Porphyromonas gingivalis-mediated shedding of extracellular matrix metalloproteinase inducer (EMMPRIN) by oral epithelial cells: a potential role in inflammatory periodontal disease

2011 ◽  
Vol 13 (14-15) ◽  
pp. 1261-1269 ◽  
Author(s):  
Mark Feldman ◽  
Vu Dang La ◽  
Telma Blanca Lombardo Bedran ◽  
Denise Madalena Palomari Spolidorio ◽  
Daniel Grenier
Keyword(s):  
Extracellular Matrix ◽  
Epithelial Cells ◽  
Matrix Metalloproteinase ◽  
Periodontal Disease ◽  
Porphyromonas Gingivalis ◽  
Potential Role ◽  
Extracellular Matrix Metalloproteinase Inducer ◽  
Oral Epithelial Cells ◽  
Oral Epithelial

scholarly journals Potential role of high molecular weight hyaluronan in the anti-Candidaactivity of human oral epithelial cells

2007 ◽  
Vol 45 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Akiyoshi Sakai ◽  
Sumio Akifusa ◽  
Naoki Itano ◽  
Koji Kimata ◽  
Taro Kawamura ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Epithelial Cells ◽  
High Molecular Weight ◽  
Potential Role ◽  
Oral Epithelial Cells ◽  
Oral Epithelial

scholarly journals Identification of bistable populations of Porphyromonas gingivalis that differ in epithelial cell invasion

Microbiology ◽  
2010 ◽  
Vol 156 (10) ◽  
pp. 3052-3064 ◽  
Author(s):  
S. Suwannakul ◽  
G. P. Stafford ◽  
S. A. Whawell ◽  
C. W. I. Douglas
Keyword(s):  
Epithelial Cells ◽  
Porphyromonas Gingivalis ◽  
Cell Invasion ◽  
Protease Activity ◽  
Periodontal Pathogen ◽  
Wild Type ◽  
Oral Epithelial Cells ◽  
Specific Protease ◽  
Oral Epithelial ◽  
First Time

Bistable populations of bacteria give rise to two or more subtypes that exhibit different phenotypes. We have explored whether the periodontal pathogen Porphyromonas gingivalis exhibits bistable invasive phenotypes. Using a modified cell invasion assay, we show for the first time that there are two distinct subtypes within a population of P. gingivalis strains NCTC 11834 and W50 that display differences in their ability to invade oral epithelial cells. The highly invasive subtype invades cells at 10–30-fold higher levels than the poorly invasive subtype and remains highly invasive for approximately 12–16 generations. Analysis of the gingipain activity of these subtypes revealed that the highly invasive type had reduced cell-associated arginine-specific protease activity. The role of Arg-gingipain activity in invasion was verified by enhancement of invasion by rgpAB mutations and by inclusion of an Arg-gingipain inhibitor in invasion assays using wild-type bacteria. In addition, a population of ΔrgpAB bacteria did not contain a hyperinvasive subtype. Screening of the protease activity of wild-type populations of both strains identified high and low protease subtypes which also showed a corresponding reduction or enhancement, respectively, of invasive capabilities. Microarray analysis of these bistable populations revealed a putative signature set of genes that includes oxidative stress resistance and iron transport genes, and which might be critical to invasion of or survival within epithelial cells.

scholarly journals A role for fimbriae in Porphyromonas gingivalis invasion of oral epithelial cells.

1997 ◽  
Vol 65 (5) ◽  
pp. 1980-1984 ◽  
Author(s):  
T Njoroge ◽  
R J Genco ◽  
H T Sojar ◽  
N Hamada ◽  
C A Genco
Keyword(s):  
Epithelial Cells ◽  
Porphyromonas Gingivalis ◽  
Oral Epithelial Cells ◽  
Oral Epithelial

Potential role of Candida albicans secreted aspartic protease 9 in serum induced-hyphal formation and interaction with oral epithelial cells

2020 ◽  
Vol 139 ◽  
pp. 103896
Author(s):  
Haiping Yang ◽  
Peter Chiu Shun Tsang ◽  
Edmond Ho Nang Pow ◽  
Otto Lok Tao Lam ◽  
Paul Wai-Kei Tsang
Keyword(s):  
Candida Albicans ◽  
Epithelial Cells ◽  
Potential Role ◽  
Aspartic Protease ◽  
Oral Epithelial Cells ◽  
Hyphal Formation ◽  
Oral Epithelial
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