Influence of polyethylene glycol (PEG) chain length on the thermal behavior of spin-coated thin films of biodegradable poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/PEG blends

Abstract The second main cause of death in the world and one of the major public health problems is cancer. Curcumin is anatural bioactive substance with good anti-cancerous effect.However, due to thelow cellular uptake of curcumin anti-cancer drug, it is vital to exploit a noble formulation, which can contribute to a decrease in its hydrophobicity and enables theefficient therapeutic effect of curcumin. Biocompatibility and hydrophilicity of the polyethylene glycol cause itto be one of the most attractive drug carriers. Chitosan is also of great importance, consideringits biocompatibility,and is used along with thedrug-carrying polymers. In this study, for the first time, a combination oftrimethyl chitosan and polyethylene glycol was employedto deliver curcumin.Herein, hydrophilicity, stability, and energy analysis of the systems have been investigated, from which it was found thatthe 60/40 is the optimum ratio concentration ofchitosan to polyethylene glycol for Curcumin delivery. Another characteristic property of the hybrid drug delivery system was the PEG chain length, with its least magnitude being the optimal value. Results of the present molecular study give a practicalinsight into the curcumin drug delivery system and propose a novel hybrid carrier for efficient curcumin delivery, which can be further exploited to develop novel nanomedicine systems.

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Revealing thermal behavior of poly(3-hydroxybutyrate- co -3-hydroxyhexanoate) and its polyethylene glycol blends thin films: Effect of 3-Hydroxyhexanoate comonomer content

Journal of Molecular Structure ◽

10.1016/j.molstruc.2018.02.053 ◽

2018 ◽

Vol 1162 ◽

pp. 140-144 ◽

Cited By ~ 3

Author(s):

Yujing Chen ◽

Isao Noda ◽

Young Mee Jung

Keyword(s):

Thin Films ◽

Polyethylene Glycol ◽

Thermal Behavior ◽

Comonomer Content

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The polyethylene glycol xanthate-mediated synthesis of block copolymers via novel MADIX agents containing azo initiator: Effect of PEG chain length on molecular properties

Polymer Bulletin ◽

10.1007/s00289-021-03813-8 ◽

2021 ◽

Author(s):

Umit Yildiko ◽

Ahmet Cagri Ata ◽

İsmail Cakmak ◽

Aslihan Aycan Tanriverdi

Keyword(s):

Polyethylene Glycol ◽

Block Copolymers ◽

Chain Length ◽

Molecular Properties ◽

Initiator Effect ◽

Azo Initiator ◽

Peg Chain Length

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The effects of choice of anion (X=C1−, SCN−, NO3−) and polyethylene glycol (PEG) chain length on the local and supramolecular structures of LnX3/PEG complexes

Journal of Alloys and Compounds ◽

10.1016/s0925-8388(96)02640-0 ◽

1997 ◽

Vol 249 (1-2) ◽

pp. 41-48 ◽

Cited By ~ 40

Author(s):

Robin D. Rogers ◽

Jianhua Zhang ◽

Cary B. Bauer

Keyword(s):

Polyethylene Glycol ◽

Chain Length ◽

Supramolecular Structures ◽

Peg Chain Length

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Impact of Chain Length on Release Behavior of Modified Polyethylene Glycol Intercalated-Montmorillonite Nanocomposite

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2020.17860 ◽

2020 ◽

Vol 20 (9) ◽

pp. 5546-5554

Author(s):

Mosaed Al-Sahly ◽

Hany El-Hamshary ◽

Salem S. Al-Deyab

Keyword(s):

Electron Microscopy ◽

Polyethylene Glycol ◽

Ion Exchange ◽

Chain Length ◽

Fickian Diffusion ◽

Release Behavior ◽

Molecular Weights ◽

Peg 4000 ◽

Model Drug ◽

Peg Chain Length

A new drug delivery nanocomposite system was prepared from sodium montmorillonite (Na+Mt) intercalated with modified polyethylene glycol (PEG). PEGs of different molecular weights (400, 4000, and 8000) were modified with glycidyltrimethylammonium chloride (GTMAC) to provide terminal quaternary ammonium sites capable for attaching with Mt or other materials through ion exchange. The modified PEG-GTMAC derivatives were reacted in excess amount with Na+Mt through ion exchange. The remaining quaternary sites were used for the attachment of sodium diclofenac as a model drug. The structures of the prepared clay-modified PEG-diclofenac systems were characterized using Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The release behavior of diclofenac from the different nanocomposites was studied at different pH values. With regard to the PEG chain length, the drug release increased with increasing PEG molecular weight (GCDIII > GCD-III > GCDII > GCDI). The kinetics of the release models was discussed using Korsmeyer–Peppas, Higuchi, and zero- and first-order models. The results of the kinetics study revealed that modified samples with PEG 400 and PEG 4000 (GCD-I and GCDII) exhibited non-Fickian diffusion (anomalous transport) while modified samples with PEG 8000 (GCDIII) exhibited super case-II transport.

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