Abstract
The second main cause of death in the world and one of the major public health problems is cancer. Curcumin is anatural bioactive substance with good anti-cancerous effect.However, due to thelow cellular uptake of curcumin anti-cancer drug, it is vital to exploit a noble formulation, which can contribute to a decrease in its hydrophobicity and enables theefficient therapeutic effect of curcumin. Biocompatibility and hydrophilicity of the polyethylene glycol cause itto be one of the most attractive drug carriers. Chitosan is also of great importance, consideringits biocompatibility,and is used along with thedrug-carrying polymers. In this study, for the first time, a combination oftrimethyl chitosan and polyethylene glycol was employedto deliver curcumin.Herein, hydrophilicity, stability, and energy analysis of the systems have been investigated, from which it was found thatthe 60/40 is the optimum ratio concentration ofchitosan to polyethylene glycol for Curcumin delivery. Another characteristic property of the hybrid drug delivery system was the PEG chain length, with its least magnitude being the optimal value. Results of the present molecular study give a practicalinsight into the curcumin drug delivery system and propose a novel hybrid carrier for efficient curcumin delivery, which can be further exploited to develop novel nanomedicine systems.
The effect of the polyethylene glycol chain length of a lipopolymer (DSPE-PEGn) on the properties of DPPC monolayers and bilayers