Safety and efficacy of herbal remedies in obstetrics—review and clinical implications

Midwifery ◽  
2011 ◽  
Vol 27 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Lone Holst ◽  
David Wright ◽  
Svein Haavik ◽  
Hedvig Nordeng
Keyword(s):  
Herbal Remedies ◽  
Clinical Implications ◽  
Safety And Efficacy

Ladder of life of a modern woman: how to maintain health. Opportunities and prospects of phytotherapy (to help a practitioner)

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (2) ◽  
pp. 12-17 ◽  
Author(s):  
Vera N Prilepskaya ◽  
Elena G Nazarenko
Keyword(s):  
Reproductive System ◽  
Premenstrual Syndrome ◽  
Herbal Remedies ◽  
Herbal Therapy ◽  
Menopausal Syndrome ◽  
Safety And Efficacy ◽  
Modern View ◽  
Pathological Conditions

The article provides a modern view on features of different stages of a woman’s life. It presents information on pathogenetic basis and effectiveness of modern phytotherapy with a use of certified agents for a treatment of main pathological conditions associated with different stages of a woman’s life when the hypothalamic-pituitary-ovarian system’s function is formed, actively functions and then undergoes a gradual involution. The features of the use of herbal remedies in pathological conditions of the reproductive system (premenstrual syndrome, hyperprolactinemia, menopausal syndrome, mastalgia, etc.) are described. The article is illustrated with figures and tables for better understanding by clinicians. It emphasis on the features of herbal therapy, its high acceptability, safety and efficacy in the age aspect.

Herbal Remedies and Children: Do They Work? Are They Harmful?

PEDIATRICS ◽  
2003 ◽  
Vol 112 (Supplement_1) ◽  
pp. 240-246 ◽  
Author(s):  
Alan D. Woolf
Keyword(s):  
Primary Care ◽  
Herbal Medicine ◽  
Herbal Medicines ◽  
Good Health ◽  
Herbal Remedies ◽  
Herbal Products ◽  
Safety And Efficacy ◽  
Primary Care Clinicians

More parents are considering the use of herbal remedies to maintain their children’s good health and to treat their illnesses. They look to pediatricians and other primary care clinicians for advice concerning the safety and efficacy of herbal products for children. This article reviews principles for the clinician to keep in mind while investigating the literature on herbal medicine and addressing the use of herbal medicines with parents.

Product Associated Variation in Generic Enoxaparin. Potential Clinical Implications

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 1249-1249
Author(s):  
Jawed Fareed ◽  
Debra Hoppensteadt ◽  
Albara Ottman ◽  
Omer Iqbal ◽  
Walter Jeske ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Conflicts Of Interest ◽  
Generic Product ◽  
Clinical Implications ◽  
Similar Distribution ◽  
Thrombin Time ◽  
Distribution Profile ◽  
Molecular Weight Range ◽  
Safety And Efficacy ◽  
Generic Products

Abstract Abstract 1249 Recently the generic versions of enoxaparin brand (Sanofi-Aventis) have widely become available. Since enoxaparin is a biological product, minor compositional changes in these agents may potentially have clinical implications. Generic enoxaparins are manufactured by several companies and marketed under specific trade names. The purpose of this investigation was to determine the differences between generic products and within product variations in the same generic product. Eight generic products from India (Cutenox, Markaparin, Clenox, Lomoparin, Lupenox, Lomorin-NX, Lomoh-40 and Troynoxa-40), four generic products from South America (Enoxalow, Versa, Heptron and Endocris), and one generic product from the USA (Enoxaparin sodium) were studied. The molecular weight profile of generic products showed relatively similar distribution profile with a molecular weight range of 3.9–4.9 kDa. The anti-FXa activity ranged from 87–110 U/mg, whereas wider variations were noted in anti-FIIa activity (28–41 U/mg). The anti-FXa:anti-FIIa ratio ranged from 3.1–4.2. Much wider variations (up to 60%) were noted in the anticoagulant assays (ACT, aPTT, Heptest, and thrombin time). Additionally the generic products also showed variations in the thrombin generation assay. Protamine and PF4 titration profile also showed variations. AT mediated inhibition of thrombin and FXa in the biochemical assays showed wider differences in IC50 values. Heparinase digestion profile showed variable oligosaccharide composition and some of the products contained heparinase resistant glycosaminoglycans. A comparison of 5 batches of the branded enoxaparin (Clexane) and 5 batches of a generic enoxaparin showed that the generic product batches exhibited greater variation in the biologic assays despite a comparable anti-FXa profile. These observations suggest that despite the current regulatory requirements, product based differences in the generic enoxaparins exist, which may impact their safety and efficacy profile in cardiovascular and thrombotic indications for which the branded enoxaparin is approved. Additional pharmacodynamic studies and clinical validations of the safety and efficacy of each of the generic products maybe helpful in assuring a clinical equivalence of the generic products with the branded enoxaparin. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Biosimilars in Inflammatory Bowel Diseases: General Concepts and Clinical Implications

2021 ◽  
Author(s):  
Sabrina Rodrigues de Figueiredo ◽  
Ana Elisa Rabe Caon ◽  
Rogerio Saad Hossne ◽  
Fábio Vieira Teixeira ◽  
Sabine Murakami Winkler ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Clinical Implications ◽  
Safety And Efficacy ◽  
Therapeutic Goals ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Reducing Costs ◽  
The Cost ◽  
Over Time

The treatment of inflammatory bowel disease (IBD) has changed over time with the increasing use of biologics to achieve therapeutic goals. As a result, the cost of treatment increased considerably, making it necessary to develop strategies that could increase access to biological therapies. In this scenario, the biosimilars were developed with the aim of reducing costs, maintaining safety and efficacy compared to the originator. Initially, its use in IBD was based on the extrapolation of studies in other specialties, such as rheumatology. More recently, studies in inflammatory bowel disease have emerged, with favorable results for its use. It is known that there are still knowledge gaps in the use of biosimilars and more experience is needed to increase clinicians’ confidence in their clinical practice. This chapter proposes a review of what is currently known about biosimilars in IBD. It discusses about aspects such as safety, efficacy, interchangeability, immunogenicity and switches.

scholarly journals Surgery and Herbal Therapy: Essential Guidelines on Bleeding, Skin Reactions, and Wound Healing

2000 ◽  
Vol 6 (1) ◽  
pp. 29-40 ◽  
Author(s):  
Edmund deAzevedo Pribitkin ◽  
Gregory Boger
Keyword(s):  
Wound Healing ◽  
Aloe Vera ◽  
Herbal Medicines ◽  
Herbal Remedies ◽  
Herbal Therapy ◽  
Skin Reactions ◽  
Safety And Efficacy ◽  
Risk Of Bleeding ◽  
Aloe Vera Gel ◽  
Herbal Therapies

Unlike other forms of complementary and alternative medicine (CAM), herbal medi cine (phytomedicine) employs remedies possessing significant pharmacological activ ity and consequently potential adverse effects and drug interactions. The explosion in sales of herbal therapies has brought many products to the marketplace that do not conform to the standards of safety and efficacy that physicians and patients expect. Unfortunately, few surgeons question patients regarding their use of herbal medicines, and 70% of patients do not reveal their use of herbal medicines to their physicians and pharmacists (Eisenberg et al., 1993). All surgeons should question patients regarding the use of the following common herbal remedies, which may increase the risk of bleeding during surgical procedures: feverfew, garlic, ginger, gingko, Asian ginseng. Conversely, surgeons may employ herbal medicines such as aloe vera gel to aid in wound healing. When prescribing herbal medicines, practitioners are advised to select manufacturers who adhere to the code of pharmaceutical Good Manufacturing Process.

scholarly journals The Use of Plant Origin Remedies in Children with ARVI

2018 ◽  
Vol 17 (4) ◽  
pp. 43-45
Author(s):  
O. V. Shamsheva
Keyword(s):  
Respiratory Diseases ◽  
Scientific Literature ◽  
Respiratory Infections ◽  
Biologically Active ◽  
Herbal Remedies ◽  
Symptomatic Therapy ◽  
Plant Origin ◽  
Clinical Safety ◽  
Safety And Efficacy ◽  
Proven Efficacy

The analysis of the scientific literature and the results of clinical studies on the safety and efficacy of using for respiratory infections components of plant origin and bee products included in the composition of biologically active food supplements — «Propolis with Herbs» marmalade, throat lollipop with honey and Althaea night syrup with honey-line INVAR KIDS. It has been shown that the use of herbal remedies that contain components with established clinical safety and proven efficacy as a symptomatic therapy is reasonable for alleviating the main symptoms of respiratory diseases in children.

Effects of Selected Rhinologic Disorders on the Perception of Nasal Resonance in Children

1984 ◽  
Vol 15 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Michael P. Rastatter ◽  
Melvin Hyman
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Implications ◽  
Normal Children ◽  
Nasal Resonance

A group of sophisticated listeners judged the nasal resonance characteristics of normal children versus children evidencing selected rhinologic disorders under three speaking conditions. Results showed that perceptions of denasality are influenced by both speakers and speaking tasks. That is, children with allergic rhinitis and edemic adenoids were perceived as being denasal when they produced VCV utterances and recited sentences. However, their resonance characteristics were deemed normal for vowel productions. Interestingly, children with severely deviated septums were judged to have normal nasal resonance under all speaking conditions. Clinical implications are discussed.

Perceptions of Stuttering of Different Age Groups

2019 ◽  
Vol 4 (6) ◽  
pp. 1311-1315
Author(s):  
Sergey M. Kondrashov ◽  
John A. Tetnowski
Keyword(s):  
Age Groups ◽  
School Age Children ◽  
Clinical Implications ◽  
School Age ◽  
Fourth Edition ◽  
Self Perception ◽  
Behavioral Measures ◽  
Self Rating ◽  
Comparison Results ◽  
Subject Pool

Purpose The purpose of this study was to assess the perceptions of stuttering of school-age children who stutter and those of adults who stutter through the use of the same tools that could be commonly used by clinicians. Method Twenty-three participants across various ages and stuttering severity were administered both the Stuttering Severity Instrument–Fourth Edition (SSI-4; Riley, 2009 ) and the Wright & Ayre Stuttering Self-Rating Profile ( Wright & Ayre, 2000 ). Comparisons were made between severity of behavioral measures of stuttering made by the SSI-4 and by age (child/adult). Results Significant differences were obtained for the age comparison but not for the severity comparison. Results are explained in terms of the correlation between severity equivalents of the SSI-4 and the Wright & Ayre Stuttering Self-Rating Profile scores, with clinical implications justifying multi-aspect assessment. Conclusions Clinical implications indicate that self-perception and impact of stuttering must not be assumed and should be evaluated for individual participants. Research implications include further study with a larger subject pool and various levels of stuttering severity.

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