Chitosan-covered calcium phosphate particles as a drug vehicle for delivery to the eye

2021 ◽  
pp. 102493
Author(s):  
Ekaterina V. Popova ◽  
Victoria E. Tikhomirova ◽  
Olga V. Beznos ◽  
Natalia B. Chesnokova ◽  
Yuri V. Grigoriev ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphate Particles ◽  
Drug Vehicle

scholarly journals The study of the microstructure of cheese before and after vacuum drying

2020 ◽  
Vol 10 (4) ◽  
pp. 6007-6014
Keyword(s):  
Calcium Phosphate ◽  
Surface Shape ◽  
Vacuum Drying ◽  
Protein Matrix ◽  
Fat Globules ◽  
Before And After ◽  
Calcium Phosphate Particles ◽  
Structure State ◽  
Cheese Microstructure ◽  
Scanning Electron

Scanning electron microscope allowed us to get screens of different cheese microstructure that form a base for further investigation of a cheese structure state before and after the process of drying and for their comparison. Any cheese structure presents a matrix of proteins penetrated with moisture capillaries; fat globules are located both inside the protein matrix and on a cheese surface. Shape of capillaries is either round or oval. Capillaries vary in size and number that has an impact on the cheese pattern which is described by hole and void shapes and order. Electron microscopy was also used for detecting deposition of calcium phosphate. Particles of calcium phosphate changed in size, before drying they were 10–12 µm, and after drying they reached 20–30 µ. These particles concentrate in the dried cheese and agglomerate into larger particles. The most concentrated calcium phosphate proportion was found in pores and micro-voids of the dry cheese. As for mature cheese samples, calcium lactate was established as well.

scholarly journals Sedimentation Study of Biphasic Calcium Phosphate Particles

2007 ◽  
pp. 365-368
Author(s):  
Ahmed Fatimi ◽  
Jean Francois Tassin ◽  
Monique Aselo V. Axelos ◽  
Pierre Weiss
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Calcium Phosphate Particles

Microfiltration performance: physicochemical aspects of whey pretreatment

1995 ◽  
Vol 62 (2) ◽  
pp. 269-279 ◽  
Author(s):  
Genevieve Gesan ◽  
Georges Daufin ◽  
Uzi Merin ◽  
Jean-Pierre Labbe ◽  
Auguste Quemerais
Keyword(s):  
Calcium Phosphate ◽  
Membrane Surface ◽  
Physicochemical Process ◽  
High Shear ◽  
Lower Content ◽  
Phosphate Ions ◽  
Complex Lipid ◽  
Ionic Calcium ◽  
Calcium Phosphate Particles ◽  
Soluble Calcium

SUMMARYClarification of whey by microfiltration (MF) can be achieved after appropriate pretreatment of the feed. A control pretreatment consists of a physicochemical process comprising increased ionic calcium and pH accompanied by heat (50 °C, 15 min) to cause aggregation of complex lipid–calcium phosphate particles, which are then separated by MF. This pretreatment process was modified by increasing the temperature to 55 °C and by maintaining the pH constant during heat treatment. This modification resulted in larger calcium phosphate particles and a lower content of soluble calcium and phosphate ions. As a consequence, a longer period of MF operation, better whey clarification and lower calcium and phosphate content of the filtrate were achieved. This suggests that a loosely structured deposit was formed on the membrane surface which was less resistant to filtration than that resulting from the control pretreatment. During MF, it was necessary to avoid zones of high shear in the retentate compartment that might cause physical alteration of the aggregates.

Adsorption of milk proteins on to calcium phosphate particles

2013 ◽  
Vol 394 ◽  
pp. 458-466 ◽  
Author(s):  
Lucile Tercinier ◽  
Aiqian Ye ◽  
Skelte Anema ◽  
Anne Singh ◽  
Harjinder Singh
Keyword(s):  
Calcium Phosphate ◽  
Milk Proteins ◽  
Calcium Phosphate Particles

Calcium Phosphate Particles as Pulmonary Delivery System for Interferon-α in Mice

2017 ◽  
Vol 19 (1) ◽  
pp. 395-412 ◽  
Author(s):  
Tülin Morçöl ◽  
Jessica M. Weidner ◽  
Anand Mehta ◽  
Stephen J.D. Bell ◽  
Timothy Block
Keyword(s):  
Calcium Phosphate ◽  
Delivery System ◽  
Pulmonary Delivery ◽  
Interferon Α ◽  
Calcium Phosphate Particles

Quantification of volume and size distribution of internalised calcium phosphate particles and their influence on cell fate

2014 ◽  
Vol 2 (12) ◽  
pp. 1723-1726 ◽  
Author(s):  
Richard L. Williams ◽  
Isaac Vizcaíno-Castón ◽  
Liam M. Grover
Keyword(s):  
Cell Death ◽  
Calcium Phosphate ◽  
Size Distribution ◽  
Cell Fate ◽  
Calcium Phosphate Particles

We report preliminary findings suggesting that the diameter of internalised calcium phosphate particles/aggregates is critical to cell fate, with diameters larger than 1.5 μm leading to cell death.

Adjuvant Effects of Chitosan and Calcium Phosphate Particles in an Inactivated Newcastle Disease Vaccine

2014 ◽  
Vol 58 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Marina A. Volkova ◽  
Anna V. Irza ◽  
Irina A. Chvala ◽  
Sergy F. Frolov ◽  
Vladimir V. Drygin ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Newcastle Disease ◽  
Calcium Phosphate Particles ◽  
Adjuvant Effects ◽  
Newcastle Disease Vaccine

Synthetic Calcium Phosphate Nanoparticles Mimetic of Bone Mineral: Similarities in Composition and Morphology

2006 ◽  
Vol 309-311 ◽  
pp. 507-510 ◽  
Author(s):  
S. Bertazzo ◽  
Celso A. Bertran ◽  
E.Y. Kawachi
Keyword(s):  
Calcium Phosphate ◽  
Bone Mineral ◽  
Calcium Phosphates ◽  
Parietal Bone ◽  
The Body ◽  
Mineral Phase ◽  
Structure Morphology ◽  
Calcium Phosphate Particles ◽  
Calcium Phosphate Nanoparticles ◽  
Synthetic Calcium Phosphate

In this work, calcium phosphate particles were obtained from systems composed of Renex-100, hexanol, cyclohexane and Ca2+, PO4 3- and OH- aqueous solutions. Particles of chemical composition, crystalline structure, morphology and size similar to those of bone mineral were obtained by varying the composition of the components of the system. For comparison, the mineral phase of bone was obtained from parietal bone and femur of 15-day, 1-month and 1-year-old Wistar rats. Synthetic calcium phosphates and bone samples were analyzed by XRD, ICP/OES and electronic microscopy. The results show that, by controlling the composition of the surfactant system, it is possible to obtain particles of different morphologies and sizes, which are more similar to the particles that compose bone mineral. This similarity might indicate that the body makes use of systems to synthesize bone mineral. These systems might present properties similar to those of the systems studied in this work.

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