  
Chris Vervaet ◽  
Rok Dreu
Keyword(s):  
Drug Delivery ◽  
Hot Melt Extrusion ◽  
Dosage Forms ◽  
Solvent Free ◽  
Oral Dosage ◽  
Drug Dissolution ◽  
Melt Extrusion ◽  
Solid Oral Dosage Forms ◽  
Oral Dosage Forms ◽  
Hot Melt

Hot melt extrusion and prilling are gaining importance as solvent free and continuous techniques in the production of solid oral dosage forms with added value, by incorporating active compound in a molten carrier which is further solidified to form solid dispersion. This article reviews these two techniques in terms of understanding process basics, equipment characteristics, required properties of processed materials and application of the processes for development of solid oral dosage forms. Studies revealed that both hot-melt extrusion and prilling are regarded as simple, robust and continuous methods for processing different types of materials and production of solid dosage forms based on solid matrices. However, understanding of their concepts and requirements together with careful material selection is crucial for stable material processing and obtaining stable products of high-quality. Hot-melt extrusion proved to be a suitable method for production of modified release dosage forms, taste masked dosage forms and dosage forms offering improved drug dissolution rate and solubility. Prilling till now has been successfully applied just in the production of multiple unit drug delivery systems for immediate and sustained drug delivery. Further studies on product development and process understanding are required for full implementation of prilling in the pharmaceutical field.

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