scholarly journals Encapsulation of a cationic antimicrobial peptide into self-assembled polyion complex nano-objects enhances its antitumor properties

2022 ◽  
Vol 1249 ◽  
pp. 131482
Author(s):  
Mina Răileanu ◽  
Barbara Lonetti ◽  
Charles-Louis Serpentini ◽  
Dominique Goudounèche ◽  
Laure Gibot ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Cationic Antimicrobial Peptide ◽  
Polyion Complex ◽  
Antitumor Properties ◽  
Self Assembled

The efficacy of self-assembled cationic antimicrobial peptide nanoparticles against Cryptococcus neoformans for the treatment of meningitis

Biomaterials ◽  
2010 ◽  
Vol 31 (10) ◽  
pp. 2874-2881 ◽  
Author(s):  
Huaying Wang ◽  
Kaijin Xu ◽  
Lihong Liu ◽  
Jeremy P.K. Tan ◽  
Yunbo Chen ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Cryptococcus Neoformans ◽  
Cationic Antimicrobial Peptide ◽  
Peptide Nanoparticles ◽  
Self Assembled

Highly efficient nanomedicine from cationic antimicrobial peptide-protected Ag nanoclusters

2021 ◽  
Author(s):  
Zhikai Ye ◽  
Haishuang Zhu ◽  
Shan Zhang ◽  
Jing Li ◽  
Jin Wang ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Biological Systems ◽  
Cationic Antimicrobial Peptide ◽  
Highly Efficient ◽  
Antimicrobial Efficiency ◽  
Ag Nanoclusters ◽  
Fine Tune

Designing the homogeneous assembly of the bio–nano interface to fine-tune the interactions between the nanoprobes and biological systems is of prime importance to improve the antimicrobial efficiency of nanomedicines.

scholarly journals Insights into the Action Mechanism of the Antimicrobial Peptide Lasioglossin III

2021 ◽  
Vol 22 (6) ◽  
pp. 2857
Author(s):  
Filomena Battista ◽  
Rosario Oliva ◽  
Pompea Del Vecchio ◽  
Roland Winter ◽  
Luigi Petraccone
Keyword(s):  
Antimicrobial Peptide ◽  
Gram Negative Bacteria ◽  
Lipid Domains ◽  
Action Mechanism ◽  
Cationic Antimicrobial Peptide ◽  
Intracellular Targeting ◽  
Gel Retardation Assay ◽  
Charged Membrane ◽  
Intracellular Target ◽  
Anionic Lipids

Lasioglossin III (LL-III) is a cationic antimicrobial peptide derived from the venom of the eusocial bee Lasioglossum laticeps. LL-III is extremely toxic to both Gram-positive and Gram-negative bacteria, and it exhibits antifungal as well as antitumor activity. Moreover, it shows low hemolytic activity, and it has almost no toxic effects on eukaryotic cells. However, the molecular basis of the LL-III mechanism of action is still unclear. In this study, we characterized by means of calorimetric (DSC) and spectroscopic (CD, fluorescence) techniques its interaction with liposomes composed of a mixture of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-rac-phosphoglycerol (POPG) lipids as a model of the negatively charged membrane of pathogens. For comparison, the interaction of LL-III with the uncharged POPC liposomes was also studied. Our data showed that LL-III preferentially interacted with anionic lipids in the POPC/POPG liposomes and induces the formation of lipid domains. Furthermore, the leakage experiments showed that the peptide could permeabilize the membrane. Interestingly, our DSC results showed that the peptide-membrane interaction occurs in a non-disruptive manner, indicating an intracellular targeting mode of action for this peptide. Consistent with this hypothesis, our gel-retardation assay experiments showed that LL-III could interact with plasmid DNA, suggesting a possible intracellular target.

Spermicidal efficacy of VRP, a synthetic cationic antimicrobial peptide, inducing apoptosis and membrane disruption

2017 ◽  
Vol 233 (2) ◽  
pp. 1041-1050 ◽  
Author(s):  
Prasanta Ghosh ◽  
Arpita Bhoumik ◽  
Sudipta Saha ◽  
Sandipan Mukherjee ◽  
Sarfuddin Azmi ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Membrane Disruption ◽  
Cationic Antimicrobial Peptide

Chemically Immobilized Antimicrobial Peptide on Polymer and Self-Assembled Monolayer Substrates

Langmuir ◽  
2018 ◽  
Vol 34 (43) ◽  
pp. 12889-12896 ◽  
Author(s):  
Minyu Xiao ◽  
Joshua Jasensky ◽  
Jonathan Gerszberg ◽  
Junjie Chen ◽  
Jiayi Tian ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Self Assembled Monolayer ◽  
Self Assembled

scholarly journals Metallohelices that kill Gram-negative pathogens using intracellular antimicrobial peptide pathways

2019 ◽  
Vol 10 (42) ◽  
pp. 9708-9720 ◽  
Author(s):  
Daniel H. Simpson ◽  
Alexia Hapeshi ◽  
Nicola J. Rogers ◽  
Viktor Brabec ◽  
Guy J. Clarkson ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Small Peptides ◽  
Gram Negative ◽  
Pure Compounds ◽  
Iron Based ◽  
Self Assembled ◽  
Optically Pure

Iron-based self-assembled optically pure compounds mimic the mechanisms of small peptides, according to biophysical, genomic, transcriptomic and other analyses.

Cationic antimicrobial peptide and its poly-N-substituted glycine congener: Antibacterial and antibiofilm potential against A. baumannii

2019 ◽  
Vol 518 (3) ◽  
pp. 472-478 ◽  
Author(s):  
Deepika Sharma ◽  
Monika Choudhary ◽  
Jitendraa Vashistt ◽  
Rahul Shrivastava ◽  
Gopal Singh Bisht
Keyword(s):  
Antimicrobial Peptide ◽  
Cationic Antimicrobial Peptide
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