Regulation of monoamine levels by typical and atypical antipsychotics in Caenorhabditis elegans mutant for Nuclear Distribution Element genes

2021 ◽  
pp. 105047
Author(s):  
Joana D’Arc Campeiro ◽  
João V. Nani ◽  
Gabriela G. Monte ◽  
PriscilaG.C. Almeida ◽  
Marcelo A. Mori ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Atypical Antipsychotics ◽  
Nuclear Distribution ◽  
Typical And Atypical Antipsychotics

scholarly journals Antipsychotics in dementia: are they being appropriately prescribed?

2010 ◽  
Vol 22 (3) ◽  
pp. 501-502 ◽  
Author(s):  
Fozia Roked ◽  
Asha Omar ◽  
Fayaz Roked ◽  
Ridwan Ahmed ◽  
Abdul Patel
Keyword(s):  
Adverse Effects ◽  
Atypical Antipsychotics ◽  
The Elderly ◽  
Qt Prolongation ◽  
Patient Organizations ◽  
People With Dementia ◽  
Cerebrovascular Events ◽  
Increased Risk ◽  
Excessive Sedation ◽  
Typical And Atypical Antipsychotics

In 2007, the U.K.'s All-Party Parliamentary Group on Dementia (APPG) undertook an inquiry into the prescription of antipsychotics for people with dementia on account of concerns expressed by carers, patient organizations and academics about the appropriateness and safety of these drugs (All-Party Parliamentary Group on Dementia, 2008). It has been estimated that 32% of patients with dementia in care homes are prescribed antipsychotics (Alldred et al., 2007). Both typical and atypical antipsychotics are associated with QT prolongation, which can lead to arrhythmias and sudden death (Joint Formulary Committee, 2009). They are also associated with an increased risk of cerebrovascular events. Adverse effects in the elderly include excessive sedation and dizziness, which can lead to falls and therefore accelerated cognitive decline.

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