Novel cationic surfactants with cleavable carbamate fragment: Tunable morphological behavior, solubilization of hydrophobic drugs and cellular uptake study

2020 ◽  
Vol 318 ◽  
pp. 113894 ◽  
Author(s):  
Rushana A. Kushnazarova ◽  
Alla B. Mirgorodskaya ◽  
Svetlana S. Lukashenko ◽  
Alexandra D. Voloshina ◽  
Anastasiia S. Sapunova ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Cationic Surfactants ◽  
Hydrophobic Drugs ◽  
Uptake Study ◽  
Morphological Behavior

scholarly journals Protein-Coated Aryl Modified Gold Nanoparticles for Cellular Uptake Study by Osteosarcoma Cancer Cells

2020 ◽  
Author(s):  
Mehvesh Hameed ◽  
Seema Panicker ◽  
Sallam Hasan Abdallah ◽  
Amir A. Khan ◽  
Changseok Han ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Phase Transfer ◽  
Chemical Reduction ◽  
Uptake Study ◽  
Stabilizing Agents ◽  
Coated Nanoparticles ◽  
Green Route ◽  
The Difference

We synthesized protein-coated gold nanoparticles using green and chemical reduction routes for cellular uptake study. In the current work, we coated gold-aryl nanoparticles of the type AuNPs-C<sub>6</sub>H<sub>4</sub>-4-COOH with BSA, collagen, zein and lysozyme proteins. Both routes were carried out without phase-transfer catalysts or extraneous stabilizing agents. High crystallinity of the AuNPs synthesized by the green route can be seen in the transmission electron microscopy images. <a>Osteosarcoma cancer cells are malignant bone tumors with abnormal cellular functions. Studies using MG-63 cells will provide mechanistic suggestions on the details of the amplification in tumors. </a>We studied the cellular uptake of the bioconjugates by MG-63 osteosarcoma cells using laser confocal fluorescence microscopy (LCFM) and flow cytometry. In the LCFM study, BSA-AuNPs was uptaken most efficiently of all protein-coated gold nanoparticles synthesized by the green route. Zein and lysozyme coated nanoparticles, though small sizes, prepared by the green method were not efficiently uptaken by MG-63. The two nanoparticles are negatively charged and zein is also a hydrophobic coat. The difference in hydrophobicity and charge might have affected the internalization. All of those coated nanoparticles that were efficiently uptaken can potentially be used as diagnostic and therapeutic agents for osteosarcoma.

Dextran-pegylated microparticles for enhanced cellular uptake of hydrophobic drugs

2013 ◽  
Vol 84 (3) ◽  
pp. 540-548 ◽  
Author(s):  
Roberta Cassano ◽  
Teresa Ferrarelli ◽  
Andreas G. Schätzlein ◽  
Ijeoma F. Uchegbu ◽  
Sonia Trombino
Keyword(s):  
Cellular Uptake ◽  
Hydrophobic Drugs

scholarly journals Evaluation of Chitosan-Tripolyphosphate Nanoparticles as a p-shRNA Delivery Vector: Formulation, Optimization and Cellular Uptake Study

2013 ◽  
Vol 1 (3) ◽  
pp. 266-278 ◽  
Author(s):  
Mahdi Karimi ◽  
Pinar Avci ◽  
Mohsen Ahi ◽  
Tarane Gazori ◽  
Michael R. Hamblin ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Uptake Study ◽  
Formulation Optimization ◽  
Delivery Vector

scholarly journals Protein-Coated Aryl Modified Gold Nanoparticles for Cellular Uptake Study by Osteosarcoma Cancer Cells

Langmuir ◽  
2020 ◽  
Vol 36 (40) ◽  
pp. 11765-11775
Author(s):  
Mehavesh Hameed ◽  
Seema Panicker ◽  
Sallam H. Abdallah ◽  
Amir A. Khan ◽  
Changseok Han ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Uptake Study

PEGYLATED PAMAM ENCAPSULATED FREE-CD QUANTUM DOTS AND THEIR CELLULAR UPTAKE STUDY

2018 ◽  
Vol 26 (1) ◽  
pp. 51-58
Author(s):  
Norhidayah Abu ◽  
◽  
Azreena Mastor ◽  
Siti Farhana Hisham ◽  
Nurhaslina Johari ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Cellular Uptake ◽  
Uptake Study
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