Facile synthesis, X-Ray structure of new multi-substituted aryl imidazole ligand, biological screening and DNA binding of its Cr(III), Fe(III) and Cu(II) coordination compounds as potential antibiotic and anticancer drugs

The development of a few worldwide routinely used Pt(II) coordination compounds is described from a mechanistic point of view and related to the molecular aspects of Pt-DNA binding. Mechanistic knowledge developed from these studies is applied nowadays for the design and synthesis of new bifunctional and trifunctional compounds, aimed for use as improved anticancer drugs.

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MOLECULAR AND ELECTRONIC STRUCTURE OF HYDROLIZED PLATINUM ANTICANCER DRUGS REVEALED BY X-RAY ABSORPTION, IR, UV-VIS SPECTROSCOPIES AND DFT CALCULATIONS

Журнал структурной химии ◽

10.15372/jsc20160724 ◽

2016 ◽

Keyword(s):

Electronic Structure ◽

Dft Calculations ◽

Anticancer Drugs ◽

X Ray ◽

Platinum Anticancer Drugs ◽

X Ray Absorption ◽

Molecular And Electronic Structure

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Discovery of DNA Binding Anticancer Drugs That Target Oncogenic Transcription Factors Associated With Human Breast Cancer

10.21236/ada403322 ◽

2001 ◽

Author(s):

Terry A. Beerman

Keyword(s):

Breast Cancer ◽

Transcription Factors ◽

Dna Binding ◽

Anticancer Drugs ◽

Human Breast Cancer ◽

Human Breast ◽

Factors Associated

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Facile synthesis of aminoalkyl naphthols and single crystal X-ray, computational studies on 1-[morpholino(thiophen-2-yl)methyl]naphthalen-2-ol

Journal of Molecular Structure ◽

10.1016/j.molstruc.2021.130861 ◽

2021 ◽

pp. 130861

Author(s):

C.P. Surya ◽

G. Harichandran ◽

S. Muthu

Keyword(s):

Single Crystal ◽

Computational Studies ◽

Facile Synthesis ◽

X Ray

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Facile synthesis of 2D nanoflakes and 3D nanosponge-like Ni1−xO via direct calcination of Ni (II) coordination compounds of imidazole and 4-nitrobenzoate: Adsorptive separation kinetics and photocatalytic removal of Amaranth dye contaminated wastewater

Journal of Molecular Liquids ◽

10.1016/j.molliq.2020.115235 ◽

2020 ◽

pp. 115235

Author(s):

Amarja P. Naik ◽

Jyoti V. Sawant ◽

Hemant Mittal ◽

Ali Al Alili ◽

Pranay P. Morajkar

Keyword(s):

Coordination Compounds ◽

Facile Synthesis ◽

Adsorptive Separation ◽

Photocatalytic Removal ◽

Separation Kinetics

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Facile synthesis, DNA binding, Urease inhibition, anti-oxidant, molecular docking and DFT studies of 3-(3-Bromo-phenyl)-1-(2-trifluoromethyl-phenyl)-propenone and 3-(3-Bromo-5 chloro-phenyl)-1-(2-trifluoromethyl-phenyl)-propenone

Journal of Molecular Liquids ◽

10.1016/j.molliq.2021.116302 ◽

2021 ◽

pp. 116302

Author(s):

Faiz Rasool ◽

Muhammad Khalid ◽

Muhammad Yar ◽

Khurshid Ayub ◽

Muhammad Tariq ◽

...

Keyword(s):

Molecular Docking ◽

Dna Binding ◽

Urease Inhibition ◽

Dft Studies ◽

Facile Synthesis ◽

Anti Oxidant

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A new one-pot three-component synthesis of 4-aryl-6-cycloamino-1,3,5-triazin-2-amines under microwave irradiation

Synthesis ◽

10.1055/a-1401-2795 ◽

2021 ◽

Author(s):

Muhammad Syafiq Bin Shahari ◽

Ahmad Junaid ◽

Edward R. T. Tiekink ◽

Anton V. Dolzhenko

Keyword(s):

Microwave Irradiation ◽

Aromatic Aldehydes ◽

Antileukemic Activity ◽

One Pot ◽

Biological Screening ◽

X Ray ◽

X Ray Crystallography ◽

Cyclic Amines ◽

Three Component Reaction ◽

Fast Synthesis

A new method for the fast synthesis of diverse 4-aryl-6-cycloamino-1,3,5-triazin-2-amines was developed. The synthesis is performed under microwave irradiation in a one-pot manner from cyanoguanidine, aromatic aldehydes, and cyclic amines. Their three-component reaction in the presence of hydrochloric acid produced dihydrotriazines, which were then converted (without isolation) to the targeted compounds via aromatic dehydrogenation in the presence of alkali. The reaction tolerated various aromatic aldehydes (including heterocyclic) and cyclic amines. Crystal structures of two representative 4-aryl-6-morpholino-1,3,5-triazin-2-amines were established by X-ray crystallography. The results of preliminary biological screening identified potent antileukemic activity for 6-(3,4-dihydroisoquinolin-2(1<i>H</i>)-yl)-4-phenyl-1,3,5-triazin-2-amine.

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