Discovery of DNA Binding Anticancer Drugs That Target Oncogenic Transcription Factors Associated With Human Breast Cancer

2001 ◽  
Author(s):  
Terry A. Beerman
Keyword(s):  
Breast Cancer ◽  
Transcription Factors ◽  
Dna Binding ◽  
Anticancer Drugs ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Factors Associated

scholarly journals c-erbB-2 promoter-specific DNA-binding protein isolated from human breast cancer tissues displays mitogenic activity.

1994 ◽  
Vol 269 (16) ◽  
pp. 12285-12289
Author(s):  
F.H. Sarkar ◽  
M.R. Smith ◽  
T. Hoover ◽  
G. Princler ◽  
J.D. Crissman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Binding ◽  
Human Breast Cancer ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Mitogenic Activity ◽  
Human Breast ◽  
Cancer Tissues

Transcription factors link mouse WAP-T mammary tumors with human breast cancer

2012 ◽  
Vol 132 (6) ◽  
pp. 1311-1322 ◽  
Author(s):  
Benjamin Otto ◽  
Thomas Streichert ◽  
Florian Wegwitz ◽  
Heidrun Gevensleben ◽  
Kristin Klätschke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factors ◽  
Human Breast Cancer ◽  
Mammary Tumors ◽  
Human Breast

Study the Effect of Anticancer Drugs on Human Breast Cancer Cells Using Three Dimensional Silicon Microstructures

2008 ◽  
Author(s):  
Mehdi Nikkhah ◽  
Jeannine S. Strobl ◽  
Masoud Agah
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Trichostatin A ◽  
Three Dimensional ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Adhesion Properties

In this paper we report development of three dimensional silicon microenvironments in order to test the morphological changes and adhesion properties of human breast cancer cells after treatment with different anticancer drugs such as Trichostatin A (TSA), suberoylanilide hydroxamic acid (SAHA) and Scriptaid. Our results indicate that the cancer cells reorganize their cytoskeleton structure after treatment with TSA and Scriptaid. However, SAHA does not change the behavior of the cells inside the three dimensional microstructures while TSA and Scriptaid evoked striking changes in the cells morphology. TSA and Scriptaid drugs cause the cells to stretch inside the isotropic microchambers to avoid contact with curved sidewalls in contrast to their originally rounded shape. The proposed microstructures can be used to evaluate mechanical properties and the pathological grade of various cancer cell lines after different conditions i.e. drug exposure.

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