Double w/o/w self-nano emulsifying drug delivery system of imatinib mesylate for colon cancer treatment

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Đorđe Cvjetinović ◽  
Željko Prijović ◽  
Drina Janković ◽  
Magdalena Radović ◽  
Marija Mirković ◽  
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pp. 668-688 ◽  
Author(s):  
N.M. Salkho ◽  
R.Z. Turki ◽  
O. Guessoum ◽  
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Tao Yuan ◽  
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Dose-Response ◽  
2020 ◽  
Vol 18 (2) ◽  
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Chuan Xie ◽  
Yan Zhan ◽  
Peng Wang ◽  
Bo Zhang ◽  
Yukun Zhang

Adipic dihydrazide and heparin were attached to ZnO quantum dots surface, and the ZnO-adipic dihydrazide-heparin nanocomplex was used as a drug delivery system to deliver paclitaxel for chemotherapy. The surface modification and the loading of paclitaxel were confirmed by Fourier transform infrared spectrum, featured by characteristic peaks from functional groups of adipic dihydrazide, heparin, and paclitaxel. The impacts of pH on the drug release were investigated, and the cytotoxicity studies were conducted with A549 cells. The pharmacokinetic study was conducted with male Wistar rats. Both in vitro and in vivo study indicated that ZnO-adipic dihydrazide-heparin-paclitaxel nanocomplex could deliver paclitaxel in a more controllable way, and it has the potential to be a high-efficiency drug delivery system for cancer treatment.


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