Mapping the elemental and crystalline phase distribution in Cu2+ doped 45S5 bioactive glass upon crystallization

Bioactive glasses (BGs) incorporating metallic ions to impart antibacterial activity and stimulation of osteogenesis and angiogenesis are promising candidates for bone tissue engineering. Silicate BGs of the 45S5 composition (45...

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Phosphorous pentoxide-free bioactive glass exhibits dose-dependent angiogenic and osteogenic capacities which are retained in glass polymeric composite scaffolds

Biomaterials Science ◽

10.1039/d1bm01311d ◽

2021 ◽

Author(s):

Sonia Font Tellado ◽

José A. Delgado ◽

Patrina S.P. Poh ◽

Wen Zhang ◽

Maite García-Vallés ◽

...

Keyword(s):

Tissue Engineering ◽

Bioactive Glass ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Polymeric Composite ◽

Composite Scaffolds ◽

Bioactive Glasses ◽

Phosphorous Pentoxide ◽

Dose Dependent

Bioactive glasses (BGs) are attractive materials for bone tissue engineering because of their bioactivity and osteoinductivity. In this study, we report the synthesis of a novel phosphorous pentoxide-free, silicate-based bioactive...

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Fabrication and Characterization of Cinnamaldehyde-Loaded Mesoporous Bioactive Glass Nanoparticles/PHBV-Based Microspheres for Preventing Bacterial Infection and Promoting Bone Tissue Regeneration

Polymers ◽

10.3390/polym13111794 ◽

2021 ◽

Vol 13 (11) ◽

pp. 1794

Author(s):

Kittipat Chotchindakun ◽

Jeeraporn Pekkoh ◽

Jetsada Ruangsuriya ◽

Kai Zheng ◽

Irem Unalan ◽

...

Keyword(s):

Tissue Engineering ◽

Antibacterial Activity ◽

Bioactive Glass ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Average Particle Size ◽

Average Particle ◽

Osteosarcoma Cell ◽

Composite Microspheres ◽

Mesoporous Bioactive Glass

Polyhydroxybutyrate-co-hydroxyvalerate (PHBV) is considered a suitable polymer for drug delivery systems and bone tissue engineering due to its biocompatibility and biodegradability. However, the lack of bioactivity and antibacterial activity hinders its biomedical applications. In this study, mesoporous bioactive glass nanoparticles (MBGN) were incorporated into PHBV to enhance its bioactivity, while cinnamaldehyde (CIN) was loaded in MBGN to introduce antimicrobial activity. The blank (PHBV/MBGN) and the CIN-loaded microspheres (PHBV/MBGN/CIN5, PHBV/MBGN/CIN10, and PHBV/MBGN/CIN20) were fabricated by emulsion solvent extraction/evaporation method. The average particle size and zeta potential of all samples were investigated, as well as the morphology of all samples evaluated by scanning electron microscopy. PHBV/MBGN/CIN5, PHBV/MBGN/CIN10, and PHBV/MBGN/CIN20 significantly exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli in the first 3 h, while CIN releasing behavior was observed up to 7 d. Human osteosarcoma cell (MG-63) proliferation and attachment were noticed after 24 h cell culture, demonstrating no adverse effects due to the presence of microspheres. Additionally, the rapid formation of hydroxyapatite on the composite microspheres after immersion in simulated body fluid (SBF) during 7 d revealed the bioactivity of the composite microspheres. Our findings indicate that this system represents an alternative model for an antibacterial biomaterial for potential applications in bone tissue engineering.

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Effects of Boron Oxide Concentration and Carbon Nanotubes Reinforcement on Bioactive Glass Scaffolds for Bone Tissue Engineering

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2021.19370 ◽

2021 ◽

Vol 21 (10) ◽

pp. 5026-5035

Author(s):

Kartikeya Dixit ◽

Niraj Sinha

Keyword(s):

Carbon Nanotubes ◽

Tissue Engineering ◽

Compressive Strength ◽

Bioactive Glass ◽

Bone Tissue Engineering ◽

Trabecular Bone ◽

Bone Tissue ◽

Polymer Foam ◽

Bioactive Glasses ◽

X Ray

In this work, the effect of varying content of B2O3 with respect to SiO2 on mechanical and bioactivity properties have been evaluated for borosilicate bioactive glasses containing SiO2, B2O3, CaO and P2O5. The bioactive glasses have been synthesized using the sol–gel technique. The synthesized glasses were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and Field Emission Scanning electron microscopy (FESEM). These bioactive glasses were fabricated as scaffolds by using polymer foam replication method. Subsequently, in vitro bioactivity evaluation of borosilicate bioactive glass was done. Based on the XRD and energy-dispersive X-ray spectroscopy (EDS) results showing good apatite-formation ability when soaked in simulated body fluid (SBF), one of the bioactive glass (BG-B30 containing 30 mol% B2O3) was selected for further study. The compressive strength of the bioactive glass scaffolds was within the range of trabecular bone. However, it was found near the lower limit of the trabecular bone (0.2–12 MPa). Therefore, BG-B30 scaffold was reinforced with carbon nanotubes (CNTs) to allow for mechanical manipulation during tissue engineering applications. The compressive strength increased from 1.05 MPa to 7.42 MPa (a 606% increase) after reinforcement, while the fracture toughness rose from 0.12 MPa √ m to 0.45 MPa √ m (a 275% increase). Additionally, connectivity of the pores in the CNT reinforced BG-B30 scaffolds were evaluated and the pores were found to be well connected. The evaluated properties of the fabricated scaffolds demonstrate their potential as a synthetic graft for possible application in bone tissue engineering.

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