A novel role for zinc transporter 8 in the facilitation of zinc accumulation and regulation of testosterone synthesis in Leydig cells of human and mouse testicles

Metabolism ◽  
2018 ◽  
Vol 88 ◽  
pp. 40-50 ◽  
Author(s):  
Xiuli Zhang ◽  
Tingwen Guan ◽  
Boxuan Yang ◽  
Zhihong Chi ◽  
Zhan-You Wang ◽  
...  
Keyword(s):  
Leydig Cells ◽  
Zinc Transporter ◽  
Zinc Accumulation ◽  
Zinc Transporter 8 ◽  
Human And Mouse ◽  
Testosterone Synthesis

scholarly journals Kinetics of the Post-Onset Decline in Zinc Transporter 8 Autoantibodies in Type 1 Diabetic Human Subjects

2010 ◽  
Vol 95 (10) ◽  
pp. 4712-4719 ◽  
Author(s):  
J. M. Wenzlau ◽  
M. Walter ◽  
T. J. Gardner ◽  
L. M. Frisch ◽  
L. Yu ◽  
...  
Keyword(s):  
Human Subjects ◽  
Zinc Transporter ◽  
Zinc Transporter 8 ◽  
Kinetics Of ◽  
Post Onset

DWP6-2 Association between R325W zinc transporter-8 gene polymorphism (SLC30A8)and Type 2 diabetes

2008 ◽  
Vol 79 ◽  
pp. S29-S30
Author(s):  
Yong Ho Lee ◽  
Eun Seok Kang ◽  
So Hun Kim ◽  
Seung JinHan ◽  
Kyu Yeon Hur ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gene Polymorphism ◽  
Zinc Transporter ◽  
Zinc Transporter 8

Bridging-type enzyme-linked immunoassay for zinc transporter 8 autoantibody measurements in adult patients with diabetes mellitus

2015 ◽  
Vol 447 ◽  
pp. 90-95 ◽  
Author(s):  
Gareth Dunseath ◽  
Rossitza Ananieva-Jordanova ◽  
Rebecca Coles ◽  
Michael Powell ◽  
Marie Amoroso ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Zinc Transporter ◽  
Adult Patients ◽  
Zinc Transporter 8 ◽  
Patients With Diabetes

scholarly journals What has zinc transporter 8 autoimmunity taught us about type 1 diabetes?

Diabetologia ◽  
2019 ◽  
Vol 62 (11) ◽  
pp. 1969-1976 ◽  
Author(s):  
Claire L. Williams ◽  
Anna E. Long
Keyword(s):  
Type 1 Diabetes ◽  
Zinc Transporter ◽  
Zinc Transporter 8

Zearalenone perturbs the circadian clock and inhibits testosterone synthesis in mouse Leydig cells

2020 ◽  
Vol 84 (3) ◽  
pp. 112-124
Author(s):  
Lijia Zhao ◽  
Yaoyao Xiao ◽  
Cuimei Li ◽  
Jing Zhang ◽  
Yaojia Zhang ◽  
...  
Keyword(s):  
Circadian Clock ◽  
Leydig Cells ◽  
Testosterone Synthesis

scholarly journals A UNIQUE CASE OF ATEZOLIZUMAB-INDUCED AUTOIMMUNE DIABETES

2020 ◽  
Vol 6 (1) ◽  
pp. e30-e32
Author(s):  
Mimi Wong ◽  
Nirjhar Nandi ◽  
Ashim Sinha
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Autoimmune Diabetes ◽  
Case Reports ◽  
Zinc Transporter ◽  
Prior History ◽  
Unique Case ◽  
Cell Lung Carcinoma ◽  
Zinc Transporter 8 ◽  
First Case

Objective: Immunotherapy is a novel treatment that can cause autoimmune diabetes in rare cases. More cases occur following use of the inhibitor to the protein programmed cell death-1 rather than the inhibitor to programmed cell death-ligand 1. Methods: We report a unique case of autoimmune diabetes following atezolizumab use. Results: A 55-year-old, Aboriginal Australian female with no prior history of diabetes was commenced on atezolizumab for recurrent squamous cell lung carcinoma. Two months following its commencement, there was the onset of fatigue, polyuria, polydipsia, and new hyperglycemia. Subsequently she was found to have a borderline-low C peptide level of 0.6 nmol/L (reference range is 0.5 to 1.0 nmol/L), and positive zinc transporter-8 antibodies. Following the diagnosis of autoimmune diabetes, 5 units of glargine insulin was commenced which maintained euglycemia and resolved her symptoms of hyperglycemia. Conclusion: There are few case reports of atezolizumab-induced autoimmune diabetes. We present the first case associated with zinc transporter-8 antibodies, and a unique case of autoimmune diabetes in a patient of Aboriginal Australian background.

scholarly journals HC diet inhibited testosterone synthesis by activating endoplasmic reticulum stress in testicular Leydig cells

2019 ◽  
Vol 23 (5) ◽  
pp. 3140-3150 ◽  
Author(s):  
Chunxiao Yu ◽  
Fangjie Jiang ◽  
Meijie Zhang ◽  
Dandan Luo ◽  
Shanshan Shao ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Leydig Cells ◽  
Testosterone Synthesis
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