scholarly journals The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain

2020 ◽  
Vol 89 ◽  
pp. 1-11 ◽  
Author(s):  
Magali Millecamps ◽  
Xiang Qun Shi ◽  
Marjo Piltonen ◽  
Stefania Echeverry ◽  
Luda Diatchenko ◽  
...  
2016 ◽  
Vol 116 (3) ◽  
pp. 1387-1395 ◽  
Author(s):  
Raghavan Gopalakrishnan ◽  
Richard C. Burgess ◽  
Scott F. Lempka ◽  
John T. Gale ◽  
Darlene P. Floden ◽  
...  

Central poststroke pain (CPSP) is characterized by hemianesthesia associated with unrelenting chronic pain. The final pain experience stems from interactions between sensory, affective, and cognitive components of chronic pain. Hence, managing CPSP will require integrated approaches aimed not only at the sensory but also the affective-cognitive spheres. A better understanding of the brain's processing of pain anticipation is critical for the development of novel therapeutic approaches that target affective-cognitive networks and alleviate pain-related disability. We used magnetoencephalography (MEG) to characterize the neural substrates of pain anticipation in patients suffering from intractable CPSP. Simple visual cues evoked anticipation while patients awaited impending painful (PS), nonpainful (NPS), or no stimulus (NOS) to their nonaffected and affected extremities. MEG responses were studied at gradiometer level using event-related fields analysis and time-frequency oscillatory analysis upon source localization. On the nonaffected side, significantly greater responses were recorded during PS. PS (vs. NPS and NOS) exhibited significant parietal and frontal cortical activations in the beta and gamma bands, respectively, whereas NPS (vs. NOS) displayed greater activation in the orbitofrontal cortex. On the affected extremity, PS (vs. NPS) did not show significantly greater responses. These data suggest that anticipatory phenomena can modulate neural activity when painful stimuli are applied to the nonaffected extremity but not the affected extremity in CPSP patients. This dichotomy may stem from the chronic effects of pain on neural networks leading to habituation or saturation. Future clinically effective therapies will likely be associated with partial normalization of the neurophysiological correlates of pain anticipation.


CAND Journal ◽  
2021 ◽  
Vol 28 (4) ◽  
pp. 11-13
Author(s):  
Shakila Mohmand ◽  
Sumar Chams

Cultural competency within health care helps eliminate racial and ethnic health disparities. When assessing and treating patients with chronic pain, practitioners should feel confident in using information regarding a patient’s individual cultural beliefs due to their significant impact on the pain experience. Culture impacts perception, outlook, and communication of pain, as well as coping mechanisms. These are aspects of subjective history that influence important decisions regarding the management of chronic pain. Becoming more aware of what to look for and which questions to ask can allow naturopathic doctors and other health-care providers to continue improving therapeutic relationships and patient outcomes.


Author(s):  
Lynn R. Webster

“The God Prescription” profiles Walt Alexander, a devout Christian who developed severe chronic pain after suffering accidental nerve damage during surgery. Walt’s faith in God and his support system within his family and his faith community helped him endure his pain and look for the good that could come out of it. Conversely, his pain experience also deepened his submission to God’s will and enhanced his compassion for other people who are in need. Walt’s experience illustrates a truth that scientific research has established: belief tends to affect a person’s pain experience in a positive way. Chapter key idea: Believing in something or Someone bigger than yourself invites healing into your life.


Pain ◽  
2008 ◽  
Vol 135 (3) ◽  
pp. 251-261 ◽  
Author(s):  
Christiane Hermann ◽  
Johanna Hohmeister ◽  
Katrin Zohsel ◽  
Marie-Luise Tuttas ◽  
Herta Flor

1997 ◽  
Vol 2 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Lucy Gagliese ◽  
Ronald Melzack

OBJECTIVE: To assess, in two studies, whether there are any age differences in beliefs about the role of psychological, organic and ageing factors in the experience of chronic pain.SUBJECTS: Healthy adults free from chronic pain ranging in age from 18 to 86 years (first study); adults with chronic pain due to arthritis, fibromyalgia or other rheumatological disorders ranging in age from 27 to 79 years (second study).MATERIALS: In both studies, subjects completed the Pain Beliefs Questionnaire which was modified to measure beliefs about the relationship between pain and ageing. In addition, subjects completed various self-assessments of health, pain intensity and depression. Those with chronic pain also completed the Arthritis Self-Efficacy Scale.RESULTS: There was no evidence of any age differences in beliefs about pain in either the pain-free or chronic pain samples. There was some evidence that elderly patients may report less pain, but there were no age differences found on measures of depression or self-efficacy.CONCLUSIONS: The elderly were no more likely than younger persons to associate pain with the normal ageing process than with organic factors such as tissue damage, nor were they more likely to deny the importance of psychological factors to the pain experience.


2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Robert Jank ◽  
Alexander Gallee ◽  
Markus Boeckle ◽  
Sabine Fiegl ◽  
Christoph Pieh

Background. Chronic pain (CP) and sleep disorders (SD) are highly prevalent in the general population. However, comprehensive data regarding the prevalence and characteristics of pain and SD in primary care are rare. Methods. From N=578 patients N=570 were included within 8 weeks (mean age: 50.8±18.7 years, females: 289). Sociodemographic data, Insomnia Severity Index (ISI), and parts of a self-report questionnaire for pain (Multidimensional German Pain Questionnaire) were recorded and additional medical information (pain medication, sleep medication) was gathered from the patient charts. Results. Of the total sample, 33.2% (n=189) suffer from CP (pain ≥ 6 months) and 29.1% (n=166) from SD. 45.5% of the CP patients suffer from SD and 26.5% from clinical insomnia (ISI ≥ 15). SD (β = 0.872, SE = 0.191,  t = 4,572, p<0.001, CI [0.497; 1.246]) and older age (β = 0.025, SE = 0.005, t = 5.135, p<0.001, CI [0.015; 0.035]) were significantly associated with pain experience. Conclusion. About a quarter of CP patients suffer from clinical insomnia. The suggested bidirectional relation should be considered during comprehensive assessment and treatment of patients.


2011 ◽  
Vol 26 (S2) ◽  
pp. 1006-1006 ◽  
Author(s):  
M. Tsatali ◽  
M. Gouva

IntroductionPain is a complex and multifacial phenomenon, which interferes in almost every person's life, while in case it turns into chronic, can cause a significant disturbance in individual's physical, psychological and social sphere. That means the intense communication and interaction between ache biome, living conditions and state of health. Cognitive factors play a significant role on the recurrent dysphoria levels, while cognitive functions participate actively in pain intensity, sense of disability and medicine response.AimEstimate the possible significance between pain anxiety and pain intensity.Materials and methodsEighty six elders suffering from various types of chronic pain were examined by the Pass-20 (Pain Anxiety Symptoms Scale) scale, and GPM (Geriatric Pain Measure), while the results were assessed by SPSS 14 and specifically the Linear Regression method.ResultsIt was found statistical significance between the four sub-scales and the presence and existence of chronic pain among participants. Specifically the first subcale (avoidance of pain) was linked with the intensity of pain (p = ,00), the second scale (fearfull thinking) was associated with the prevalence of pain and the gender (p = ,014), the third scale (cognitive anxiety) showed a statistic significance with GPM results and education levels (p = ,00) and the forth scale (psychological responses) was found to affect the pain sense, while it was depended by gender (p = ,0015).DiscussionAmong elders pain anxiety can deteriorate the pain sense affecting the general well-being. For that reason non-pharmacological interventions can be very helpful both for the patient and clinician.


Physiology ◽  
2008 ◽  
Vol 23 (6) ◽  
pp. 371-380 ◽  
Author(s):  
Ulrike Bingel ◽  
Irene Tracey

Pain is a highly complex and subjective experience that is not linearly related to the nociceptive input. What is clear from anecdotal reports over the centuries and more recently from animal and human experimentation is that nociceptive information processing and consequent pain perception is subject to significant pro- and anti-nociceptive modulations. These modulations can be initiated reflexively or by contextual manipulations of the pain experience including cognitive and emotional factors. This provides a necessary survival function since it allows the pain experience to be altered according to the situation rather than having pain always dominate. The so-called descending pain modulatory network involving predominantly medial and frontal cortical areas, in combination with specific subcortical and brain stem nuclei appears to be one key system for the endogenous modulation of pain. Furthermore, recent findings from functional and anatomical neuroimaging support the notion that an altered interaction of pro- and anti-nociceptive mechanisms may contribute to the development or maintenance of chronic pain states. Research on the involved circuitry and implemented mechanisms is a major focus of contemporary neuroscientific research in the field of pain and should provide new insights to prevent and treat chronic pain states.


1992 ◽  
Vol 36 (4) ◽  
pp. 252
Author(s):  
J. A. HAYTHORNTHWAITE ◽  
W. J. SIEBER ◽  
R. D. KERNS
Keyword(s):  

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