Impact of genetic polymorphisms in kinetochore and spindle assembly genes on chromosomal aberration frequency in healthy humans

2020 ◽  
Vol 858-860 ◽  
pp. 503253
Author(s):  
Yasmeen Niazi ◽  
Hauke Thomsen ◽  
Bozena Smolkova ◽  
Ludmila Vodickova ◽  
Soňa Vodenkova ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Chromosomal Aberration ◽  
Spindle Assembly ◽  
Aberration Frequency ◽  
Healthy Humans

scholarly journals Genetic variation associated with chromosomal aberration frequency: A genome-wide association study

2018 ◽  
Vol 60 (1) ◽  
pp. 17-28 ◽  
Author(s):  
Yasmeen Niazi ◽  
Hauke Thomsen ◽  
Bozena Smolkova ◽  
Ludmila Vodickova ◽  
Sona Vodenkova ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Association Study ◽  
Chromosomal Aberration ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Aberration Frequency ◽  
Genome Wide ◽  
A Genome

scholarly journals Genetic polymorphisms of the dopamine and serotonin systems modulate the neurophysiological response to feedback and risk taking in healthy humans

2012 ◽  
Vol 12 (4) ◽  
pp. 678-691 ◽  
Author(s):  
I. Heitland ◽  
R. S. Oosting ◽  
J. M. P. Baas ◽  
S. A. A. Massar ◽  
J. L. Kenemans ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Risk Taking ◽  
Healthy Humans

Quantitative characteristics of chromosomal aberration frequency in the residents of the regions with different levels of cancer incidences

2009 ◽  
Vol 45 (2) ◽  
pp. 211-217 ◽  
Author(s):  
V. I. Minina ◽  
V. G. Druzhinin ◽  
A. N. Glushkov ◽  
S. A. Larin ◽  
S. A. Mun ◽  
...  
Keyword(s):  
Chromosomal Aberration ◽  
Aberration Frequency ◽  
Quantitative Characteristics ◽  
Different Levels

scholarly journals Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries

2008 ◽  
Vol 29 (6) ◽  
pp. 1178-1183 ◽  
Author(s):  
S. Bonassi ◽  
H. Norppa ◽  
M. Ceppi ◽  
U. Stromberg ◽  
R. Vermeulen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Chromosomal Aberration ◽  
Aberration Frequency ◽  
Risk Of Cancer

Spindle scaling mechanisms

2020 ◽  
Vol 64 (2) ◽  
pp. 383-396
Author(s):  
Lara K. Krüger ◽  
Phong T. Tran
Keyword(s):  
Cell Size ◽  
Spindle Assembly ◽  
Dependent Manner ◽  
Post Translational Modification ◽  
Size Dependent ◽  
A Cell ◽  
Chromosome Separation ◽  
Spindle Elongation ◽  
Protein Gradients ◽  
Spindle Structure

Abstract The mitotic spindle robustly scales with cell size in a plethora of different organisms. During development and throughout evolution, the spindle adjusts to cell size in metazoans and yeast in order to ensure faithful chromosome separation. Spindle adjustment to cell size occurs by the scaling of spindle length, spindle shape and the velocity of spindle assembly and elongation. Different mechanisms, depending on spindle structure and organism, account for these scaling relationships. The limited availability of critical spindle components, protein gradients, sequestration of spindle components, or post-translational modification and differential expression levels have been implicated in the regulation of spindle length and the spindle assembly/elongation velocity in a cell size-dependent manner. In this review, we will discuss the phenomenon and mechanisms of spindle length, spindle shape and spindle elongation velocity scaling with cell size.

Sign in / Sign up

Export Citation Format

Share Document