Inulin Coated Mn3O4 Nanocuboids Coupled with RNA Interference Reverse Intestinal Tumorigenesis in Apc Knockout Murine Colon Cancer Models

Cancer immunotherapy has revolutionized the way different neoplasms are treated. Among the different variations of cancer immunotherapy, the checkpoint inhibitors targeting the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) axis have been validated and are currently used in the clinics. Nevertheless, these therapeutic antibodies are associated with significant side effects and are known to induce immune-related toxicities. To address these issues, we have developed an immune-microbubble complex (IMC) which not only reduces the toxicities associated with the antibodies but also enhances the therapeutic efficacy when combined with focused ultrasound. The concept of IMCs could be applied to any type of antibody-based treatment regimens to maximize their therapeutic potential.

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Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal tumorigenesis in ApcMin/+ mice

Gut ◽

10.1136/gut.2004.060533 ◽

2005 ◽

Vol 54 (8) ◽

pp. 1136-1145 ◽

Cited By ~ 68

Author(s):

T Aparicio

Keyword(s):

Colon Cancer ◽

Cancer Cells ◽

Nude Mice ◽

Human Colon ◽

Colon Cancer Cells ◽

Human Colon Cancer ◽

Intestinal Tumorigenesis ◽

Human Colon Cancer Cells

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Non-viral immune electrogene therapy induces potent antitumour responses and has a curative effect in murine colon adenocarcinoma and melanoma cancer models

Gene Therapy ◽

10.1038/gt.2014.95 ◽

2014 ◽

Vol 22 (1) ◽

pp. 29-39 ◽

Cited By ~ 3

Author(s):

P F Forde ◽

L J Hall ◽

M de Kruijf ◽

M G Bourke ◽

T Doddy ◽

...

Keyword(s):

Colon Adenocarcinoma ◽

Curative Effect ◽

Melanoma Cancer ◽

Cancer Models ◽

Murine Colon

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Synergistic antitumor effects of liposomal honokiol combined with cisplatin in colon cancer models

Oncology Letters ◽

10.3892/ol.2011.350 ◽

2011 ◽

Cited By ~ 2

Author(s):

Tian Xia

Keyword(s):

Colon Cancer ◽

Antitumor Effects ◽

Cancer Models

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Schedule-dependent synergistic effects of 5-fluorouracil and selumetinib in KRAS or BRAF mutant colon cancer models

Biochemical Pharmacology ◽

10.1016/j.bcp.2018.12.017 ◽

2019 ◽

Vol 160 ◽

pp. 110-120 ◽

Cited By ~ 6

Author(s):

Hye Yeon Jang ◽

Do Hyung Kim ◽

Haeng Jung Lee ◽

Won Dong Kim ◽

Seog-Young Kim ◽

...

Keyword(s):

Colon Cancer ◽

Synergistic Effects ◽

Cancer Models ◽

Braf Mutant

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{Ru(CO)x}-Core complexes with benzimidazole ligands: synthesis, X-ray structure and evaluation of anticancer activity in vivo

Dalton Transactions ◽

10.1039/c6dt04295c ◽

2017 ◽

Vol 46 (9) ◽

pp. 3025-3040 ◽

Cited By ~ 17

Author(s):

Gabriella Tamasi ◽

Antonello Merlino ◽

Federica Scaletti ◽

Petra Heffeter ◽

Anton A. Legin ◽

...

Keyword(s):

Colon Cancer ◽

Anticancer Activity ◽

Antitumor Effects ◽

X Ray ◽

Murine Colon

fac-[RuII(CO)3Cl2(MBI)] and -[RuII(CO)3Cl2(DMBI)] are CO-releasing materials able to link histidines of proteins, and the latter showed antitumor effects in murine colon cancer.

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Combinatorial therapy using RNAi and curcumin nano-architectures regresses tumors in breast and colon cancer models

Nanoscale ◽

10.1039/d1nr04411g ◽

2022 ◽

Author(s):

Aviral Kumar ◽

Amarnath Singam ◽

Guruprasadh Swaminathan ◽

Naresh Killi ◽

Naveen Kumar Tangudu ◽

...

Keyword(s):

Colon Cancer ◽

Colorectal Cancers ◽

Murine Models ◽

Combinatorial Therapy ◽

Cancer Models ◽

S 100 ◽

Eudragit S 100

This novel combination of curcumin (CU)–chitosan (CS) nanocomposites conjugated to Ephb4 shRNA encapsulated with Eudragit S-100 (ES) has been developed to combat breast and colorectal cancers murine models.

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