Group I metabotropic glutamate receptors activate the p70S6 kinase via both mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK 1/2) signaling pathways in rat striatal and hippocampal synaptoneurosomes

2006 ◽  
Vol 49 (4) ◽  
pp. 413-421 ◽  
Author(s):  
Guylène Page ◽  
Fuad A.L. Khidir ◽  
Stéphanie Pain ◽  
Laurence Barrier ◽  
Bernard Fauconneau ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
P70s6 Kinase ◽  
Extracellular Signal Regulated Kinase ◽  
Metabotropic Glutamate ◽  
Group I ◽  
Extracellular Signal

Activation of the extracellular signal-regulated kinase 2 by metabotropic glutamate receptors

1999 ◽  
Vol 11 (6) ◽  
pp. 2073-2082 ◽  
Author(s):  
Francesco Ferraguti ◽  
Barbara Baldani-Guerra ◽  
Mauro Corsi ◽  
Shigetada Nakanishi ◽  
Corrado Corti
Keyword(s):  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Extracellular Signal Regulated Kinase ◽  
Metabotropic Glutamate ◽  
Extracellular Signal

Group I Metabotropic Glutamate Receptors Are Differentially Expressed by Two Populations of Olfactory Bulb Granule Cells

2007 ◽  
Vol 97 (4) ◽  
pp. 3136-3141 ◽  
Author(s):  
Thomas Heinbockel ◽  
Kathryn A. Hamilton ◽  
Matthew Ennis
Keyword(s):  
Olfactory Bulb ◽  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Granule Cells ◽  
Mitral Cell ◽  
Mitral Cells ◽  
Patch Clamp Recording ◽  
Metabotropic Glutamate ◽  
Group I ◽  
Bath Application

In the main olfactory bulb, several populations of granule cells (GCs) can be distinguished based on the soma location either superficially, interspersed with mitral cells within the mitral cell layer (MCL), or deeper, within the GC layer (GCL). Little is known about the physiological properties of superficial GCs (sGCs) versus deep GCs (dGCs). Here, we used patch-clamp recording methods to explore the role of Group I metabotropic glutamate receptors (mGluRs) in regulating the activity of GCs in slices from wildtype and mGluR−/− mutant mice. In wildtype mice, bath application of the selective Group I mGluR agonist DHPG depolarized and increased the firing rate of both GC subtypes. In the presence of blockers of fast synaptic transmission (APV, CNQX, gabazine), DHPG directly depolarized both GC subtypes, although the two GC subtypes responded differentially to DHPG in mGluR1−/− and mGluR5−/− mice. DHPG depolarized sGCs in slices from mGluR5−/− mice, although it had no effect on sGCs in slices from mGluR1−/− mice. By contrast, DHPG depolarized dGCs in slices from mGluR1−/− mice but had no effect on dGCs in slices from mGluR5−/− mice. Previous studies showed that mitral cells express mGluR1 but not mGluR5. The present results therefore suggest that sGCs are more similar to mitral cells than dGCs in terms of mGluR expression.

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