pH-responsive drug release and real-time fluorescence detection of porous silica nanoparticles

2017 ◽  
Vol 77 ◽  
pp. 19-26 ◽  
Author(s):  
Xu Zhang ◽  
Yamin Wang ◽  
Yanbao Zhao ◽  
Lei Sun
Keyword(s):  
Drug Release ◽  
Silica Nanoparticles ◽  
Real Time ◽  
Fluorescence Detection ◽  
Porous Silica ◽  
Ph Responsive

scholarly journals Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Nikola Ž. Knežević ◽  
Sanja Milenković ◽  
Danica Jović ◽  
Slavica Lazarevic ◽  
Jasminka Mrdjanović ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Thermogravimetric Analysis ◽  
Drug Release ◽  
Silica Nanoparticles ◽  
Porous Silica ◽  
Targeted Treatment ◽  
Capping Agent ◽  
Ph Responsive ◽  
Tumor Tissues ◽  
Acidic Conditions

Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues.

A pH-responsive prodrug for real-time drug release monitoring and targeted cancer therapy

2014 ◽  
Vol 50 (80) ◽  
pp. 11852-11855 ◽  
Author(s):  
Shi-Ying Li ◽  
Li-Han Liu ◽  
Hui-Zhen Jia ◽  
Wen-Xiu Qiu ◽  
Lei Rong ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Real Time ◽  
Targeted Cancer Therapy ◽  
Ph Responsive

Multifunctional porous silica nanoparticles for dual responsive drug release

2019 ◽  
Vol 93 (2) ◽  
pp. 324-331
Author(s):  
Xindang Bo ◽  
Qianqian Zhang ◽  
Xinli Li ◽  
Yanbao Zhao
Keyword(s):  
Drug Release ◽  
Silica Nanoparticles ◽  
Porous Silica ◽  
Dual Responsive

Real-time imaging of intracellular drug release from mesoporous silica nanoparticles based on fluorescence resonance energy transfer

2014 ◽  
Vol 2 (27) ◽  
pp. 4379-4386 ◽  
Author(s):  
Jun Wang ◽  
Peng Pei Gao ◽  
Xiao Xi Yang ◽  
Ting Ting Wang ◽  
Jian Wang ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Real Time ◽  
Fluorescence Resonance Energy Transfer ◽  
Mesoporous Silica Nanoparticles ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Fluorescence Resonance

A multifunctional nanodevice is designed based on doxorubicin (DOX)-loaded green fluorescent mesoporous silica nanoparticles (FMSN) conjugated with folic acid (FA). Real-time monitoring of intracellular drug release based on fluorescence resonance energy transfer is achieved.

pH-Sensitive nanogates based on poly(l-histidine) for controlled drug release from mesoporous silica nanoparticles

2016 ◽  
Vol 7 (7) ◽  
pp. 1475-1485 ◽  
Author(s):  
Panayiotis Bilalis ◽  
Leto-A. Tziveleka ◽  
Spyridon Varlas ◽  
Hermis Iatrou
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Ph Responsive

Mesoporous silica nanoparticles (MSNs) bearing poly(l-histidine)-grafted nanogates were prepared by surface-initiated ROP. The obtained polypeptide-functionalized MSNs were used as smart pH-responsive nanocarriers for controlled drug release applications.

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