scholarly journals Controlled degradability of PCL-ZnO nanofibrous scaffolds for bone tissue engineering and their antibacterial activity

2018 ◽  
Vol 93 ◽  
pp. 724-738 ◽  
Author(s):  
Betiana Felice ◽  
María Alejandra Sánchez ◽  
María Cecilia Socci ◽  
Luciano David Sappia ◽  
María Inés Gómez ◽  
...  
2019 ◽  
Vol 7 (5) ◽  
pp. 1973-1983 ◽  
Author(s):  
Qianmin Ou ◽  
Yingling Miao ◽  
Fanqiao Yang ◽  
Xuefeng Lin ◽  
Li-Ming Zhang ◽  
...  

In bone tissue engineering, it is important for biomaterials to promote the osteogenic differentiation of stem cells to achieve tissue regeneration.


2009 ◽  
Vol 1235 ◽  
Author(s):  
Junping Wang ◽  
Xiaojun Yu

AbstractIn the previous studies, we have successfully developed a novel spiral structured nanofibrous scaffolds with improved osteoconductivity for bone tissue engineering. The spiral structure design facilitates the nutrient transport and waste removal, and allows uniform cellular growth and distribution within the scaffolds, thus enhanced the bioactivity of the scaffolds. In this chapter, HAP and BMP-2 were incorporated within the nanofibrous spiral scaffolds in order to enhance the osteoinductivity of the established system. The effect of the blending materials was evaluated through cell proliferation, cell differentiation of human osteoblast cells seeded on the scaffolds and cultured for 4 and 8 days. The results has demonstrated that the functionalization of PCL nanofibrous spiral scaffolds leads to higher ALP expression level and increased amount of mineralization level however lower cell proliferation rate.


CrystEngComm ◽  
2021 ◽  
Author(s):  
Qaisar Nawaz ◽  
Araceli de Pablos Martin ◽  
Lutz Berthold ◽  
Juliana Martins de Souza e Silva ◽  
Katrin Hurle ◽  
...  

Bioactive glasses (BGs) incorporating metallic ions to impart antibacterial activity and stimulation of osteogenesis and angiogenesis are promising candidates for bone tissue engineering. Silicate BGs of the 45S5 composition (45...


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